The biological functions of T helper 17 cell effector cytokines in inflammation.

[1]  R. Locksley The Roaring Twenties. , 2008, Immunity.

[2]  S. Sidhu,et al.  Regulation of a Late Phase of T Cell Polarity and Effector Functions by Crtam , 2008, Cell.

[3]  M. Fei,et al.  IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia , 2008, Nature Medicine.

[4]  S. Sa,et al.  Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens , 2008, Nature Medicine.

[5]  S. Brand,et al.  Linking genetic susceptibility to Crohn's disease with Th17 cell function: IL‐22 serum levels are increased in Crohn's disease and correlate with disease activity and IL23R genotype status , 2008, Inflammatory bowel diseases.

[6]  L. Fouser,et al.  IL-22 is required for Th17 cell-mediated pathology in a mouse model of psoriasis-like skin inflammation. , 2008, The Journal of clinical investigation.

[7]  R. Xavier,et al.  IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis. , 2008, The Journal of clinical investigation.

[8]  Robert W. Williams,et al.  Interleukin 17–producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice , 2008, Nature Immunology.

[9]  U. Grohmann,et al.  Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease , 2008, Nature.

[10]  B. Becher,et al.  IL-22 Is Expressed by Th17 Cells in an IL-23-Dependent Fashion, but Not Required for the Development of Autoimmune Encephalomyelitis1 , 2007, The Journal of Immunology.

[11]  Y. Li,et al.  Cytokine-Mediated Regulation of Human B Cell Differentiation into Ig-Secreting Cells: Predominant Role of IL-21 Produced by CXCR5+ T Follicular Helper Cells1 , 2007, The Journal of Immunology.

[12]  L. Fouser,et al.  An IL-17F/A Heterodimer Protein Is Produced by Mouse Th17 Cells and Induces Airway Neutrophil Recruitment , 2007, The Journal of Immunology.

[13]  Robert M. Anthony,et al.  Protective immune mechanisms in helminth infection , 2007, Nature Reviews Immunology.

[14]  R. Wu,et al.  Requirement for Both JAK-Mediated PI3K Signaling and ACT1/TRAF6/TAK1-Dependent NF-κB Activation by IL-17A in Enhancing Cytokine Expression in Human Airway Epithelial Cells1 , 2007, The Journal of Immunology.

[15]  A. Murphy,et al.  Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammation. , 2007, Immunity.

[16]  T. Macdonald,et al.  Interleukin 21 contributes to the mucosal T helper cell type 1 response in coeliac disease , 2007, Gut.

[17]  Scott R. Presnell,et al.  Identification of the IL-17 Receptor Related Molecule IL-17RC as the Receptor for IL-17F , 2007, The Journal of Immunology.

[18]  Nathalie Arbour,et al.  Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation , 2007, Nature Medicine.

[19]  Francesco Bistoni,et al.  IL‐23 and the Th17 pathway promote inflammation and impair antifungal immune resistance , 2007, European journal of immunology.

[20]  T. Hamilton,et al.  IL-17 Enhances Chemokine Gene Expression through mRNA Stabilization1 , 2007, The Journal of Immunology.

[21]  D. Levy,et al.  IL-6 programs TH-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways , 2007, Nature Immunology.

[22]  Kathleen M. Smith,et al.  Development, cytokine profile and function of human interleukin 17–producing helper T cells , 2007, Nature Immunology.

[23]  P. Lipsky,et al.  Genetic association of interleukin-21 polymorphisms with systemic lupus erythematosus , 2007, Annals of the rheumatic diseases.

[24]  L. Cosmi,et al.  Phenotypic and functional features of human Th17 cells , 2007, The Journal of experimental medicine.

[25]  Terry B. Strom,et al.  IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells , 2007, Nature.

[26]  A. D. Panopoulos,et al.  Essential autocrine regulation by IL-21 in the generation of inflammatory T cells , 2007, Nature.

