A small molecule screen in stem-cell-derived motor neurons identifies a kinase inhibitor as a candidate therapeutic for ALS.
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L. Rubin | B. Wainger | C. Woolf | Antonio Cerqueira | S. Gupta | L. Davidow | Kevin J. Kim | Anthony C Arvanites | K. Rosowski | Clifford J Woolf | Pamela A. Schein | Y. Yang | Lance S Davidow | Lee L Rubin | Antonio Cerqueira | Yin M Yang | Shailesh K Gupta | Kevin J Kim | Berit E Powers | Brian J Wainger | Hien D Ngo | Kathryn A Rosowski | Pamela A Schein | Courtney A Ackeifi | Brian J. Wainger | Berit E. Powers | Courtney Ackeifi | H. D. Ngo | Anthony C. Arvanites
[1] Kevin Kim,et al. A TALEN genome-editing system for generating human stem cell-based disease models. , 2013, Cell stem cell.
[2] Alexander Böcker,et al. Discovery of inhibitors of microglial neurotoxicity acting through multiple mechanisms using a stem-cell-based phenotypic assay. , 2012, Cell stem cell.
[3] B. Pettmann,et al. Olesoxime delays muscle denervation, astrogliosis, microglial activation and motoneuron death in an ALS mouse model , 2012, Neuropharmacology.
[4] Janel O. Johnson,et al. Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: a cross-sectional study , 2012, The Lancet Neurology.
[5] V. Gribkoff,et al. The effects of dexpramipexole (KNS-760704) in individuals with amyotrophic lateral sclerosis , 2011, Nature Medicine.
[6] Theonie Anastassiadis,et al. Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity , 2011, Nature Biotechnology.
[7] David Heckerman,et al. A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD , 2011, Neuron.
[8] L. Barbeito,et al. Phenotypically aberrant astrocytes that promote motoneuron damage in a model of inherited amyotrophic lateral sclerosis , 2011, Proceedings of the National Academy of Sciences.
[9] Kevin Eggan,et al. Conversion of mouse and human fibroblasts into functional spinal motor neurons. , 2011, Cell stem cell.
[10] J. Steen,et al. A screen for regulators of survival of motor neuron protein levels. , 2011, Nature chemical biology.
[11] J. Mendell,et al. Astrocytes from Familial and Sporadic ALS Patients are Toxic to Motor Neurons , 2011, Nature Biotechnology.
[12] A. Acevedo-Arozena,et al. SOD1 and TDP-43 animal models of amyotrophic lateral sclerosis: recent advances in understanding disease toward the development of clinical treatments , 2011, Mammalian Genome.
[13] S. Koh,et al. Brief Review of the Role of Glycogen Synthase Kinase-3β in Amyotrophic Lateral Sclerosis , 2011, Neurology research international.
[14] Hynek Wichterle,et al. A functionally characterized test set of human induced pluripotent stem cells , 2011, Nature Biotechnology.
[15] Andreas Wree,et al. Small molecule GSK-3 inhibitors increase neurogenesis of human neural progenitor cells , 2011, Neuroscience Letters.
[16] H. Durham,et al. Calpastatin reduces toxicity of SOD1G93A in a culture model of amyotrophic lateral sclerosis , 2010, Neuroreport.
[17] Eun-Mi Hur,et al. GSK3 signalling in neural development , 2010, Nature Reviews Neuroscience.
[18] R. Roos,et al. Mutant SOD1 knockdown in all cell types ameliorates disease in G85R SOD1 mice with a limited additional effect over knockdown restricted to motor neurons , 2010, Journal of neurochemistry.
[19] J. Grosskreutz,et al. Calcium dysregulation in amyotrophic lateral sclerosis. , 2010, Cell calcium.
[20] D. Cleveland,et al. Non–cell autonomous toxicity in neurodegenerative disorders: ALS and beyond , 2009, The Journal of cell biology.
[21] O. Hardiman,et al. Control of Motoneuron Survival by Angiogenin , 2008, The Journal of Neuroscience.
[22] F. Gage,et al. Non-cell-autonomous effect of human SOD1 G37R astrocytes on motor neurons derived from human embryonic stem cells. , 2008, Cell stem cell.
[23] K. Eggan,et al. Human embryonic stem cell-derived motor neurons are sensitive to the toxic effect of glial cells carrying an ALS-causing mutation. , 2008, Cell stem cell.
[24] V. Gribkoff,et al. KNS‐760704 [(6R)‐4,5,6,7‐tetrahydro‐N6‐propyl‐2, 6‐benzothiazole‐diamine dihydrochloride monohydrate] for the Treatment of Amyotrophic Lateral Sclerosis , 2008, CNS neuroscience & therapeutics.
[25] Murray Grossman,et al. TARDBP mutations in amyotrophic lateral sclerosis with TDP-43 neuropathology: a genetic and histopathological analysis , 2008, The Lancet Neurology.
[26] L. Rubin. Stem Cells and Drug Discovery: The Beginning of a New Era? , 2008, Cell.
[27] P. Cohen,et al. The selectivity of protein kinase inhibitors: a further update. , 2007, The Biochemical journal.
[28] W. Robberecht,et al. Vascular endothelial growth factor counteracts the loss of phospho‐Akt preceding motor neurone degeneration in amyotrophic lateral sclerosis , 2007, Neuropathology and applied neurobiology.
[29] C. Henderson,et al. Identification and Characterization of Cholest-4-en-3-one, Oxime (TRO19622), a Novel Drug Candidate for Amyotrophic Lateral Sclerosis , 2007, Journal of Pharmacology and Experimental Therapeutics.
