Anti-GBM crescentic glomerulonephritis with intensive multinucleated giant cells : a case report

Anti-glomerular basement membrane (anti-GBM) disease is a rare but potentially lethal autoimmune disorder with progressive renal dysfunction in a short time span, which is accompanied with or without pulmonary hemorrhage. Serologic test shows positive anti-GBM antibodies, and extensive crescent formation in the renal biopsy, usually without multinucleated giant cells. Our study presents a case of anti-GBM disease with intensive multinucleated giant cells. We reviewed the literature of relative studies on anti-GBM disease.

[1]  M. de Vincentiis,et al.  Goodpasture's syndrome: a clinical update. , 2015, Autoimmunity reviews.

[2]  J. Carrero,et al.  Predictors of renal and patient outcomes in anti-GBM disease : clinicopathologic analysis of a two-centre cohort , 2015 .

[3]  Zhi-Hong Liu,et al.  Comparison of double filtration plasmapheresis with immunoadsorption therapy in patients with anti-glomerular basement membrane nephritis , 2014, BMC Nephrology.

[4]  M. Säemann,et al.  Long-Term Outcome of Anti-Glomerular Basement Membrane Antibody Disease Treated with Immunoadsorption , 2014, PloS one.

[5]  M. Magrey,et al.  Anti-glomerular basement membrane antibody disease treated with rituximab: A case-based review. , 2013, Seminars in arthritis and rheumatism.

[6]  David W. Johnson,et al.  Anti-glomerular basement membrane antibody disease is an uncommon cause of end-stage renal disease. , 2013, Kidney international.

[7]  Ming-hui Zhao,et al.  Association of epitope spreading of antiglomerular basement membrane antibodies and kidney injury. , 2013, Clinical journal of the American Society of Nephrology : CJASN.

[8]  Ming-hui Zhao,et al.  Complement Activation Contributes to the Injury and Outcome of Kidney in Human Anti-glomerular Basement Membrane Disease , 2012, Journal of Clinical Immunology.

[9]  N. Sverzellati,et al.  An integrated approach in the diagnosis of smoking-related interstitial lung diseases , 2012, European Respiratory Review.

[10]  J. Martín-Navarro,et al.  Reversible posterior leukoencephalopathy syndrome in Goodpasture syndrome. , 2012, Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia.

[11]  Ming-hui Zhao,et al.  Anti-Glomerular Basement Membrane Disease: Outcomes of Different Therapeutic Regimens in a Large Single-Center Chinese Cohort Study , 2011, Medicine.

[12]  Ming-hui Zhao,et al.  Advances in human antiglomerular basement membrane disease , 2011, Nature Reviews Nephrology.

[13]  James M. Anderson,et al.  Macrophage fusion and multinucleated giant cells of inflammation. , 2011, Advances in experimental medicine and biology.

[14]  S. Williamson,et al.  A 25-year experience with pediatric anti-glomerular basement membrane disease , 2010, Pediatric Nephrology.

[15]  S. Self.  Goodpasture's 1919 article on the etiology of influenza-the historical road to what we now call Goodpasture Syndrome. , 2009, The American journal of the medical sciences.

[16]  E. Goodpasture.  Landmark Publication from The American Journal of the Medical Sciences: THE SIGNIFICANCE OF CERTAIN PULMONARY LESIONS IN RELATION TO THE ETIOLOGY OF INFLUENZA , 2009, The American journal of the medical sciences.

[17]  E. Díez-Tejedor,et al.  Cyclophosphamide-induced reversible posterior leukoencephalopathy syndrome , 2009, BMJ Case Reports.

[18]  S. Inokuma,et al.  Intrapulmonary hemorrhage in collagen-vascular diseases includes a spectrum of underlying conditions. , 2009, Internal medicine.

[19]  K. Yamagata,et al.  Anti-glomerular basement membrane antibody disease in Japan: part of the nationwide rapidly progressive glomerulonephritis survey in Japan , 2008, Clinical and Experimental Nephrology.

[20]  R. Falk,et al.  Anti-neutrophil cytoplasmic (ANCA) and anti-glomerular basement membrane (GBM) autoantibodies in necrotizing and crescentic glomerulonephritis , 2007, Seminars in Immunopathology.

[21]  Min Chen,et al.  Characteristics and Outcome of Chinese Patients with Both Antineutrophil Cytoplasmic Antibody and Antiglomerular Basement Membrane Antibodies , 2007, Nephron Clinical Practice.

[22]  Ming-hui Zhao,et al.  Natural anti-GBM antibodies from normal human sera recognize alpha3(IV)NC1 restrictively and recognize the same epitopes as anti-GBM antibodies from patients with anti-GBM disease. , 2007, Clinical immunology.

[23]  Z. Cui,et al.  Natural autoantibodies against glomerular basement membrane exist in normal human sera. , 2006, Kidney international.

[24]  P. van Paassen,et al.  Coexistence of anti-glomerular basement membrane antibodies and myeloperoxidase-ANCAs in crescentic glomerulonephritis. , 2005, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[25]  T. Dougan,et al.  Clinical features and outcome of patients with both ANCA and anti-GBM antibodies. , 2004, Kidney international.

[26]  M. Lam,et al.  Incidence and outcome of antiglomerular basement membrane disease in Chinese , 2004, Nephrology.

[27]  J. Wieslander,et al.  The Prognostic Significance in Goodpasture’s Disease of Specificity, Titre and Affinity of Anti-Glomerular-Basement-Membrane Antibodies , 2003, Nephron Clinical Practice.

[28]  B. Hudson,et al.  The Goodpasture Autoantigen , 2000, The Journal of Biological Chemistry.

[29]  A. Rees,et al.  Anti-Glomerular Basement Membrane Disease , 2020, Definitions.

[30]  J. Hermans,et al.  Renal granulomas in systemic vasculitis. EC/BCR Project for ANCA-Assay Standardization. , 1997, Clinical nephrology.

[31]  J. Wieslander,et al.  Characterization of anti-GBM antibodies involved in Goodpasture's syndrome. , 1994, Kidney international.

[32]  R. Lerner,et al.  THE ROLE OF ANTI-GLOMERULAR BASEMENT MEMBRANE ANTIBODY IN THE PATHOGENESIS OF HUMAN GLOMERULONEPHRITIS , 1967, The Journal of experimental medicine.

[33]  R. J. Porter.  GOODPASTURE'S SYNDROME (PULMONARY HAEMORRHAGE ASSOCIATED WITH GLOMERULONEPHRITIS). , 1964, Proceedings of the Royal Society of Medicine.