Structures of Human Cytochrome P-450 2E1
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[1] H Koga,et al. Uncoupling of the cytochrome P-450cam monooxygenase reaction by a single mutation, threonine-252 to alanine or valine: possible role of the hydroxy amino acid in oxygen activation. , 1989, Proceedings of the National Academy of Sciences of the United States of America.
[2] G. Murshudov,et al. Refinement of macromolecular structures by the maximum-likelihood method. , 1997, Acta crystallographica. Section D, Biological crystallography.
[3] A. Nanji,et al. Markedly enhanced cytochrome P450 2E1 induction and lipid peroxidation is associated with severe liver injury in fish oil-ethanol-fed rats. , 1994, Alcoholism, clinical and experimental research.
[4] R. Schnellmann,et al. Analysis of the cytotoxic properties of linoleic acid metabolites produced by renal and hepatic P450s. , 2000, Toxicology and applied pharmacology.
[5] P. Watkins,et al. Characterization of ethanol-inducible human liver N-nitrosodimethylamine demethylase. , 1986, Biochemistry.
[6] C. Lieber,et al. Purification and characterization of human liver cytochrome P-450-ALC. , 1987, Biochemical and biophysical research communications.
[7] C. Ioannides,et al. Sex differences in the diabetes-induced modulation of rat hepatic cytochrome P450 proteins. , 1993, Biochemical pharmacology.
[8] D. Koop. Hydroxylation of p-nitrophenol by rabbit ethanol-inducible cytochrome P-450 isozyme 3a. , 1986, Molecular pharmacology.
[9] J. Halpert,et al. Analysis of Differential Substrate Selectivities of CYP2B6 and CYP2E1 by Site-Directed Mutagenesis and Molecular Modeling , 2003, Journal of Pharmacology and Experimental Therapeutics.
[10] P. Evans,et al. Scaling and assessment of data quality. , 2006, Acta crystallographica. Section D, Biological crystallography.
[11] William M. Lee,et al. Acetaminophen‐induced acute liver failure: Results of a United States multicenter, prospective study , 2005, Hepatology.
[12] D. Koop,et al. Formation of 19(S)-, 19(R)-, and 18(R)-hydroxyeicosatetraenoic acids by alcohol-inducible cytochrome P450 2E1. , 1993, The Journal of biological chemistry.
[13] Eric F. Johnson,et al. Determinants of Cytochrome P450 2C8 Substrate Binding , 2008, Journal of Biological Chemistry.
[14] Jose Cosme,et al. Crystal Structures of Human Cytochrome P450 3A4 Bound to Metyrapone and Progesterone , 2004, Science.
[15] M. J. Coon,et al. Peroxo-iron and oxenoid-iron species as alternative oxygenating agents in cytochrome P450-catalyzed reactions: switching by threonine-302 to alanine mutagenesis of cytochrome P450 2B4. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[16] D. Goodlett,et al. Identification of the Interactions between Cytochrome P450 2E1 and Cytochrome b5 by Mass Spectrometry and Site-directed Mutagenesis* , 2006, Journal of Biological Chemistry.
[17] H. Yamazaki,et al. Roles of NADPH-P450 reductase and apo- and holo-cytochrome b5 on xenobiotic oxidations catalyzed by 12 recombinant human cytochrome P450s expressed in membranes of Escherichia coli. , 2002, Protein expression and purification.
[18] C. Lieber,et al. Induction of cytochrome P450IIE1 in the obese overfed rat. , 1991, Molecular pharmacology.
[19] G Vriend,et al. WHAT IF: a molecular modeling and drug design program. , 1990, Journal of molecular graphics.
[20] A. Das,et al. Redox potential control by drug binding to cytochrome P450 3A4. , 2007, Journal of the American Chemical Society.
[21] M. Ingelman-Sundberg,et al. Ethanol-, fasting-, and acetone-inducible cytochromes P-450 in rat liver: regulation and characteristics of enzymes belonging to the IIB and IIE gene subfamilies. , 1988, Biochemistry.
