Death following colchicine poisoning.

A 45-year-old male was admitted to hospital after 2 to 3 days of vomiting, nausea, and diarrhea following an apparent overdose of colchicine tables. During hospitalization his white blood cell count fell dramatically. At death, 33 h following initial hospitalization, pleural effusion with bilateral bronchopneumonia was evident, together with numerous bacterial colonies and marked hypocellularity of bone marrow and reduced megakaryocytes, erythroid, and myeloid cells. The most striking histological findings were numerous metaphasic mitotic figures in gastric and small bowel epithelia. Colchicine was detected, confirmed by high pressure liquid chromatography with photodiode array detection, and quantitated in antemortem plasma collected 3.3 h following hospitalization and in postmortem blood and bile. Colchicine was not detected in liver, vitreous humor, or stomach contents.

[1]  L. Moreland,et al.  Colchicine and gout. , 1991, Arthritis and rheumatism.

[2]  L. Shaw,et al.  Colchicine poisoning: report of a fatal case with body fluid analysis by GC/MS and histopathologic examination of postmortem tissues. , 1991, Journal of analytical toxicology.

[3]  R. Koda,et al.  Determination of the antimitotic agents N-desacetylcolchicine, demecolcine and colchicine in serum and urine. , 1990, Journal of chromatography.

[4]  D. L. Anderson,et al.  Colchicine toxicity: a case report. , 1989, Veterinary and human toxicology.

[5]  A. Rankin,et al.  A Fatal Colchicine Overdose , 1986, Anaesthesia and intensive care.

[6]  M. Neuss,et al.  Long-term colchicine administration leading to colchicine toxicity and death. , 1986, Arthritis and rheumatism.

[7]  R. Frayha,et al.  Acute colchicine poisoning presenting as symptomatic hypocalcaemia. , 1984, British journal of rheumatology.

[8]  Z. Handzel,et al.  Effect of colchicine on immunoregulatory abnormalities in familial Mediterranean fever. , 1983, Clinical and experimental immunology.

[9]  W. Allender Colchicine poisoning as a mode of suicide. , 1982, Journal of forensic sciences.

[10]  J. Stapczynski,et al.  Colchicine overdose: report of two cases and review of the literature. , 1981, Annals of emergency medicine.

[11]  Y. Caplan,et al.  A fatal overdose with colchicine. , 1980, Journal of analytical toxicology.

[12]  P. Galdós,et al.  Colchicine overdose: An unusual origin of multiorgan failure , 1979, Critical care medicine.

[13]  M. J. Stewart,et al.  Estimation of colchicine in a poisoned patient by using high performance liquid chromatography. , 1979, Clinical toxicology.

[14]  Y. Liu,et al.  Marrow aplasia induced by colchicine. A case report. , 1978, Arthritis and rheumatism.

[15]  R. Rodvien,et al.  Colchicine toxicity: a multisystem disease. , 1977, Archives of internal medicine.

[16]  N. Ertel,et al.  Colchicine plasma levels. Implications as to pharmacology and mechanism of action. , 1970, The American journal of medicine.

[17]  J. Headington,et al.  COLCHICINE-INDUCED EPITHELIAL ATYPIA. , 1963, American journal of clinical pathology.

[18]  J. Macleod,et al.  Hypersensitivity to Colchicine , 1947, Annals of the rheumatic diseases.