The intervention effect of Schisandra polysaccharide on hepatoma mice serum IL-6, TNF-α and VEGF expression

Objective To study the intervention effect of Schisandra polysaccharide on hepatoma mice serum immune related cytokines of IL-6,TNF-α and VEGF expression.Methods One hundred mice were randomly divided into normal control group of 50 cases (without application of Schisandra polysaccharides),50 cases of digestive tract tumor in observation group (receiving Schisandra polysaccharide for one week).Blood was sampled from two groups after 1 week,serum IL-6,TNF-α,VEGF expression level were detected by ELISA.Results The IL-6,TNF-α and VEGF expression levels before experiment in the two groups had no significant difference(t =3.12,3.22,2.45,P > 0.05).But there were significant differences in IL-6,TNF-α,VEGF expression levels between the two groups (t =15.09,21.34,19.21,P <0.05).Conclusions The expression levels of serum IL-6,TNF-α and VEGF in hepatoma mice are influenced by Schisandra polysaccharide,and it can become hepatoma treatment drug. Key words: Schisandra polysaccharide ;  Interleukin-6 ;  Tumor necrosis factor-α ;  Vascular endothelial growth factor