[22] Kevin Cowtan,et al. research papers Acta Crystallographica Section D Biological , 2005 .
[23] E. Kharasch,et al. Identification of the enzyme responsible for oxidative halothane metabolism: implications for prevention of halothane hepatitis , 1996, The Lancet.
[24] G J Kleywegt,et al. Detection, delineation, measurement and display of cavities in macromolecular structures. , 1994, Acta crystallographica. Section D, Biological crystallography.
[25] Randy J. Read,et al. Phaser crystallographic software , 2007, Journal of applied crystallography.
[26] A. Voragen,et al. Mode of action of xylogalacturonan hydrolase towards xylogalacturonan and xylogalacturonan oligosaccharides. , 2005, The Biochemical journal.
[27] J. Halpert,et al. A truncation of 2B subfamily cytochromes P450 yields increased expression levels, increased solubility, and decreased aggregation while retaining function. , 2001, Archives of biochemistry and biophysics.
[28] F. Guengerich,et al. Kinetics of Cytochrome P450 2E1-Catalyzed Oxidation of Ethanol to Acetic Acid via Acetaldehyde* , 1999, The Journal of Biological Chemistry.
[29] P. Beaune,et al. Hydroxylation of chlorzoxazone as a specific probe for human liver cytochrome P-450IIE1 , 1990 .
[30] M. Ingelman-Sundberg,et al. Genetic polymorphism of human CYP2E1: characterization of two variant alleles. , 1997, Molecular pharmacology.
[31] Alvin C Bronstein,et al. 2006 Annual Report of the American Association of Poison Control Centers' National Poison Data System (NPDS) , 2007, Clinical toxicology.
[32] M. Komori,et al. Different mechanisms of regioselection of fatty acid hydroxylation by laurate (omega-1)-hydroxylating P450s, P450 2C2 and P450 2E1. , 1994, Journal of Biochemistry (Tokyo).
[33] J. Thornton,et al. PROCHECK: a program to check the stereochemical quality of protein structures , 1993 .
[34] Xinxin Ding,et al. Human extrahepatic cytochromes P450: function in xenobiotic metabolism and tissue-selective chemical toxicity in the respiratory and gastrointestinal tracts. , 2003, Annual review of pharmacology and toxicology.
[35] K Henrick,et al. Electronic Reprint Biological Crystallography Secondary-structure Matching (ssm), a New Tool for Fast Protein Structure Alignment in Three Dimensions Biological Crystallography Secondary-structure Matching (ssm), a New Tool for Fast Protein Structure Alignment in Three Dimensions , 2022 .
[36] F. Guengerich,et al. Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects. , 1991, Chemical research in toxicology.
[37] D. Lewis,et al. Cytochromes P450 in the bioactivation of chemicals. , 2004, Current topics in medicinal chemistry.
[38] F. Guengerich,et al. Cytochrome P450 enzymes involved in acetaminophen activation by rat and human liver microsomes and their kinetics. , 1993, Chemical research in toxicology.
[39] H. Yamazaki,et al. Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians. , 1994, The Journal of pharmacology and experimental therapeutics.
[40] P. Ortiz de Montellano,et al. Active site topology of human cytochrome P450 2E1. , 1996, Chemical research in toxicology.
[41] C. Lieber,et al. Acetaminophen activation by human liver cytochromes P450IIE1 and P450IA2. , 1989, Archives of biochemistry and biophysics.
[42] T. Shimada,et al. Oxidation of toxic and carcinogenic chemicals by human cytochrome P-450 enzymes. , 1991, Chemical research in toxicology.
[43] F. Gonzalez,et al. Stabilization of cytochrome P450j messenger ribonucleic acid in the diabetic rat. , 1987, Molecular endocrinology.
[44] M. Komori,et al. Replacement of Thr-303 of P450 2E1 with serine modifies the regioselectivity of its fatty acid hydroxylase activity. , 1993, Journal of biochemistry.
