Inhibition of tumor invasion and metastasis by targeting TGF-β-Smad-MMP2 pathway with Asiatic acid and Naringenin

[1]  V. Costa,et al.  The Multifaceted Role of Annexin A1 in Viral Infections , 2023, Cells.

[2]  H. Lan,et al.  Combination of Asiatic Acid and Naringenin Modulates NK Cell Anti-cancer Immunity by Rebalancing Smad3/Smad7 Signaling. , 2018, Molecular therapy : the journal of the American Society of Gene Therapy.

[3]  S. Adams,et al.  Matrix Metalloproteinase Inhibitors in Cancer Therapy: Turning Past Failures Into Future Successes , 2018, Molecular Cancer Therapeutics.

[4]  F. Verrecchia,et al.  Transforming Growth Factor-β Signaling Plays a Pivotal Role in the Interplay Between Osteosarcoma Cells and Their Microenvironment , 2018, Front. Oncol..

[5]  J. Krstić,et al.  Transforming growth factor‐β, matrix metalloproteinases, and urokinase‐type plasminogen activator interaction in the cancer epithelial to mesenchymal transition , 2018, Developmental dynamics : an official publication of the American Association of Anatomists.

[6]  F. Bazer,et al.  Naringenin‐Induced Apoptotic Cell Death in Prostate Cancer Cells Is Mediated via the PI3K/AKT and MAPK Signaling Pathways , 2017, Journal of cellular biochemistry.

[7]  Xuming Deng,et al.  Asiatic acid enhances Nrf2 signaling to protect HepG2 cells from oxidative damage through Akt and ERK activation. , 2017, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[8]  H. Popper.  Progression and metastasis of lung cancer , 2016, Cancer and Metastasis Reviews.

[9]  J. Yang,et al.  Invading one step at a time: the role of invadopodia in tumor metastasis , 2014, Oncogene.

[10]  P. Dijke,et al.  TGF-β signalling and its role in cancer progression and metastasis , 2012, Cancer and Metastasis Reviews.

[11]  Christian Freudlsperger,et al.  TGF-β and NF-κB signal pathway cross-talk is mediated through TAK1 and SMAD7 in a subset of head and neck cancers , 2012, Oncogene.

[12]  M. Sogayar,et al.  TGF-β1 modulates the homeostasis between MMPs and MMP inhibitors through p38 MAPK and ERK1/2 in highly invasive breast cancer cells , 2012, BMC Cancer.

[13]  P. Dijke,et al.  The TGF-β/Smad pathway induces breast cancer cell invasion through the up-regulation of matrix metalloproteinase 2 and 9 in a spheroid invasion model system , 2011, Breast Cancer Research and Treatment.

[14]  Junliang Yang,et al.  Naringenin attenuates mucous hypersecretion by modulating reactive oxygen species production and inhibiting NF-κB activity via EGFR-PI3K-Akt/ERK MAPKinase signaling in human airway epithelial cells , 2011, Molecular and Cellular Biochemistry.

[15]  E. Bottinger,et al.  Smad2 protects against TGF-beta/Smad3-mediated renal fibrosis. , 2010, Journal of the American Society of Nephrology : JASN.

[16]  Z. Werb,et al.  Matrix Metalloproteinases: Regulators of the Tumor Microenvironment , 2010, Cell.

[17]  J. S. Rao,et al.  MMP‐2 alters VEGF expression via αVβ3 integrin‐mediated PI3K/AKT signaling in A549 lung cancer cells , 2009, International journal of cancer.

[18]  F. Tsai,et al.  Transforming growth factor-beta1 increases cell migration and beta1 integrin up-regulation in human lung cancer cells. , 2009, Lung cancer.

[19]  J. Keski‐Oja,et al.  MT1-MMP releases latent TGF-beta1 from endothelial cell extracellular matrix via proteolytic processing of LTBP-1. , 2008, Experimental cell research.

[20]  J. Massagué,et al.  TGFβ in Cancer , 2008, Cell.

[21]  G. Jenkins.  The role of proteases in transforming growth factor-beta activation. , 2008, The international journal of biochemistry & cell biology.

[22]  D. Edwards,et al.  The regulation of matrix metalloproteinases and their inhibitors. , 2008, The international journal of biochemistry & cell biology.

[23]  A. Mauviel,et al.  Transforming growth factor‐β in cutaneous melanoma , 2008, Pigment cell & melanoma research.

[24]  M. Stack,et al.  Multi-step pericellular proteolysis controls the transition from individual to collective cancer cell invasion , 2007, Nature Cell Biology.

[25]  A. Moon,et al.  TGF-β-induced transcriptional activation of MMP-2 is mediated by activating transcription factor (ATF)2 in human breast epithelial cells , 2007 .

[26]  D. Boyd,et al.  Regulation of matrix metalloproteinase gene expression , 2007, Journal of cellular physiology.

[27]  S. Jakowlew.  Transforming growth factor-β in cancer and metastasis , 2006, Cancer and Metastasis Reviews.

[28]  R. Beauchamp,et al.  Role of Smad proteins in the regulation of NF-κB by TGF-β in colon cancer cells , 2006 .

