Detection and functional portrayal of a novel class of dihydrotestosterone derived selective progesterone receptor modulators (SPRM)
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M. Baker | F. Frey | B. Frey | O. Mani | Thomas Andrieu | R. Bertolini | Raschid Setoud | Kayla Y. Uh | C. Goepfert | Andreas Guettinger | M. Baker
[1] M. Baker,et al. Evolution of hormone selectivity in glucocorticoid and mineralocorticoid receptors , 2013, The Journal of Steroid Biochemistry and Molecular Biology.
[2] D. Edwards,et al. Synthesis and antiprogestational properties of novel 17-fluorinated steroids , 2013, Steroids.
[3] Andres Forero,et al. Phase II Trial of Bicalutamide in Patients with Androgen Receptor–Positive, Estrogen Receptor–Negative Metastatic Breast Cancer , 2013, Clinical Cancer Research.
[4] M. Baker,et al. What are the physiological estrogens? , 2013, Steroids.
[5] M. Laufgraben,et al. Mifepristone for Management of Cushing's Syndrome , 2013, Pharmacotherapy.
[6] Sara E. Nichols,et al. A novel steroidal antiandrogen targeting wild type and mutant androgen receptors. , 2011, Biochemical pharmacology.
[7] C. Telleria,et al. Antiprogestin mifepristone inhibits the growth of cancer cells of reproductive and non-reproductive origin regardless of progesterone receptor expression , 2011, BMC Cancer.
[8] P. Bartůněk,et al. Two Panels of Steroid Receptor Luciferase Reporter Cell Lines for Compound Profiling , 2011, Combinatorial chemistry & high throughput screening.
[9] Vincent Laudet,et al. Origin and evolution of the ligand-binding ability of nuclear receptors , 2011, Molecular and Cellular Endocrinology.
[10] M. Baker,et al. 3D models of lamprey progesterone receptor complexed with progesterone, 7α-hydroxy-progesterone and 15α-hydroxy-progesterone , 2011, Steroids.
[11] D. Surbek,et al. Regulation of placental growth by aldosterone and cortisol. , 2010, Endocrinology.
[12] M. Kampa,et al. Testosterone membrane‐initiated action in breast cancer cells: Interaction with the androgen signaling pathway and EPOR , 2010, Molecular oncology.
[13] J. Fagart,et al. Met909 Plays a Key Role in the Activation of the Progesterone Receptor and Also in the High Potency of 13-Ethyl Progestins , 2009, Molecular Pharmacology.
[14] J. Uitdehaag,et al. The X-ray Structure of RU486 Bound to the Progesterone Receptor in a Destabilized Agonistic Conformation , 2009, The Journal of Biological Chemistry.
[15] A. Sommer,et al. Global gene expression profiling of progesterone receptor modulators in T47D cells provides a new classification system , 2009, The Journal of Steroid Biochemistry and Molecular Biology.
[16] G. Kallergi,et al. Membrane androgen receptor activation in prostate and breast tumor cells: Molecular signaling and clinical impact , 2009, IUBMB life.
[17] David Thompson,et al. Compound Profiling Using a Panel of Steroid Hormone Receptor Cell-Based Assays , 2008, Journal of biomolecular screening.
[18] R. Winneker,et al. A new generation of progesterone receptor modulators , 2008, Steroids.
[19] C. Clarke,et al. Antiproliferative actions of the synthetic androgen, mibolerone, in breast cancer cells are mediated by both androgen and progesterone receptors , 2008, The Journal of Steroid Biochemistry and Molecular Biology.
[20] B. Allolio,et al. Mifepristone (RU 486) in Cushing's syndrome. , 2007, European journal of endocrinology.
[21] Shawn P Williams,et al. A structural and in vitro characterization of asoprisnil: a selective progesterone receptor modulator. , 2007, Molecular endocrinology.
[22] Takashi Suzuki,et al. 5α‐Reductase type 1 and aromatase in breast carcinoma as regulators of in situ androgen production , 2007, International journal of cancer.
[23] Kanyawim Kirtikara,et al. Sulforhodamine B colorimetric assay for cytotoxicity screening , 2006, Nature Protocols.
[24] R. Sitruk-Ware. Mifepristone and misoprostol sequential regimen side effects, complications and safety. , 2006, Contraception.
[25] C. Russell,et al. Long-Term Administration of Mifepristone (RU486): Clinical Tolerance During Extended Treatment of Meningioma , 2006, Cancer investigation.
[26] Timothy M Willson,et al. A Ligand-mediated Hydrogen Bond Network Required for the Activation of the Mineralocorticoid Receptor*[boxs] , 2005, Journal of Biological Chemistry.
[27] J. Cidlowski,et al. The Origin and Functions of Multiple Human Glucocorticoid Receptor Isoforms , 2004, Annals of the New York Academy of Sciences.
