IL‐3 up‐regulates and activates human eosinophil CD32 and αMβ2 integrin causing degranulation

Eosinophils contribute to the pathogenesis of multiple diseases, including asthma. Treatment with antibodies targeting IL‐5 or IL‐5 receptor α reduces the frequency of asthma exacerbations. Eosinophil receptors for IL‐5 share a common ß‐chain with IL‐3 and GM‐CSF receptors. We recently reported that IL‐3 is more potent than IL‐5 or GM‐CSF in maintaining the ERK/p90S6K/RPS6 ribosome‐directed signaling pathway, leading to increased protein translation.

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