ROLE OF ENZYMATIC ACTIVATION AND INACTIVATION IN DRUG SELECTIVITY
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[1] M. Esterman,et al. Metabolism and biochemistry of mycophenolic acid. , 1972, Cancer research.
[2] N. Sládek. Therapeutic efficacy of cyclophosphamide as a function of inhibition of its metabolism. , 1972, Cancer research.
[3] D. Hill,et al. Enzymatic metabolism of cyclophosphamide and nicotine and production of a toxic cyclophosphamide metabolite. , 1972, Cancer research.
[4] H. Borberg,et al. Characterization of protein and DNA in P815 cells sensitive and resistant to 1- -D-arabinofuranosylcytosine. , 1972, Cancer research.
[5] N. Sládek. Therapeutic efficacy of cyclophosphamide as a function of its metabolism. , 1972, Cancer research.
[6] A. Sartorelli,et al. Studies of the antineoplastic activity and metabolism of -(N)-heterocyclic carboxaldehyde thiosemicarbazones in dogs and mice. , 1972, Cancer research.
[7] N. Bachur,et al. Daunorubicin metabolism by human hematological components. , 1972, Cancer research.
[8] J. Brown,et al. The role of phosphohydrolases in the mechanism of resistance of neoplastic cells to 6-thiopurines. , 1971, Cancer research.
[9] C. D. Steuart,et al. Cytidine deaminase and the development of resistance to arabinosyl cytosine. , 1971, Nature: New biology.
[10] R. Adamson. METABOLISM OF ANTICANCER AGENTS IN MAN , 1971, Annals of the New York Academy of Sciences.
[11] N. Bachur,et al. Daunorubicin metabolism by rat tissue preparations. , 1971, The Journal of pharmacology and experimental therapeutics.
[12] N. Bachur. Daunorubicinol, a major metabolite of daunorubicin: isolation from human urine and enzymatic reactions. , 1971, The Journal of pharmacology and experimental therapeutics.
[13] N. Sládek. Metabolism of cyclophosphamide by rat hepatic microsomes. , 1971, Cancer research.
[14] M. J. Sweeney,et al. Possible in Situ Activation of Mycophenolic Acid by β-Glucuronidase , 1971 .
[15] N. Bachur,et al. Daunomycin metabolism in rat tissue slices. , 1970, The Journal of pharmacology and experimental therapeutics.
[16] A. S. Gordon,et al. Nucleoside deaminase: an enzymatic marker for stress erythropoiesis in the mouse. , 1970, The Journal of clinical investigation.
[17] F. Šorm,et al. Association of decreased uridine and deoxycytidine kinase with enhanced RNA and DNA polymerase in mouse leukemic cells resistant to 5-azacytidine and 5-aza-2'-deoxycytidine. , 1970, Cancer research.
[18] J L Cohen,et al. Enzymatic basis of cyclophosphamide activation by hepatic microsomes of the rat. , 1970, The Journal of pharmacology and experimental therapeutics.
[19] G. Bryan,et al. Metabolism of 4(5)-(3,3-dimethyl-1-triazeno)-imidazole-5(4)-carboxamide to 4(5)-aminoimidazole-5(4)-carboxamide in man. , 1970, Biochemical pharmacology.
[20] J Morrow,et al. Genetic analysis of azaguanine resistance in an established mouse cell line. , 1970, Genetics.
[21] M. Colvin,et al. The enzymatic reduction of hydroxyurea to urea by mouse liver. , 1970, Cancer research.
[22] J. Hadfield,et al. The binding of vinblastine by platelets in the rat. , 1970, Cancer research.
[23] R. Adamson,et al. The absorption, distribution, excretion, and biotransformation of the carcinostatic 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea in animals. , 1970, Cancer research.
[24] A. Schrecker. Metabolism of 1-beta-D-arabinofuranosylcytosine in leukemia L1210: nucleoside and nucleotide kinases in cell-free extracts. , 1970, Cancer research.
[25] D. Kessel,et al. Retention of 6-mercaptopurine derivatives by intact cells as an index of drug response in human and murine leukemias. , 1969, Cancer research.
[26] P. Reyes,et al. Synthesis of 5-fluorouridine 5'-phosphate by a pyrimidine phosphoribosyltransferase of mammalian origin. II. Correlation between the tumor levels of the enzyme and the 5-fluorouracil-promoted increase in survival of tumor-bearing mice. , 1969, Biochemical pharmacology.
[27] B. Dewald,et al. N-demethylation of p-(N1-methylhydrazion methyl)-N-isopropyl benzamide (procarbazine), a cytostatically active methylhydrazine derivative, in the intact rat and in the isolated perfused rat liver. , 1969, Biochemical pharmacology.
[28] B. Dewald,et al. Oxidation of p-(N1-methylhydrazino methyl)-N-isopropyl benzamide (procarbazine) to the methylazo derivative and oxidative cleavage of the N2-C bond in the isolated perfused rat liver. , 1969, Biochemical pharmacology.