[27]  M. Brahic,et al.  Interleukin 22 Is a Candidate Gene for Tmevp3, a Locus Controlling Theiler's Virus-Induced Neurological Diseases , 2007, Genetics.

[28]  P. Deloukas,et al.  A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21 , 2007, Nature Genetics.

[29]  M. Romano,et al.  IL-21 Is Highly Produced in Helicobacter pylori-Infected Gastric Mucosa and Promotes Gelatinases Synthesis1 , 2007, The Journal of Immunology.

[30]  K. Asadullah,et al.  IL-22 Induces Lipopolysaccharide-Binding Protein in Hepatocytes: A Potential Systemic Role of IL-22 in Crohn’s Disease , 2007, The Journal of Immunology.

[31]  R. Locksley,et al.  IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge , 2007, Nature Immunology.

[32]  R. Kastelein,et al.  Discovery and biology of IL-23 and IL-27: related but functionally distinct regulators of inflammation. , 2007, Annual review of immunology.

[33]  R. D. Hatton,et al.  IL-17 family cytokines and the expanding diversity of effector T cell lineages. , 2007, Annual review of immunology.

[34]  M. Collins,et al.  IL-21 Has a Pathogenic Role in a Lupus-Prone Mouse Model and Its Blockade with IL-21R.Fc Reduces Disease Progression , 2007, The Journal of Immunology.

[35]  D. Hommes,et al.  Comparative analysis of colonic gene expression of three experimental colitis models mimicking inflammatory bowel disease , 2007, Inflammatory bowel diseases.

[36]  V. Tuohy,et al.  The adaptor Act1 is required for interleukin 17–dependent signaling associated with autoimmune and inflammatory disease , 2007, Nature Immunology.

[37]  Mark J. Smyth,et al.  IL-21 Is Produced by NKT Cells and Modulates NKT Cell Activation and Cytokine Production1 , 2007, The Journal of Immunology.

[38]  James G. Krueger,et al.  Pathogenesis and therapy of psoriasis , 2007, Nature.

[39]  S. Sa,et al.  The Effects of IL-20 Subfamily Cytokines on Reconstituted Human Epidermis Suggest Potential Roles in Cutaneous Innate Defense and Pathogenic Adaptive Immunity in Psoriasis , 2007, The Journal of Immunology.

[40]  M. Lebwohl,et al.  A human interleukin-12/23 monoclonal antibody for the treatment of psoriasis. , 2007, The New England journal of medicine.

[41]  P. Valdez,et al.  Interleukin-22, a TH17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis , 2007, Nature.

[42]  Steven J. Schrodi,et al.  A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes. , 2007, American journal of human genetics.

[43]  J. Kolls,et al.  IL-23 mediates inflammatory responses to mucoid Pseudomonas aeruginosa lung infection in mice. , 2007, American journal of physiology. Lung cellular and molecular physiology.

[44]  B. Holzmann,et al.  Inhibition of Interleukin-22 Attenuates Bacterial Load and Organ Failure during Acute Polymicrobial Sepsis , 2007, Infection and Immunity.

[45]  D. Missé,et al.  IL-22 Participates in an Innate Anti-HIV-1 Host-Resistance Network through Acute-Phase Protein Induction1 , 2007, The Journal of Immunology.

[46]  C. Dong,et al.  Act1 Adaptor Protein Is an Immediate and Essential Signaling Component of Interleukin-17 Receptor* , 2006, Journal of Biological Chemistry.

[47]  Qiang Tian,et al.  Expression and regulation of IL-22 in the IL-17-producing CD4+ T lymphocytes , 2006, Cell Research.

[48]  L. Fouser,et al.  Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides , 2006, The Journal of experimental medicine.

[49]  J. Miyazaki,et al.  Hydrodynamic-Based Delivery of an Interleukin-22-Ig Fusion Gene Ameliorates Experimental Autoimmune Myocarditis in Rats1 , 2006, The Journal of Immunology.

[50]  Zihua Hu,et al.  Identification of Common Transcriptional Regulatory Elements in Interleukin-17 Target Genes* , 2006, Journal of Biological Chemistry.

