Measurement of kynurenic acid in mammalian brain extracts and cerebrospinal fluid by high-performance liquid chromatography with fluorometric and coulometric electrode array detection.

[1]  D. Potter,et al.  Seizure-like activity and cellular damage in rat hippocampal neurons in cell culture , 1989, Neuron.

[2]  A. Foster,et al.  HA-966 antagonizes N-methyl-D-aspartate receptors through a selective interaction with the glycine modulatory site , 1989, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[3]  R. Schwarcz,et al.  High-affinity uptake of L-kynurenine by a Na+-independent transporter of neutral amino acids in astrocytes , 1989, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[4]  C. Jahr,et al.  Interaction of 6-cyano-7-nitroquinoxaline-2,3-dione with the N-methyl-D-aspartate receptor-associated glycine binding site. , 1989, Molecular pharmacology.

[5]  R. Schwarcz,et al.  Rat Brain Slices Produce and Liberate Kynurenic Acid upon Exposure to l‐Kynurenine , 1989, Journal of neurochemistry.

[6]  G. Lynch,et al.  A Glycine Site Associated with N‐Methyl‐d‐Aspartic Acid Receptors: Characterization and Identification of a New Class of Antagonists , 1989, Journal of neurochemistry.

[7]  L. Vyklický,et al.  Regulation of NMDA receptor desensitization in mouse hippocampal neurons by glycine , 1989, Nature.

[8]  A. Thomson,et al.  Glycine enhances NMDA-receptor mediated synaptic potentials in neocortical slices , 1989, Nature.

[9]  J. Kemp,et al.  Glycine maintains excitement , 1989, Nature.

[10]  F. Moroni,et al.  Increase in Kynurenic Acid in Huntington's Disease Motor Cortex , 1989, Journal of neurochemistry.

[11]  B. Chenard,et al.  Glycine reverses 7-Cl kynurenate blockade of glutamate neurotoxicity in cell culture. , 1989, European journal of pharmacology.

[12]  E. Costa,et al.  Kynurenate and 2-amino-5-phosphonovalerate interact with multiple binding sites of the N-methyl-d-aspartate-sensitive glutamate receptor domain , 1989, Neuroscience Letters.

[13]  Joseph B. Martin,et al.  Differential sparing of somatostatin‐neuropeptide y and cholinergic neurons following striatal excitotoxin lesions , 1989, Synapse.

[14]  T. Stone,et al.  NMDA receptors and ligands in the vertebrate CNS , 1988, Progress in Neurobiology.

[15]  F. Moroni,et al.  INCREASED KYNURENIC ACID LEVELS IN HUNTINGTON'S DISEASE , 1988, The Lancet.

[16]  G. Lombardi,et al.  Kynurenic acid is present in the rat brain and its content increases during development and aging processes , 1988, Neuroscience Letters.

[17]  C. Grossman,et al.  6,7-Dinitro-quinoxaline-2,3-dion and 6-nitro,7-cyano-quinoxaline-2,3-dion antagonise responses to NMDA in the rat spinal cord via an action at the strychnine-insensitive glycine receptor. , 1988, European journal of pharmacology.

[18]  A. Foster.  Quisqualate receptor antagonists , 1988, Nature.

[19]  G. Westbrook,et al.  Modulation of excitatory synaptic transmission by glycine and zinc in cultures of mouse hippocampal neurons , 1988, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[20]  C. Grossman,et al.  Kynurenic acid antagonises responses to NMDA via an action at the strychnine-insensitive glycine receptor. , 1988, European journal of pharmacology.

[21]  R. Dingledine,et al.  Requirement for glycine in activation of NMDA-receptors expressed in Xenopus oocytes. , 1988, Science.

[22]  S N Davies,et al.  Quinoxalinediones: potent competitive non-NMDA glutamate receptor antagonists. , 1988, Science.

[23]  C. Grossman,et al.  Kynurenate and FG9041 have both competitive and non-competitive antagonist actions at excitatory amino acid receptors. , 1988, European journal of pharmacology.

[24]  G. Lombardi,et al.  Presence of Kynurenic Acid in the Mammalian Brain , 1988, Journal of neurochemistry.

[25]  R. Schwarcz,et al.  Identification and quantification of kynurenic acid in human brain tissue , 1988, Brain Research.

[26]  G. Lombardi,et al.  Identification and measurement of kynurenic acid in the rat brain and other organs. , 1988, Analytical biochemistry.

[27]  K. Shibata,et al.  Fluorimetric micro-determination of kynurenic acid, an endogenous blocker of neurotoxicity, by high-performance liquid chromatography. , 1988, Journal of chromatography.

[28]  M. Beal,et al.  EC array sensor concepts and data. , 1987, Life sciences.

