Two rotating cilia in the node cavity are sufficient to break left–right symmetry in the mouse embryo

[1]  Y. Saijoh,et al.  Left-right asymmetry in the level of active Nodal protein produced in the node is translated into left-right asymmetry in the lateral plate of mouse embryos. , 2011, Developmental biology.

[2]  M. Blum,et al.  The Nodal Inhibitor Coco Is a Critical Target of Leftward Flow in Xenopus , 2010, Current Biology.

[3]  A. Wynshaw-Boris,et al.  Planar polarization of node cells determines the rotational axis of node cilia , 2010, Nature Cell Biology.

[4]  H. Hamada,et al.  Reversal of left-right asymmetry induced by aberrant Nodal signaling in the node of mouse embryos , 2009, Development.

[5]  M. Blum,et al.  Flow on the right side of the gastrocoel roof plate is dispensable for symmetry breakage in the frog Xenopus laevis. , 2009, Developmental biology.

[6]  C. Tabin,et al.  Cell Movements at Hensen’s Node Establish Left/Right Asymmetric Gene Expression in the Chick , 2009, Science.

[7]  O. Piro,et al.  Embryonic nodal flow and the dynamics of nodal vesicular parcels , 2007, Journal of The Royal Society Interface.

[8]  M. Blum,et al.  Cilia-Driven Leftward Flow Determines Laterality in Xenopus , 2007, Current Biology.

[9]  N. Hirokawa,et al.  Nodal Flow and the Generation of Left-Right Asymmetry , 2006, Cell.

[10]  W. Marshall,et al.  De Novo Formation of Left–Right Asymmetry by Posterior Tilt of Nodal Cilia , 2005, PLoS biology.

[11]  N. Hirokawa,et al.  Mechanism of Nodal Flow: A Conserved Symmetry Breaking Event in Left-Right Axis Determination , 2005, Cell.

[12]  N. Hirokawa,et al.  FGF-induced vesicular release of Sonic hedgehog and retinoic acid in leftward nodal flow is critical for left–right determination , 2005, Nature.

[13]  M. Tokeshi,et al.  High-speed micro-PIV measurements of transient flow in microfluidic devices , 2004 .

[14]  O. Piro,et al.  Fluid-dynamical basis of the embryonic development of left-right asymmetry in vertebrates. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[15]  C. Ucla,et al.  The Transcription Factor RFX3 Directs Nodal Cilium Development and Left-Right Asymmetry Specification , 2004, Molecular and Cellular Biology.

[16]  M. Brueckner,et al.  Two Populations of Node Monocilia Initiate Left-Right Asymmetry in the Mouse , 2003, Cell.

[17]  Jing Zhou,et al.  Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells , 2003, Nature Genetics.

[18]  Y. Saijoh,et al.  Determination of left–right patterning of the mouse embryo by artificial nodal flow , 2002, Nature.

[19]  Hiroshi Suzuki,et al.  Hydrocephalus, Situs Inversus, Chronic Sinusitis, and Male Infertility in DNA Polymerase λ-Deficient Mice: Possible Implication for the Pathogenesis of Immotile Cilia Syndrome , 2002, Molecular and Cellular Biology.

[20]  Hiroshi Hamada,et al.  Establishment of vertebrate left–right asymmetry , 2002, Nature Reviews Genetics.

[21]  N. Hirokawa,et al.  Abnormal nodal flow precedes situs inversus in iv and inv mice. , 1999, Molecular cell.

[22]  N. Hirokawa,et al.  Randomization of Left–Right Asymmetry due to Loss of Nodal Cilia Generating Leftward Flow of Extraembryonic Fluid in Mice Lacking KIF3B Motor Protein , 1999, Cell.

[23]  N. Copeland,et al.  Reversal of left-right asymmetry: a situs inversus mutation. , 1993, Science.

[24]  B. Afzelius.  A human syndrome caused by immotile cilia. , 1976, Science.

[25]  B. Clarke,et al.  Primary cilia mediate mechanosensing in bone cells by a calcium-independent mechanism , 2008 .

[26]  C. Tabin,et al.  A two-cilia model for vertebrate left-right axis specification. , 2003, Genes & development.

[27]  Y. Saijoh,et al.  Two-step regulation of left-right asymmetric expression of Pitx2: initiation by nodal signaling and maintenance by Nkx2. , 2001, Molecular cell.