[51]  L. Hooper,et al.  Symbiotic Bacteria Direct Expression of an Intestinal Bactericidal Lectin , 2006, Science.

[52]  F. Powrie,et al.  Differential activity of IL-12 and IL-23 in mucosal and systemic innate immune pathology. , 2006, Immunity.

[53]  J. Derry,et al.  Cutting Edge: Interleukin 17 Signals through a Heteromeric Receptor Complex , 2006, The Journal of Immunology.

[54]  S. Nakae,et al.  IL-17 Plays an Important Role in the Development of Experimental Autoimmune Encephalomyelitis1 , 2006, The Journal of Immunology.

[55]  Q. Zhong,et al.  IL-17 Receptor Knockout Mice Have Enhanced Myelotoxicity and Impaired Hemopoietic Recovery Following Gamma Irradiation , 2006, The Journal of Immunology.

[56]  T. Macdonald,et al.  Control of matrix metalloproteinase production in human intestinal fibroblasts by interleukin 21 , 2006, Gut.

[57]  J. Kolls,et al.  Critical role of IL‐17 receptor signaling in acute TNBS‐induced colitis , 2006, Inflammatory bowel diseases.

[58]  T. Mcclanahan,et al.  IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6. , 2006, The Journal of clinical investigation.

[59]  K. Asadullah,et al.  IL‐22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis , 2006, European journal of immunology.

[60]  R. D. Hatton,et al.  Transforming growth factor-β induces development of the TH17 lineage , 2006, Nature.

[61]  K. Herrmann,et al.  IL-22 is increased in active Crohn's disease and promotes proinflammatory gene expression and intestinal epithelial cell migration. , 2006, American journal of physiology. Gastrointestinal and liver physiology.

[62]  J. Shellito,et al.  Divergent roles of IL-23 and IL-12 in host defense against Klebsiella pneumoniae , 2005, The Journal of experimental medicine.

[63]  A. Takayanagi,et al.  Interleukin-22, a member of the IL-10 subfamily, induces inflammatory responses in colonic subepithelial myofibroblasts. , 2005, Gastroenterology.

[64]  C. Brooks,et al.  Multiple Cytokines Regulate the NK Gene Complex-Encoded Receptor Repertoire of Mature NK Cells and T Cells1 , 2005, The Journal of Immunology.

[65]  J. Kolls,et al.  Role of IL-17A, IL-17F, and the IL-17 Receptor in Regulating Growth-Related Oncogene-α and Granulocyte Colony-Stimulating Factor in Bronchial Epithelium: Implications for Airway Inflammation in Cystic Fibrosis 1 , 2005, The Journal of Immunology.

[66]  J. Derry,et al.  Nectin-like Protein 2 Defines a Subset of T-cell Zone Dendritic Cells and Is a Ligand for Class-I-restricted T-cell-associated Molecule*♦ , 2005, Journal of Biological Chemistry.

[67]  R. Copley,et al.  A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity , 2005, Nature.

[68]  K. Hiromura,et al.  Expression of interleukin-22 in rheumatoid arthritis: potential role as a proinflammatory cytokine. , 2005, Arthritis and rheumatism.

[69]  A. Gurney,et al.  IL-22 Inhibits Epidermal Differentiation and Induces Proinflammatory Gene Expression and Migration of Human Keratinocytes1 , 2005, The Journal of Immunology.

[70]  U. Müller-Ladner,et al.  Expression of interleukin-21 receptor in epidermis from patients with systemic sclerosis. , 2005, Arthritis and rheumatism.

[71]  T. Macdonald,et al.  Interleukin-21 enhances T-helper cell type I signaling and interferon-gamma production in Crohn's disease. , 2005, Gastroenterology.

[72]  K. Ley,et al.  Phagocytosis of apoptotic neutrophils regulates granulopoiesis via IL-23 and IL-17. , 2005, Immunity.

[73]  F. Shi,et al.  Differential Effects of IL-21 during Initiation and Progression of Autoimmunity against Neuroantigen1 , 2005, The Journal of Immunology.