[29]  K. Verschueren,et al.  Involvement of Ets-1 transcription factor in inducing matrix metalloproteinase-2 expression by epithelial-mesenchymal transition in human squamous carcinoma cells. , 2006, International journal of oncology.

[30]  Fang Liu,et al.  Signaling mechanism of TGF-beta1 in prevention of renal inflammation: role of Smad7. , 2005, Journal of the American Society of Nephrology : JASN.

[31]  S. Kuo,et al.  Expression spectra of matrix metalloproteinases in metastatic non-small cell lung cancer. , 2004, Oncology reports.

[32]  Ivan Ovcharenko,et al.  ECR Browser: a tool for visualizing and accessing data from comparisons of multiple vertebrate genomes , 2004, Nucleic Acids Res..

[33]  G. Taraboletti,et al.  Matrix metalloproteinases (MMP9 and MMP2) induce the release of vascular endothelial growth factor (VEGF) by ovarian carcinoma cells: implications for ascites formation. , 2003, Cancer research.

[34]  M. Bernardo,et al.  Pro-MMP-9 activation by the MT1-MMP/MMP-2 axis and MMP-3: role of TIMP-2 and plasma membranes. , 2003, Biochemical and biophysical research communications.

[35]  D. Nam,et al.  Asiatic acid, a triterpene, induces apoptosis through intracellular Ca2+ release and enhanced expression of p53 in HepG2 human hepatoma cells. , 2002, Cancer letters.

[36]  Carlos López-Otín,et al.  Strategies for MMP inhibition in cancer: innovations for the post-trial era , 2002, Nature Reviews Cancer.

[37]  Lynda F. Bonewald,et al.  Proteolysis of Latent Transforming Growth Factor-β (TGF-β)-binding Protein-1 by Osteoclasts , 2002, The Journal of Biological Chemistry.

[38]  R. Kucherlapati,et al.  Functional Characterization of Transforming Growth Factor β Signaling in Smad2- and Smad3-deficient Fibroblasts* , 2001, The Journal of Biological Chemistry.

[39]  T. Tsushima,et al.  Transforming growth factor‐β1 level correlates with angiogenesis, tumor progression, and prognosis in patients with nonsmall cell lung carcinoma , 2001 .

[40]  J. Becker,et al.  Expression and activation of matrix metalloproteinase‐2 (MMP‐2) and its co‐localization with membrane‐type 1 matrix metalloproteinase (MT1‐MMP) correlate with melanoma progression , 2000 .

[41]  C. Bucana,et al.  Differential expression of E-cadherin and type IV collagenase genes predicts outcome in patients with stage I non-small cell lung carcinoma. , 2000, Clinical cancer research : an official journal of the American Association for Cancer Research.

[42]  I. Stamenkovic,et al.  Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis. , 2000, Genes & development.

[43]  C. Rossi,et al.  Inhibition of gelatinase A (MMP‐2) by batimastat and captopril reduces tumor growth and lung metastases in mice bearing Lewis lung carcinoma , 1999, International journal of cancer.

[44]  W. Stetler-Stevenson,et al.  Matrix metalloproteinases in angiogenesis: a moving target for therapeutic intervention. , 1999, The Journal of clinical investigation.

[45]  G. Giannelli,et al.  Induction of cell migration by matrix metalloprotease-2 cleavage of laminin-5. , 1997, Science.

[46]  R. Fridman,et al.  Activation of progelatinase B (MMP-9) by gelatinase A (MMP-2). , 1995, Cancer research.

[47]  H. Ford,et al.  Molecular Pathways Molecular Pathways : Targeting the TGF-b Pathway for Cancer Therapy , 2012 .

[48]  K. Mohammad,et al.  TGF-beta-RI kinase inhibitor SD-208 reduces the development and progression of melanoma bone metastases. , 2011, Cancer research.

[49]  Jochen Herms,et al.  Real-time imaging reveals the single steps of brain metastasis formation , 2010, Nature Medicine.

[50]  David Padua,et al.  Roles of TGFβ in metastasis , 2009, Cell Research.

[51]  B. Fingleton.  MMP Inhibitor Clinical Trials – The Past, Present, and Future , 2008 .

[52]  A. Mauviel,et al.  Transforming growth factor-b in cutaneous melanoma , 2008 .

[53]  I. Ovcharenko,et al.  ECRbase: database of evolutionary conserved regions, promoters, and transcription factor binding sites in vertebrate genomes , 2007, Bioinform..

[54]  R. Beauchamp,et al.  Role of Smad proteins in the regulation of NF-kappaB by TGF-beta in colon cancer cells. , 2006, Cellular signalling.

[55]  Sarah L Dallas,et al.  Proteolysis of latent transforming growth factor-beta (TGF-beta )-binding protein-1 by osteoclasts. A cellular mechanism for release of TGF-beta from bone matrix. , 2002, The Journal of biological chemistry.

[56]  A. Alavi,et al.  Incidence of Sentinel Node Metastasis in Patients With Thin Primary Melanoma (#1 mm) With Vertical Growth Phase , 2000, Annals of Surgical Oncology.

[57]  W. Stetler-Stevenson,et al.  Matrix metalloproteinases and metastasis , 1999, Cancer Chemotherapy and Pharmacology.