[28] M. Baker,et al. Co-evolution of steroidogenic and steroid-inactivating enzymes and adrenal and sex steroid receptors , 2004, Molecular and Cellular Endocrinology.
[29] R. Steiner,et al. A novel, high-affinity, fluorescent progesterone receptor antagonist. Synthesis and in vitro studies. , 2004, Bioconjugate chemistry.
[30] I. Spitz. Progesterone antagonists and progesterone receptor modulators: an overview , 2003, Steroids.
[31] M. Bergström,et al. Effects of androgens on aromatase activity and 11C‐vorozole binding in granulosa cells in vitro , 2003, Acta obstetricia et gynecologica Scandinavica.
[32] C. Stournaras,et al. The human prostate cancer cell line LNCaP bears functional membrane testosterone receptors, which increase PSA secretion and modify actin cytoskeleton , 2002, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[33] T. Willson,et al. Crystal Structure of the Glucocorticoid Receptor Ligand Binding Domain Reveals a Novel Mode of Receptor Dimerization and Coactivator Recognition , 2002, Cell.
[34] Howard M. Einspahr,et al. Crystallographic structures of the ligand-binding domains of the androgen receptor and its T877A mutant complexed with the natural agonist dihydrotestosterone , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[35] J. Foekens,et al. Progesterone antagonists and progesterone receptor modulators in the treatment of breast cancer , 2000, Steroids.
[36] W. Schoonen,et al. Influence of the substitution of 11-methylene, Δ15, and/or 18-methyl groups in norethisterone on receptor binding, transactivation assays and biological activities in animals , 2000, The Journal of Steroid Biochemistry and Molecular Biology.
[37] Peter Scholz,et al. Structural Evidence for Ligand Specificity in the Binding Domain of the Human Androgen Receptor , 2000, The Journal of Biological Chemistry.
[38] C. Hellal-Levy,et al. Mechanistic aspects of mineralocorticoid receptor activation. , 2000, Kidney international.
[39] J. Dhainaut,et al. Effects of dobutamine on gastric mucosal perfusion and hepatic metabolism in patients with septic shock. , 1999, American journal of respiratory and critical care medicine.
[40] P. Sigler,et al. Atomic structure of progesterone complexed with its receptor , 1998, Nature.
[41] E. Gurpide,et al. Estrogenic and progestagenic activities of physiologic and synthetic androgens, as measured by in vitro bioassays. , 1997, Methods and findings in experimental and clinical pharmacology.
[42] G. Teutsch,et al. Non-steroidal antiandrogens: Synthesis and biological profile of high-affinity ligands for the androgen receptor , 1994, The Journal of Steroid Biochemistry and Molecular Biology.
[43] O. Jänne,et al. A single-base substitution in exon 6 of the androgen receptor gene causing complete androgen insensitivity: the mutated receptor fails to transactivate but binds to DNA in vitro. , 1993, Human molecular genetics.
[44] V. Jordan,et al. Estrogenic actions of RU486 in hormone-responsive MCF-7 human breast cancer cells , 1993 .
[45] P. Chambon,et al. Progestin receptors: Isoforms and antihormone action , 1991, The Journal of Steroid Biochemistry and Molecular Biology.
[46] A. Albertini,et al. Progestin regulation of alkaline phosphatase in the human breast cancer cell line T47D. , 1991, Cancer research.
[47] E. Baulieu. Contragestion and other clinical applications of RU 486, an antiprogesterone at the receptor , 1989 .
[48] P. Munson,et al. The antiglucocorticoid and antiprogestin steroid RU 486 suppresses the adrenocorticotropin response to ovine corticotropin releasing hormone in man. , 1988, The Journal of clinical endocrinology and metabolism.
[49] B. Sun,et al. Modulation of aromatase activity in human endometrial stromal cells by steroids, tamoxifen and RU 486. , 1986, Endocrinology.
[50] D. Philibert,et al. RU 38486: a potent antiglucocorticoid in vitro and in vivo. , 1985, Journal of steroid biochemistry.
[51] G. Chrousos,et al. Successful treatment of Cushing's syndrome with the glucocorticoid antagonist RU 486. , 1985, The Journal of clinical endocrinology and metabolism.
[52] L C Murphy,et al. Differential sensitivity of human breast cancer cell lines to the growth-inhibitory effects of tamoxifen. , 1985, Cancer research.
[53] K. Pearce,et al. Structure and function of the glucocorticoid receptor ligand binding domain. , 2004, Vitamins and hormones.
[54] E. Gelmann,et al. Antiandrogen effects of mifepristone on coactivator and corepressor interactions with the androgen receptor. , 2004, Molecular endocrinology.
[55] B. Katzenellenbogen,et al. Novel ligands that function as selective estrogens or antiestrogens for estrogen receptor-alpha or estrogen receptor-beta. , 1999, Endocrinology.