[74]  T. Mcclanahan,et al.  IL-23 drives a pathogenic T cell population that induces autoimmune inflammation , 2005, The Journal of experimental medicine.

[75]  J. Berzofsky,et al.  Synergy of IL-21 and IL-15 in regulating CD8+ T cell expansion and function , 2005, The Journal of experimental medicine.

[76]  J. Schwartzman,et al.  Interleukin-17/Interleukin-17 Receptor-Mediated Signaling Is Important for Generation of an Optimal Polymorphonuclear Response against Toxoplasma gondii Infection , 2005, Infection and Immunity.

[77]  Shizuo Akira,et al.  Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron , 2004, Nature.

[78]  A. Gottlieb,et al.  A phase I study evaluating the safety, pharmacokinetics, and clinical response of a human IL-12 p40 antibody in subjects with plaque psoriasis. , 2004, The Journal of investigative dermatology.

[79]  M. Grusby,et al.  Biology of IL‐21 and the IL‐21 receptor , 2004, Immunological reviews.

[80]  P. Lipsky,et al.  Regulation of B Cell Differentiation and Plasma Cell Generation by IL-21, a Novel Inducer of Blimp-1 and Bcl-61 , 2004, The Journal of Immunology.

[81]  R. Wu,et al.  IL-17 Markedly Up-Regulates β-Defensin-2 Expression in Human Airway Epithelium via JAK and NF-κB Signaling Pathways1 , 2004, The Journal of Immunology.

[82]  K. Asadullah,et al.  IL-22 increases the innate immunity of tissues. , 2004, Immunity.

[83]  P. Schwarzenberger,et al.  Requirement of interleukin-17A for systemic anti-Candida albicans host defense in mice. , 2004, The Journal of infectious diseases.

[84]  C. Mackay,et al.  T Follicular Helper Cells Express a Distinctive Transcriptional Profile, Reflecting Their Role as Non-Th1/Th2 Effector Cells That Provide Help for B Cells1 , 2004, The Journal of Immunology.

[85]  T. Malek,et al.  Distinct Activation Signals Determine whether IL-21 Induces B Cell Costimulation, Growth Arrest, or Bim-Dependent Apoptosis1 , 2004, The Journal of Immunology.

[86]  R. Sun,et al.  Interleukin 22 (IL‐22) plays a protective role in T cell‐mediated murine hepatitis: IL‐22 is a survival factor for hepatocytes via STAT3 activation , 2004, Hepatology.

[87]  N. Sarvetnick,et al.  Homeostatic Expansion of T Cells during Immune Insufficiency Generates Autoimmunity , 2004, Cell.

[88]  L. Armstrong,et al.  Interleukin-22: a potential immunomodulatory molecule in the lung. , 2004, American journal of respiratory cell and molecular biology.

[89]  C. D. Krause,et al.  Interleukin-10 and related cytokines and receptors. , 2004, Annual review of immunology.

[90]  Lauren Cohn,et al.  Asthma: mechanisms of disease persistence and progression. , 2004, Annual review of immunology.

[91]  S. Nutt,et al.  IL-21 Induces the Functional Maturation of Murine NK Cells 1 , 2004, The Journal of Immunology.

[92]  L. Joosten,et al.  Treatment with a neutralizing anti-murine interleukin-17 antibody after the onset of collagen-induced arthritis reduces joint inflammation, cartilage destruction, and bone erosion. , 2004, Arthritis and rheumatism.

[93]  Ju-Young Kim,et al.  IL-17 induces production of IL-6 and IL-8 in rheumatoid arthritis synovial fibroblasts via NF-κB- and PI3-kinase/Akt-dependent pathways , 2004, Arthritis research & therapy.

[94]  M. Dhodapkar,et al.  Increased Expression of Interleukin 23 p19 and p40 in Lesional Skin of Patients with Psoriasis Vulgaris , 2004, The Journal of experimental medicine.

