Anticonvulsive effects of intracerebroventricular administration of rutin in rats

[1]  D. Jiang,et al.  Inhibitory effect of Erigeron breviscapus extract and its flavonoid components on GABA shunt enzymes. , 2008, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[2]  H. Sadeghnia,et al.  Protective effect of safranal on pentylenetetrazol-induced seizures in the rat: involvement of GABAergic and opioids systems. , 2007, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[3]  D. Newman,et al.  Natural products as sources of new drugs over the last 25 years. , 2007, Journal of natural products.

[4]  Z. Vujic,et al.  Isocratic RP-HPLC method for rutin determination in solid oral dosage forms. , 2007, Journal of pharmaceutical and biomedical analysis.

[5]  C. Roussos,et al.  Enzymatic esterification of flavonoids with unsaturated fatty acids: Effect of the novel esters on vascular endothelial growth factor release from K562 cells , 2006 .

[6]  K. Shiwaku,et al.  Antioxidant flavonol glycosides in mulberry (Morus alba L.) leaves isolated based on LDL antioxidant activity , 2006 .

[7]  H. Gruber,et al.  Combined enzymatic and antioxidative treatment reduces ischemia-reperfusion injury in rabbit skeletal muscle. , 2006, The Journal of surgical research.

[8]  Sebastian P Fernandez,et al.  Central nervous system depressant action of flavonoid glycosides. , 2006, European journal of pharmacology.

[9]  J. Bernatonienė,et al.  The effect of flavonoids on rat heart mitochondrial function. , 2006, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[10]  N. Sucher,et al.  Insights from molecular investigations of traditional Chinese herbal stroke medicines: Implications for neuroprotective epilepsy therapy , 2006, Epilepsy & Behavior.

[11]  H. Xue,et al.  Neuroactive flavonoids interacting with GABAA receptor complex. , 2005, Current drug targets. CNS and neurological disorders.

[12]  H. Hosseinzadeh,et al.  Intracerebroventricular administration of thymoquinone, the major constituent of Nigella sativa seeds, suppresses epileptic seizures in rats. , 2005, Medical science monitor : international medical journal of experimental and clinical research.

[13]  F. Koehn,et al.  The evolving role of natural products in drug discovery , 2005, Nature Reviews Drug Discovery.

[14]  H. Hosseinzadeh,et al.  The effects of carbenoxolone on spatial learning in the Morris water maze task in rats. , 2005, Medical science monitor : international medical journal of experimental and clinical research.

[15]  J. Sheu,et al.  Mechanisms involved in the antiplatelet activity of rutin, a glycoside of the flavonol quercetin, in human platelets. , 2004, Journal of agricultural and food chemistry.

[16]  A. Bast,et al.  Sustained protective effects of 7-monohydroxyethylrutoside in an in vivo model of cardiac ischemia-reperfusion. , 2004, European journal of pharmacology.

[17]  H. Xue,et al.  Development of effective therapeutics targeting the GABAA receptor: naturally occurring alternatives. , 2004, Current pharmaceutical design.

[18]  C. Sánchez,et al.  Anticonvulsant and antiepileptogenic effects of GABAA receptor ligands in pentylenetetrazole-kindled mice , 2004, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[19]  Manjeet Singh,et al.  Neuroprotective effect of antioxidants on ischaemia and reperfusion-induced cerebral injury. , 2003, Pharmacological research.

[20]  J. Medina,et al.  6-Methylapigenin and hesperidin: new valeriana flavonoids with activity on the CNS , 2003, Pharmacology Biochemistry and Behavior.

[21]  Josemir W Sander.  The epidemiology of epilepsy revisited , 2003, Current opinion in neurology.

[22]  S. Sombati,et al.  Anticonvulsant effect of FS‐1 subfraction isolated from roots of Delphinim denudatum on hippocampal pyramidal neurons , 2003, Phytotherapy research : PTR.

[23]  A. Gilani,et al.  Protective effect of rutin on paracetamol- and CCl4-induced hepatotoxicity in rodents. , 2002, Fitoterapia.

[24]  J. Medina,et al.  Isolation and identification of 6-methylapigenin, a competitive ligand for the brain GABA(A) receptors, from Valeriana wallichii. , 2002, Planta medica.

[25]  T. Liljefors,et al.  Refinement and evaluation of a pharmacophore model for flavone derivatives binding to the benzodiazepine site of the GABA(A) receptor. , 2002, Journal of medicinal chemistry.

[26]  A. Paladini,et al.  GABA(A)-receptor ligands of flavonoid structure. , 2002, Current topics in medicinal chemistry.

[27]  R. Neviere,et al.  Beneficial effects of different flavonoids, on functional recovery after ischemia and reperfusion in isolated rat heart. , 2001, Bioorganic & medicinal chemistry letters.

[28]  Josemir W Sander,et al.  Patients’ perspectives on services for epilepsy: a survey of patient satisfaction, preferences and information provision in 2394 people with epilepsy , 2000, Seizure.

[29]  M. Baraldi,et al.  Behavioral characterisation of the flavonoids apigenin and chrysin. , 2000, Fitoterapia.

[30]  V. Motilva,et al.  Evidence for protective and antioxidant properties of rutin, a natural flavone, against ethanol induced gastric lesions. , 2000, Journal of ethnopharmacology.

[31]  C. Lau,et al.  Review on phytotherapy in epilepsy , 2000, Seizure.

[32]  J. Medina,et al.  6-Chloro-3′-nitroflavone is a Potent Ligand for the Benzodiazepine Binding Site of the GABAA Receptor Devoid of Intrinsic Activity , 2000, Pharmacology Biochemistry and Behavior.

[33]  J. Medina,et al.  Flavonoids and the Central Nervous System: from Forgotten Factors to Potent Anxiolytic Compounds , 1999, The Journal of pharmacy and pharmacology.

[34]  A. Ropper,et al.  Adams and Victor's Principles of Neurology , 1997 .

[35]  J. Medina,et al.  Overview—Flavonoids: A New Family of Benzodiazepine Receptor Ligands , 1997, Neurochemical Research.

[36]  H. Sejima,et al.  Regional excitatory and inhibitory amino acid concentrations in pentylenetetrazol kindling and kindled rat brain , 1997, Brain and Development.

[37]  W. Löscher,et al.  The role of technical, biological and pharmacological factors in the laboratory evaluation of anticonvulsant drugs. III. Pentylenetetrazole seizure models , 1991, Epilepsy Research.

[38]  J H Medina,et al.  Chrysin (5,7-di-OH-flavone), a naturally-occurring ligand for benzodiazepine receptors, with anticonvulsant properties. , 1990, Biochemical pharmacology.

[39]  Marjan Nassiri-Asl,et al.  Bmc Complementary and Alternative Medicine Anticonvulsant Effects of Aerial Parts of Passiflora Incarnata Extract in Mice: Involvement of Benzodiazepine and Opioid Receptors , 2007 .

[40]  S. File,et al.  Intrinsic actions of the benzodiazepine receptor antagonist Ro 15-1788 , 2004, Psychopharmacology.

[41]  E. Schwedhelm,et al.  Clinical Pharmacokinetics of Antioxidants and Their Impact on Systemic Oxidative Stress , 2003, Clinical pharmacokinetics.

[42]  G. Paxinos,et al.  The Rat Brain in Stereotaxic Coordinates , 1983 .