[29]  P. Ascher,et al.  Glycine potentiates the NMDA response in cultured mouse brain neurons , 1987, Nature.

[30]  Joseph B. Martin,et al.  Replication of the neurochemical characteristics of Huntington's disease by quinolinic acid , 1986, Nature.

[31]  Y. Ben-Ari,et al.  Excitatory Amino Acids and Epilepsy , 1986, Advances in Experimental Medicine and Biology.

[32]  T. Wieloch.  Hypoglycemia-induced neuronal damage prevented by an N-methyl-D-aspartate antagonist. , 1985, Science.

[33]  T. Stone,et al.  Quinolinic acid and other kynurenines in the central nervous system , 1985, Neuroscience.

[34]  T. Stone,et al.  Actions of kynurenic acid and quinolinic acid in the rat hippocampus in vivo , 1985, Experimental Neurology.

[35]  B. Meldrum,et al.  Blockade of N-methyl-D-aspartate receptors may protect against ischemic damage in the brain. , 1984, Science.

[36]  W. Matson,et al.  n-Electrode three-dimensional liquid chromatography with electrochemical detection for determination of neurotransmitters. , 1984, Clinical chemistry.

[37]  R. Schwarcz,et al.  Kynurenic acid blocks neurotoxicity and seizures induced in rats by the related brain metabolite quinolinic acid , 1984, Neuroscience Letters.

[38]  R. Schwarcz,et al.  II: Excitotoxic models for neurodegenerative disorders , 1984 .

[39]  Carl W. Cotman,et al.  Kynurenic acid inhibits synaptic and acidic amino acid-induced responses in the rat hippocampus and spinal cord , 1983, Brain Research.

[40]  T. Stone,et al.  An iontophoretic investigation of the actions of convulsant kynurenines and their interaction with the endogenous excitant quinolinic acid , 1982, Brain Research.

[41]  M. Nakamura,et al.  Crystallization and characterization of human liver kynurenine--glyoxylate aminotransferase. Identity with alanine--glyoxylate aminotransferase and serine--pyruvate aminotransferase. , 1980, The Biochemical journal.

[42]  E. Tomlinson,et al.  Ion-pair high-performance liquid chromatography , 1978 .

[43]  E. Spokes,et al.  Post‐mortem stability of dopamine. glutamate decarboxylase and choline acetyltransferase in the mouse brain under conditions simulating the handling of human autopsy material , 1978, Journal of neurochemistry.

[44]  A. Sherman,et al.  SYNTHESIS AND METABOLISM OF l‐KYNURENINE IN RAT BRAIN , 1978, Journal of neurochemistry.

[45]  R. Gloor,et al.  Practical Aspects off Reverse Phase Ion Pair Chromatography , 1977 .

[46]  J. Edwards,et al.  HUNTINGTON'S CHOREA , 1977, The Lancet.

[47]  P. Mcgeer,et al.  Duplication of biochemical changes of Huntington's chorea by intrastriatal injections of glutamic and kainic acids , 1976, Nature.

[48]  J. Coyle,et al.  Lesion of striatal neurons with kainic acid provides a model for Huntington's chorea , 1976, Nature.

[49]  T. Noguchi,et al.  Kynurenine pyruvate transaminase in rat brain , 1974, Journal of neurochemistry.

[50]  E. Gal,et al.  Cerebral tryptophan‐2,3‐dioxygenase (pyrrolase) and its induction in rat brain , 1974, Journal of neurochemistry.

[51]  T. Noguchi,et al.  Kynurenine pyruvate transaminase and its inhibitor in rat intestine. , 1973, Life sciences.

[52]  S. Udenfriend,et al.  Fluorometric assay of proteins in the nanogram range. , 1973, Archives of biochemistry and biophysics.

[53]  M. Mason,et al.  Estrogen-enzyme interactions: Inhibition and protection of kynurenine transaminase by the sulfate esters of diethylstilbestrol, estradiol, and estrone. , 1960, The Journal of biological chemistry.

[54]  M. Mason.  Kynurenine transaminase: a study of inhibitors and their relationship to the active site. , 1959, The Journal of biological chemistry.

[55]  M. Mason.  Kynurenine transaminase of rat kidney; a study of coenzyme dissociation. , 1957, The Journal of biological chemistry.

[56]  M. Mason.  The kynurenine transaminase of rat kidney. , 1954, The Journal of biological chemistry.

[57]  C. Heidelberger,et al.  Tryptophan metabolism; concerning the mechanism of the mammalian conversion of tryptophan into kynurenine, kynurenic acid, and nicotinic acid. , 1949, The Journal of biological chemistry.

[58]  A. Homer.  THE CONSTITUTION OF KYNURENIC ACID , 1914 .

[59]  A. Ellinger.  Die Entstehung der Kynurensäure. , 1905 .