[29] Yamamoto Itaru. 4 (or 5)-diazoimidazole-5 (or 4)-carboxamide and related triazenoimidazoles as antibacterial agents: their effects on nucleic acid metabolism of Escherichia coli B. , 1969 .
[30] T. L. Loo,et al. Elevated inary excretion of 4-aminoimidazole-5-carboxamide in patients after intravenous injection of 4-(3,3-dimethyl-1-triazeno)imidazole-5-carboxamide. , 1969, Life sciences.
[31] T. Krenitsky. Tissue distribution of purine ribosyl- and phosphoribosyltransferases in the Rhesus monkey. , 1969, Biochimica et biophysica acta.
[32] D. Smithers,et al. Resistance to 4-aminopyrazolo (3,4-d) pyrimidine. , 1969, Biochemical pharmacology.
[33] G. Lepage,et al. Nucleotide Formation from α- and β-2′-Deoxythioguanosine in Extracts of Murine and Human Tissues , 1969 .
[34] D. Rosenthal,et al. Uptake and phosphorylation of cytosine arabinoside by normal and leukemic human blood cells in vitro. , 1969, Cancer research.
[35] S. Gartler,et al. Development of a nonselective technique for studying 2, 6, diaminopurine resistance in an established murine cell line. , 1968, Genetics.
[36] E. Frei,et al. Distribution of purine ribonucleoside kinase and selective toxicity of 6-methyl thiopurine ribonucleoside. , 1968, Biochemical pharmacology.
[37] R. Koshiura,et al. Some Inhibitors of Deamination of 9-β-d-Arabinofuranosyladenine and 9-β-d-Xylofuranosyladenine by Blood and Neoplasms of Experimental Animals and Humans , 1968 .
[38] R. Dixon. Effect of Chloramphenicol on the Metabolism and Lethality of Cyclophosphamide in Rats∗ , 1968, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.
[39] E. Frei,et al. Clinical pharmacologic observations on 6‐mercaptopurine and 6‐methylthiopurine ribonucleoside , 1968, Clinical pharmacology and therapeutics.
[40] C. T. Beer,et al. The preparation of vinblastine-4-acetyl-t and its distribution in the blood of rats. , 1968, Journal of medicinal chemistry.
[41] J. Seegmiller,et al. Inherited disorder of purine metabolism. Correlation between central nervous system dysfunction and biochemical defects. , 1967, JAMA.
[42] A. Paterson,et al. Decreased feedback inhibition in a 6-(methylmercapto)purine ribonucleoside-resistant tumor. , 1967, Cancer research.
[43] B. Kennedy,et al. Studies with tritiated mithramycin in C3H mice. , 1967, Cancer research.
[44] C. G. Smith,et al. Studies of the enzymatic deamination of cytosine arabinoside. I. Enzyme distribution and species specificity. , 1967, Biochemical pharmacology.
[45] J. G. Simpson,et al. Studies of the Mode of Action of N-Isopropyl-α-(2-methylhydrazino)-p-toluamide , 1967 .
[46] I. Wodinsky,et al. Transport and Phosphorylation as Factors in the Antitumor Action of Cytosine Arabinoside , 1967, Science.
[47] J. F. Henderson,et al. Resistance to purine ribonucleoside analogues in an ascites tumor. , 1967, Canadian journal of biochemistry.
[48] I. Wodinsky,et al. Nucleotide Formation as a Determinant of 5-Fluorouracil Response in Mouse Leukemias , 1966, Science.
[49] J. Montgomery,et al. Activity of adenos1ne analogs against a cell culture, line resistant to 2-fluoroadenine , 1966 .
[50] H. Weissbach,et al. Studies on the disposition of actinomycin D-3H in virus-infected and tumor-bearing mice. , 1966, Cancer research.
[51] A. W. Murray. Purine-phosphoribosyltransferase activities in rat and mouse tissues and in Ehrlich ascites-tumour cells. , 1966, The Biochemical journal.
[52] T. A. Connors,et al. Cure of Mice bearing Advanced Plasma Cell Tumours with Aniline Mustard : the Relationship between Glucuronidase Activity and Tumour Sensitivity , 1966, Nature.
[53] A. Seligman,et al. Enzyme-alterable alkylating agents. IX. The enzymatic transformation of some nitrogen mustards in the presence of carbon dioxide: implications in respiration. , 1966, Cancer research.
[54] D. Blair,et al. The metabolism of 2,6-diaminopurine by diaminopurine-sensitive and diaminopurine-resistant L-strain mouse fibroblasts. , 1965, Canadian journal of biochemistry.
[55] R. Adamson,et al. The distribution, excretion and metabolism of hydroxyurea-C14. , 1965, The Journal of pharmacology and experimental therapeutics.
[56] E. Henderson,et al. The metabolic fate of tritiated methotrexate. I. Absorption, excretion, and distribution in mice, rats, dogs and monkeys. , 1965, Cancer research.
[57] E. Henderson,et al. The metabolic fate of tritiated methotrexate. II. Absorption and excretion in man. , 1965, Cancer research.
