Abstract The phytochemical investigation of the roots of Rhus trichocarpa led to this isolation of five new alkyl phloroglucinol derivatives, characterized as (Z)-15-hydroxy-1-(2,4,6-trihydroxyphenyl)-9-octadecen-1-one (named trichocarpol A, 1), (Z)-15-hydroxy-1-(2,6-dihydroxy-4-methoxyphenyl)-9-octadecen-1-one (named trichocarpol B, 2), (Z)-17-hydroxy-1-(2,4,6-trihydroxyphenyl)-9-octadecen-1-one (named trichocarpol C, 3), (Z)-18-hydroxy-1-(2,4,6-trihydroxyphenyl)-9-octadecen-1-one (named trichocarpol D, 4), and (9Z,12Z)-18-hydroxy-1-(2,4,6-trihydroxyphenyl)-9,12-octadecadien-1-one (named trichocarpol E, 5), together with a known compound, 4-(2,6-dihydroxy-4-methoxyphenyl)-4-oxobutanoic acid (6). In vitro cytotoxic activity of compounds 1–6 was evaluated in the human gastric adenocarcinoma AGS cell line and compounds 1–5 showed significant cytotoxicity. Our results indicate that R. trichocarpa, especially the alkyl phloroglucinol derivatives in it, is a good source of promising natural agents for the treatment of gastric cancer.
[1]
Joongku Lee,et al.
Isolation and identification of pentagalloylglucose with broad-spectrum antibacterial activity from Rhus trichocarpa Miquel
,
2010
.
[2]
C. Hametner,et al.
Gel-Phase 13C NMR Spectroscopy of Selected Solid Phase Systems
,
2007
.
[3]
R. Andriantsiferana,et al.
New cytotoxic alkyl phloroglucinols from Protorhus thouvenotii.
,
2004,
Planta medica.
[4]
임한나,et al.
Rhus Trichocarpa Suppresses IgE-mediated Allergic Response In Vitro and In Vivo
,
2013
.
[5]
박 종희.
한국약초도감 = Medicinal plants of Korea
,
2004
.