Reduced CT iodine perfusion score is associated with adverse clinical outcomes in acute pulmonary embolism

on Force scanners (Siemens Healthineers, Forchheim, Germany) using CareDose in dual energy mode. The dual energy image volume pairs were loaded into a prototype, Dual Energy Lung Isolation, on the eXamine platform (Siemens Healthineers) for analysis. This prototype automatically determines the lobular boundaries using a generative machine learning technique and com-putes the concentration of iodine in the lungs using a material decomposition technique. 4,5,8 On a per lobe and per lung basis, the prototype reports the overall volume (mL), amount of iodine (mg), and the iodine concentration (mg/mL). For the purpose of this analysis, the whole-lung mean concentration (mg/mL) was reported. Patient characteristics were summarized using descriptive statistics. Data were pre-sented as median with SD, mediate with IQR, or number ( n ) with percentage (%). Data were analyzed using Wilcoxon rank-sum, Pearson’s chi-squared, and Fisher’s exact tests, as appropriate. We performed a multivariable logistic regres-sion analysis to determine the association between the primary outcome with the iodine score. Confounders included in the model were selected based on clinical plausibility and included age, sex, history of cardiopulmonary disease, and history of cancer.