[30] B. Doble,et al. Functional redundancy of GSK-3α and GSK-3β in wnt/β-catenin signaling shown by using an allelic series of embryonic stem cell lines , 2007 .
[31] Youngchul Kim,et al. Inhibition of glycogen synthase kinase-3 suppresses the onset of symptoms and disease progression of G93A-SOD1 mouse model of ALS , 2007, Experimental Neurology.
[32] Hynek Wichterle,et al. Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons , 2007, Nature Neuroscience.
[33] Kevin Eggan,et al. Non–cell autonomous effect of glia on motor neurons in an embryonic stem cell–based ALS model , 2007, Nature Neuroscience.
[34] H. Akiyama,et al. TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. , 2006, Biochemical and biophysical research communications.
[35] J. Crow,et al. The CB2 cannabinoid agonist AM‐1241 prolongs survival in a transgenic mouse model of amyotrophic lateral sclerosis when initiated at symptom onset , 2006, Journal of neurochemistry.
[36] Bruce L. Miller,et al. Ubiquitinated TDP-43 in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis , 2006, Science.
[37] D. Cleveland,et al. ALS: A Disease of Motor Neurons and Their Nonneuronal Neighbors , 2006, Neuron.
[38] A. Makriyannis,et al. AM1241, a cannabinoid CB2 receptor selective compound, delays disease progression in a mouse model of amyotrophic lateral sclerosis. , 2006, European journal of pharmacology.
[39] B. Monia,et al. Antisense oligonucleotide therapy for neurodegenerative disease. , 2006, The Journal of clinical investigation.
[40] S. Lorenzl,et al. The matrix metalloproteinases inhibitor Ro 26-2853 extends survival in transgenic ALS mice , 2006, Experimental Neurology.
[41] H. Wootz,et al. XIAP decreases caspase-12 cleavage and calpain activity in spinal cord of ALS transgenic mice. , 2006, Experimental cell research.
[42] R. Sandyk. SEROTONERGIC MECHANISMS IN AMYOTROPHIC LATERAL SCLEROSIS , 2006, The International journal of neuroscience.
[43] K. Taira,et al. Transgenic Small Interfering RNA Halts Amyotrophic Lateral Sclerosis in a Mouse Model* , 2005, Journal of Biological Chemistry.
[44] B. Pettmann,et al. Foxo3a induces motoneuron death through the Fas pathway in cooperation with JNK , 2004, BMC Neuroscience.
[45] S. Kim,et al. Epigallocatechin gallate prevents oxidative-stress-induced death of mutant Cu/Zn-superoxide dismutase (G93A) motoneuron cells by alteration of cell survival and death signals. , 2004, Toxicology.
[46] Hynek Wichterle,et al. Functional Properties of Motoneurons Derived from Mouse Embryonic Stem Cells , 2004, The Journal of Neuroscience.
[47] H. Wichterle,et al. Directed Differentiation of Embryonic Stem Cells into Motor Neurons , 2002, Cell.
[48] S. R. Datta,et al. Transcription-dependent and -independent control of neuronal survival by the PI3K–Akt signaling pathway , 2001, Current Opinion in Neurobiology.
[49] L. Martin,et al. Neuronal cell death in nervous system development, disease, and injury (Review). , 2001, International journal of molecular medicine.
[50] T. Tan,et al. A Novel Human STE20-related Protein Kinase, HGK, That Specifically Activates the c-Jun N-terminal Kinase Signaling Pathway* , 1999, The Journal of Biological Chemistry.
[51] L. Rubin,et al. Phosphorylation of c-Jun Is Necessary for Apoptosis Induced by Survival Signal Withdrawal in Cerebellar Granule Neurons , 1998, The Journal of Neuroscience.
[52] Robert H. Brown,et al. Amyotrophic lateral sclerosis. Insights from genetics. , 1997, Archives of neurology.
[53] L. Rubin,et al. A c-jun dominant negative mutant protects sympathetic neurons against programmed cell death , 1995, Neuron.
[54] A. Ludolph,et al. Amyotrophic lateral sclerosis. , 2012, Current opinion in neurology.
[55] I. Niebroj-Dobosz,et al. Matrix metalloproteinases and their tissue inhibitors in serum and cerebrospinal fluid of patients with amyotrophic lateral sclerosis. , 2010, European journal of neurology.
[56] B. Doble,et al. Functional redundancy of GSK-3alpha and GSK-3beta in Wnt/beta-catenin signaling shown by using an allelic series of embryonic stem cell lines. , 2007, Developmental cell.
[57] S. Lorenzl,et al. The matrix metalloproteinases inhibitor Ro 28-2653 [correction of Ro 26-2853] extends survival in transgenic ALS mice. , 2006, Experimental neurology.
[58] M. Mattson,et al. Anti-apoptotic actions of cycloheximide: blockade of programmed cell death or induction of programmed cell life? , 2004, Apoptosis.
[59] Ya-min Wu,et al. Directed differentiation of embryonic stem cells into motor neurons by gene , 2004 .
[60] R. Miller,et al. Riluzole for amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND). , 2003, Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases.
[61] Z. Xia,et al. Signaling pathways mediating anti-apoptotic action of neurotrophins. , 2000, Acta neurobiologiae experimentalis.
[62] Glycogen Synthase Kinase-3 (cid:1) Phosphorylates Bax and Promotes Its Mitochondrial Localization during Neuronal Apoptosis , 2022 .