[95]  W. Leonard,et al.  In vivo antitumor activity of interleukin 21 mediated by natural killer cells. , 2003, Cancer research.

[96]  T. Mcclanahan,et al.  Divergent Pro- and Antiinflammatory Roles for IL-23 and IL-12 in Joint Autoimmune Inflammation , 2003, The Journal of experimental medicine.

[97]  D. Foster,et al.  Interleukin-21 inhibits dendritic cell activation and maturation. , 2003, Blood.

[98]  L. Moretta,et al.  IL‐21 induces both rapid maturation of human CD34+ cell precursors towards NK cells and acquisition of surface killer Ig‐like receptors , 2003, European journal of immunology.

[99]  R. Paus,et al.  Interleukin-21 inhibits dendritic cell-mediated T cell activation and induction of contact hypersensitivity in vivo. , 2003, The Journal of investigative dermatology.

[100]  M. Zago,et al.  The Profile of Gene Expression of Human Marrow Mesenchymal Stem Cells , 2003, Stem cells.

[101]  D. Foster,et al.  Cytokine requirements for the growth and development of mouse NK cells in vitro , 2003, Journal of leukocyte biology.

[102]  G. Bouma,et al.  The immunological and genetic basis of inflammatory bowel disease , 2003, Nature Reviews Immunology.

[103]  Y. Ho,et al.  Stimulation of Airway Mucin Gene Expression by Interleukin (IL)-17 through IL-6 Paracrine/Autocrine Loop* , 2003, The Journal of Biological Chemistry.

[104]  E. Lubberts The role of IL-17 and family members in the pathogenesis of arthritis. , 2003, Current opinion in investigational drugs.

[105]  J. Lötvall,et al.  Endogenous IL-17 as a Mediator of Neutrophil Recruitment Caused by Endotoxin Exposure in Mouse Airways1 , 2003, The Journal of Immunology.

[106]  Frank Eisenhaber,et al.  The STIR-domain superfamily in signal transduction, development and immunity. , 2003, Trends in biochemical sciences.

[107]  T. Moseley,et al.  Interleukin-17 family and IL-17 receptors. , 2003, Cytokine & growth factor reviews.

[108]  J. Lötvall,et al.  Pharmacological modulation of interleukin-17-induced GCP-2-, GRO-alpha- and interleukin-8 release in human bronchial epithelial cells. , 2003, European journal of pharmacology.

[109]  D. Kasper,et al.  CD4+ T Cells Mediate Abscess Formation in Intra-abdominal Sepsis by an IL-17-Dependent Mechanism 1 , 2003, The Journal of Immunology.

[110]  R. Kastelein,et al.  Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain , 2003, Nature.

[111]  A. Gurney,et al.  Interleukin-23 Promotes a Distinct CD4 T Cell Activation State Characterized by the Production of Interleukin-17* , 2003, The Journal of Biological Chemistry.

[112]  A. Andoh,et al.  Increased expression of interleukin 17 in inflammatory bowel disease , 2003, Gut.

[113]  Kotaro Suzuki,et al.  Interleukin 21 prevents antigen-induced IgE production by inhibiting germ line Cε transcription of IL-4–stimulated B cells , 2002 .

[114]  A. Sher,et al.  A Critical Role for IL-21 in Regulating Immunoglobulin Production , 2002, Science.

[115]  D. Sacks,et al.  The immunology of susceptibility and resistance to Leishmania major in mice , 2002, Nature Reviews Immunology.

[116]  H. Yssel,et al.  IL-22, in contrast to IL-10, does not induce Ig production, due to absence of a functional IL-22 receptor on activated human B cells. , 2002, International immunology.

[117]  A. Satoskar,et al.  Interleukin 21 Is a T Helper (Th) Cell 2 Cytokine that Specifically Inhibits the Differentiation of Naive Th Cells into Interferon γ–producing Th1 Cells , 2002, The Journal of experimental medicine.

[118]  D. Foster,et al.  IL-21 Up-Regulates the Expression of Genes Associated with Innate Immunity and Th1 Response1 , 2002, The Journal of Immunology.

