Promiscuous enzyme-catalyzed regioselective Michael addition of purine derivatives to α,β-unsaturated carbonyl compounds in organic solvent

[1]  M. Reetz,et al.  Alternate-site enzyme promiscuity. , 2007, Angewandte Chemie.

[2]  C. Qian,et al.  Promiscuous acylase-catalyzed aza-Michael additions of aromatic N-heterocycles in organic solvent , 2007 .

[3]  K. Hult,et al.  Enzyme promiscuity: mechanism and applications. , 2007, Trends in biotechnology.

[4]  H. Ohta,et al.  The Aldol Type Reaction Catalyzed by Arylmalonate Decarboxylase —A Decarboxylase can Catalyze an Entirely Different Reaction, Aldol Reaction— , 2007 .

[5]  G. Qu,et al.  Microwave-Promoted Michael Addition in Neat Water: A Rapid, Efficient and Green Method for the Preparation of Acyclic Nucleosides , 2007 .

[6]  G. Qu,et al.  Microwave assisted synthesis of 6-Substituted aminopurine analogs in water , 2006 .

[7]  Dan S. Tawfik,et al.  Enzyme promiscuity: evolutionary and mechanistic aspects. , 2006, Current opinion in chemical biology.

[8]  Xianfu Lin,et al.  Hydrolase-catalyzed Michael addition of imidazoles to acrylic monomers in organic medium. , 2006, Journal of biotechnology.

[9]  K. Hult,et al.  Fast carbon-carbon bond formation by a promiscuous lipase. , 2005, Journal of the American Chemical Society.

[10]  Jianming Xu,et al.  Two-step sequential synthesis of pyrimidine derivatives containing a sugar branch via combining of enzymatic Michael addition/acylation , 2005 .

[11]  G. Qu,et al.  Solvent-Free Synthesis of 2′,3′,5′-Tri-O-acetyl-2,6-dichloropurine Nucleoside Catalyzed by p-Toluenesulfonic Acid Using Microwave. , 2005 .

[12]  G. Qu,et al.  Microwave Assisted Synthesis of N-(ethoxycarbonylmethyl)-nucleobases: Building Blocks for PNAs , 2005 .

[13]  T. Brinck,et al.  Exploring the Active‐Site of a Rationally Redesigned Lipase for Catalysis of Michael‐Type Additions , 2005, Chembiochem : a European journal of chemical biology.

[14]  Babak Mokhtari,et al.  Microwave-assisted Michael addition of some pyrimidine and purine nucleobases with α, β-unsaturated esters: A rapid entry into carboacyclic nucleoside synthesis , 2005 .

[15]  U. Bornscheuer,et al.  Catalytic promiscuity in biocatalysis: using old enzymes to form new bonds and follow new pathways. , 2004, Angewandte Chemie.

[16]  I. Alfonso,et al.  Lipase catalysed Michael addition of secondary amines to acrylonitrile. , 2004, Chemical communications.

[17]  Xianfu Lin,et al.  Michael addition of imidazole with acrylates catalyzed by alkaline protease from Bacillus subtilis in organic media , 2004, Biotechnology Letters.

[18]  D. Hilvert,et al.  Conversion of a PLP-dependent racemase into an aldolase by a single active site mutation. , 2003, Journal of the American Chemical Society.

[19]  S. Copley.  Enzymes with extra talents: moonlighting functions and catalytic promiscuity. , 2003, Current opinion in chemical biology.

[20]  F. Huet,et al.  Rapid access to acyclic nucleosides via conjugate addition , 2003 .

[21]  E. De Clercq,et al.  Synthesis and antitumor activities of novel pyrimidine derivatives of 2,3-O,O-dibenzyl-6-deoxy-L-ascorbic acid and 4,5-didehydro-5,6- dideoxy-L-ascorbic acid. , 2000, Journal of medicinal chemistry.

[22]  R. Schmidt,et al.  Convenient Synthesis of Nucleosides of 2-Deoxy-2-nitro-D-galactose andN-Acetyl-D-galactosamine , 2000 .

[23]  E. De Clercq,et al.  Novel pyrimidine and purine derivatives of L-ascorbic acid: synthesis and biological evaluation. , 1999, Journal of medicinal chemistry.

[24]  D. Herschlag,et al.  Catalytic promiscuity and the evolution of new enzymatic activities. , 1999, Chemistry & biology.

[25]  D. Liotta,et al.  Nitrogen Glycosylation Reactions Involving Pyrimidine and Purine Nucleoside Bases with Furanoside Sugars , 1995 .

[26]  V. Nair,et al.  Antiviral activities of isometric dideoxynucleosides of D- and L-related stereochemistry , 1995, Antimicrobial agents and chemotherapy.

[27]  R. H. Berg,et al.  Synthesis of Peptide Nucleic Acid Monomers Containing the Four Natural Nucleobases: Thymine, Cytosine, Adenine, and Guanine and Their Oligomerization , 1994 .

[28]  D. Huryn,et al.  AIDS-driven nucleoside chemistry. , 1992 .

[29]  G. Geen,et al.  Regiospecific Michael additions with 2-aminopurines , 1992 .

[30]  S. Megati,et al.  Unsaturated phosphonates as acyclic nucleotide analogs. Anomalous Michaelis-Arbuzov and Michaelis-Becker reactions with multiple bond systems , 1992 .

[31]  Erik De Clercq,et al.  HIV inhibitors targeted at the reverse transcriptase. , 1992 .

[32]  H. Mitsuya,et al.  Molecular targets for AIDS therapy. , 1990, Science.

[33]  G. Geen,et al.  The effect of the c-6 substituent on the regioselectivity of n-alkylation of 2-aminopurines , 1990 .

[34]  J. Kjellberg,et al.  Studies on the Alkylation of Derivatives of Guanines , 1989 .

[35]  D. R. Haines,et al.  Synthesis and biological activity of unsaturated carboacyclic purine nucleoside analogues. , 1987, Journal of medicinal chemistry.

[36]  T. Kitazume,et al.  Synthesis of optically active trifluorinated compounds: asymmetric Michael addition with hydrolytic enzymes , 1986 .

[37]  B. R. Baker,et al.  A Michael Addition with 6-Chloropurine1 , 1965 .