[45] M. J. Coon,et al. Epoxidation of olefins by cytochrome P450: evidence from site-specific mutagenesis for hydroperoxo-iron as an electrophilic oxidant. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[46] D. Salazar,et al. Obesity as a risk factor for drug-induced organ injury. VI. Increased hepatic P450 concentration and microsomal ethanol oxidizing activity in the obese overfed rat. , 1988, Biochemical and biophysical research communications.
[47] P. Beaune,et al. Reverse transcriptase-PCR quantification of mRNA levels from cytochrome (CYP)1, CYP2 and CYP3 families in 22 different human tissues , 2007, Pharmacogenetics and genomics.
[48] Frank E. Blaney,et al. Crystal Structure of Human Cytochrome P450 2D6* , 2005, Journal of Biological Chemistry.
[49] I. de Waziers,et al. Detection and characterization of novel polymorphisms in the CYP2E1 gene. , 1998, Pharmacogenetics.
[50] T. Porter. The roles of cytochrome b5 in cytochrome P450 reactions , 2002, Journal of biochemical and molecular toxicology.
[51] W. Trager,et al. Oxidation of acetaminophen to its toxic quinone imine and nontoxic catechol metabolites by baculovirus-expressed and purified human cytochromes P450 2E1 and 2A6. , 1998, Chemical research in toxicology.
[52] A. Cederbaum,et al. CYP2E1 and oxidative liver injury by alcohol. , 2008, Free radical biology & medicine.
[53] A. P. Koley,et al. Conformational modulation of human cytochrome P450 2E1 by ethanol and other substrates: a CO flash photolysis study. , 2000, Biochemistry.
[54] R. Tukey,et al. Caffeine metabolism by human hepatic cytochromes P450: contributions of 1A2, 2E1 and 3A isoforms. , 1994, Biochemical pharmacology.
[55] Anna L. Blobaum,et al. Novel Reversible Inactivation of Cytochrome P450 2E1 T303A by tert-Butyl Acetylene: The Role of Threonine 303 in Proton Delivery to the Active Site of Cytochrome P450 2E1 , 2004, Journal of Pharmacology and Experimental Therapeutics.
[56] J. Morrow,et al. Development of Oxidative Stress by Cytochrome P450 Induction in Rodents Is Selective for Barbiturates and Related to Loss of Pyridine Nucleotide-dependent Protective Systems* , 2008, Journal of Biological Chemistry.
[57] Ryan M. Laddusaw,et al. CYP2E1 Substrate Inhibition , 2008, Journal of Biological Chemistry.
[58] R. Peter,et al. Baculovirus expression and purification of human and rat cytochrome P450 2E1. , 1996, Archives of biochemistry and biophysics.
[59] J. Salaün,et al. Requirement for omega and (omega;-1)-hydroxylations of fatty acids by human cytochromes P450 2E1 and 4A11. , 1999, Journal of lipid research.
[60] Nathan A. Baker,et al. Electrostatics of nanosystems: Application to microtubules and the ribosome , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[61] Jaroslav Koca,et al. CAVER: a new tool to explore routes from protein clefts, pockets and cavities , 2006, BMC Bioinformatics.
[62] T. Goosen,et al. Differential effects of naturally occurring isothiocyanates on the activities of cytochrome P450 2E1 and the mutant P450 2E1 T303A. , 2001, Archives of biochemistry and biophysics.
[63] F. Guengerich,et al. Oxidation Kinetics of Ethanol by Human Cytochrome P450 2E1 , 1997, The Journal of Biological Chemistry.
[64] M. J. Coon,et al. Ethanol oxidation and toxicity: role of alcohol P-450 oxygenase. , 1986, Alcoholism, clinical and experimental research.
[65] Eric F. Johnson,et al. The Structure of Human Microsomal Cytochrome P450 3A4 Determined by X-ray Crystallography to 2.05-Å Resolution* , 2004, Journal of Biological Chemistry.
[66] F. Guengerich,et al. Expression of modified human cytochrome P450 2E1 in Escherichia coli, purification, and spectral and catalytic properties. , 1994, Archives of biochemistry and biophysics.
[67] A G Leslie,et al. Biological Crystallography Integration of Macromolecular Diffraction Data , 2022 .