[119]  Diane Lejeune,et al.  Interleukin-22 (IL-22) Activates the JAK/STAT, ERK, JNK, and p38 MAP Kinase Pathways in a Rat Hepatoma Cell Line , 2002, The Journal of Biological Chemistry.

[120]  J. Renauld,et al.  Crystal structure of recombinant human interleukin-22. , 2002, Structure.

[121]  K. Weinberg,et al.  The Common γ Chain (γc) Is a Required Signaling Component of the IL-21 Receptor and Supports IL-21-Induced Cell Proliferation via JAK3† , 2002 .

[122]  R. Coffman,et al.  New IL-17 Family Members Promote Th1 or Th2 Responses in the Lung: In Vivo Function of the Novel Cytokine IL-251 , 2002, The Journal of Immunology.

[123]  K. Asadullah,et al.  Cutting Edge: Immune Cells as Sources and Targets of the IL-10 Family Members? , 2002, The Journal of Immunology.

[124]  Katie Chan,et al.  Interleukin-17 stimulates the expression of interleukin-8, growth-related oncogene-alpha, and granulocyte-colony-stimulating factor by human airway epithelial cells. , 2002, American journal of respiratory cell and molecular biology.

[125]  Jorge R. Oksenberg,et al.  Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis , 2002, Nature Medicine.

[126]  M. Collins,et al.  IL-21 limits NK cell responses and promotes antigen-specific T cell activation: a mediator of the transition from innate to adaptive immunity. , 2002, Immunity.

[127]  S. Kotenko,et al.  Interleukin 24 (MDA-7/MOB-5) Signals through Two Heterodimeric Receptors, IL-22R1/IL-20R2 and IL-20R1/IL-20R2* , 2002, The Journal of Biological Chemistry.

[128]  B. Kirkham,et al.  Reduction of joint inflammation and bone erosion in rat adjuvant arthritis by treatment with interleukin-17 receptor IgG1 Fc fusion protein. , 2002, Arthritis and rheumatism.

[129]  T. Moseley,et al.  Soluble and Transmembrane Isoforms of Novel Interleukin-17 Receptor-like Protein by RNA Splicing and Expression in Prostate Cancer* , 2002, The Journal of Biological Chemistry.

[130]  K. Ley,et al.  Increased granulopoiesis through interleukin-17 and granulocyte colony-stimulating factor in leukocyte adhesion molecule-deficient mice. , 2001, Blood.

[131]  A. Gurney,et al.  Acinar cells of the pancreas are a target of interleukin-22. , 2001, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

[132]  M. Kawaguchi,et al.  Modulation of bronchial epithelial cells by IL-17. , 2001, The Journal of allergy and clinical immunology.

[133]  G. Sledge,et al.  Cutting Edge: IL-17F, a Novel Cytokine Selectively Expressed in Activated T Cells and Monocytes, Regulates Angiogenesis and Endothelial Cell Cytokine Production1 , 2001, The Journal of Immunology.

[134]  R. Kelley,et al.  IL‐17s adopt a cystine knot fold: structure and activity of a novel cytokine, IL‐17F, and implications for receptor binding , 2001, The EMBO journal.

[135]  D. Lejeune,et al.  Cutting Edge: STAT Activation By IL-19, IL-20 and mda-7 Through IL-20 Receptor Complexes of Two Types1 , 2001, The Journal of Immunology.

[136]  J. Shellito,et al.  Requirement of Interleukin 17 Receptor Signaling for Lung Cxc Chemokine and Granulocyte Colony-Stimulating Factor Expression, Neutrophil Recruitment, and Host Defense , 2001, The Journal of experimental medicine.

[137]  Scott R. Presnell,et al.  A soluble class II cytokine receptor, IL-22RA2, is a naturally occurring IL-22 antagonist , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[138]  H. Asao,et al.  Cutting Edge: The Common γ-Chain Is an Indispensable Subunit of the IL-21 Receptor Complex1 , 2001, The Journal of Immunology.

[139]  D. Lejeune,et al.  Cloning and Characterization of IL-22 Binding Protein, a Natural Antagonist of IL-10-Related T Cell-Derived Inducible Factor/IL-22 , 2001, The Journal of Immunology.

[140]  S. Pestka,et al.  Identification, Cloning, and Characterization of a Novel Soluble Receptor That Binds IL-22 and Neutralizes Its Activity1 2 , 2001, The Journal of Immunology.

[141]  J. Lötvall,et al.  IL‐17‐induced cytokine release in human bronchial epithelial cells in vitro: role of mitogen‐activated protein (MAP) kinases , 2001, British journal of pharmacology.

[142]  S. Pestka,et al.  Identification of the Functional Interleukin-22 (IL-22) Receptor Complex , 2001, The Journal of Biological Chemistry.

[143]  D. Conklin,et al.  Interleukin 20 Discovery, Receptor Identification, and Role in Epidermal Function , 2001, Cell.

[144]  M. Byrne,et al.  Microbial Lipopeptides Induce the Production of IL-17 in Th Cells1 , 2000, The Journal of Immunology.

[145]  Scott R. Presnell,et al.  Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function , 2000, Nature.

[146]  J Wagner,et al.  Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. , 2000, Immunity.

[147]  W. Leonard,et al.  Cloning of a type I cytokine receptor most related to the IL-2 receptor beta chain. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[148]  Zemin Zhang,et al.  Interleukin (IL)-22, a Novel Human Cytokine That Signals through the Interferon Receptor-related Proteins CRF2–4 and IL-22R* , 2000, The Journal of Biological Chemistry.

[149]  J. Renauld,et al.  Human interleukin-10-related T cell-derived inducible factor: molecular cloning and functional characterization as an hepatocyte-stimulating factor. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[150]  L. Glimcher,et al.  Lineage commitment in the immune system: the T helper lymphocyte grows up. , 2000, Genes & development.

[151]  J. Kolls,et al.  Requirement of Endogenous Stem Cell Factor and Granulocyte-Colony-Stimulating Factor for IL-17-Mediated Granulopoiesis1 , 2000, The Journal of Immunology.

[152]  Jamila Louahed,et al.  Cloning and Characterization of IL-10-Related T Cell-Derived Inducible Factor (IL-TIF), a Novel Cytokine Structurally Related to IL-10 and Inducible by IL-91 , 2000, The Journal of Immunology.

[153]  J. Lötvall,et al.  Neutrophil recruitment by human IL-17 via C-X-C chemokine release in the airways. , 1999, Journal of immunology.

[154]  A. Miller,et al.  IL-17 stimulates granulopoiesis in mice: use of an alternate, novel gene therapy-derived method for in vivo evaluation of cytokines. , 1998, Journal of immunology.

[155]  R. de Waal Malefyt,et al.  Interleukin-17 and interferon-gamma synergize in the enhancement of proinflammatory cytokine production by human keratinocytes. , 1998, The Journal of investigative dermatology.

[156]  S. Narula,et al.  Regulation of granulocyte colony-stimulating factor gene expression by interleukin-17. , 1998, Immunology letters.

[157]  J. Todd,et al.  Mapping of the IDDM Locus Idd3 to a 0.35-cM Interval Containing the Interleukin-2 Gene , 1997, Diabetes.

[158]  J. Banchereau,et al.  T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines , 1996, The Journal of experimental medicine.

[159]  F. Denizot,et al.  CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene. , 1993, Journal of immunology.

[160]  J. Dagorn,et al.  Messenger RNA sequence and expression of rat pancreatitis-associated protein, a lectin-related protein overexpressed during acute experimental pancreatitis. , 1991, The Journal of biological chemistry.

[161]  Jia Newcombe,et al.  Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosis. , 2008, The American journal of pathology.

[162]  K. Ley,et al.  IL-17A-producing neutrophil-regulatory Tn lymphocytes , 2006, Immunologic research.

[163]  R. Coffman,et al.  TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. , 1989, Annual review of immunology.