[58] R. Adamson,et al. The metabolite of 3', 5'-dichloro-4-amino-4-deoxy-N10-methylpteroylglutamic acid (dichloromethotrexate). , 1965, Journal of medicinal chemistry.
[59] V. Oliverio,et al. The physiologic disposition of dichloromethotrexate‐CI36 in man , 1965, Clinical pharmacology and therapeutics.
[60] V. Potter,et al. PYRIMIDINE METABOLISM IN TISSUE CULTURE CELLS DERIVED FROM RAT HEPATOMAS. I. SUSPENSION CELL CULTURES DERIVED FROM THE NOVIKOFF HEPATOMA. , 1965, Cancer research.
[61] A. Sartorelli,et al. THE METABOLISM OF THIOGUANINE IN PURINE ANALOG-RESISTANT CELLS. , 1964, Cancer research.
[62] J. Brink,et al. METABOLISM AND DISTRIBUTION OF 9-BETA-D-ARABINOFURANOSYLADENINE IN MOUSE TISSUES. , 1964, Cancer research.
[63] G. Lepage,et al. BIOCHEMICAL AND CARCINOSTATIC EFFECTS OF 2'-DEOXYTHIOGUANOSINE. , 1964, Cancer research.
[64] J. Brink,et al. METABOLIC EFFECTS OF 9-D-ARABINOSYLPURINES IN ASCITES TUMOR CELLS. , 1964, Cancer research.
[65] A. Sartorelli,et al. THE BIOCHEMICAL BASIS FOR THE DIFFERENTIAL SENSITIVITY OF INTESTINAL MUCOSA AND BONE MARROW TO 6-THIOGUANINE. , 1963, Cancer research.
[66] C. Heidelberger,et al. EXPERIMENTAL AND CLINICAL USE OF FLUORINATED PYRIMIDINES IN CANCER CHEMOTHERAPY. , 1963, Cancer research.
[67] G. P. Warwick. THE MECHANISM OF ACTION OF ALKYLATING AGENTS. , 1963, Cancer research.
[68] G. Hitchings,et al. RELATIONSHIP BETWEEN METABOLIC FATES AND ANTITUMOR ACTIVITIES OF THIOPURINES. , 1963, Cancer research.
[69] D. R. Dubbs,et al. DELETION OF THYMIDINE KINASE ACTIVITY FROM L CELLS RESISTANT TO BROMODEOXYURIDINE. , 1963, Experimental cell research.
[70] E. Henderson,et al. THE DISTRIBUTION, EXCRETION, AND METABOLISM OF METHYLGLYOXAL-BIS-GUANYLHYDRAZONE-C14. , 1963, The Journal of pharmacology and experimental therapeutics.
[71] C. Heidelberger,et al. STUDIES OF FLUORINATED PYRIMIDINES. XVIII. THE DEGRADATION OF 5-FLUORO-2'-DEOXYURIDINE AND RELATED COMPOUNDS BY NUCLEOSIDE PHOSPHORYLASE. , 1963, Biochemistry.
[72] D. B. Ellis,et al. Biochemical Studies of Resistance to 6-Thioguanine , 1963 .
[73] R. W. Brockman,et al. A biochemical basis for resistance of L1210 mouse leukemia to 6-thioguanine. , 1963, Biochemical pharmacology.
[74] L. Révész,et al. Studies on resistance against 5-fluorouracil. III. Selective value of resistant, uridine kinase-deficient tumor cells. , 1962, Cancer research.
[75] J. Montgomery,et al. Antitumor activity of triazenoimidazoles. , 1962, Biochemical pharmacology.
[76] P. K. Smith,et al. The metabolism of 1-aminocyclopentane-1-carboxylic acid in normal and neoplastic tissues. , 1962, Biochemical pharmacology.
[77] M. Jones,et al. Further studies on the mechanism of action of 6-thioguanine. , 1961, Cancer research.
[78] J. Wyngaarden,et al. 6-Mercaptopurine as substrate and inhibitor of xanthine oxidase , 1961 .
[79] R. W. Brockman. A mechanism of resistance to 6-mercaptopurine: metabolism of hypoxanthine and 6-mercaptopurine by sensitive and resistant neoplasms. , 1960, Cancer research.
[80] G. Lepage. Incorporation of 6-thioguanine into nucleic acids. , 1960, Cancer research.
[81] C. Heidelberger,et al. Studies on fluorinated pyrimidines. IX. The degradation of 5-fluorouracil-6-C14. , 1960, The Journal of biological chemistry.
[82] J. Davidson. Studies on the mechanism of action of 6-mercaptopurine in sensitive and resistant L1210 leukemia in vitro. , 1960, Cancer research.
[83] H. Skipper,et al. A mechanism of resistance to 8-azaguanine. II. Studies with experimental neoplasms. , 1959, Cancer research.
[84] G. Klein,et al. Possible Enzymic Mechanism for the Development of Resistance against Fluorouracil in Ascites Tumours , 1959, Nature.
[85] A. Sartorelli,et al. Metabolic effects of 6-thioguanine. I. Studies on thioguanine-resistant and-sensitive Ehrlich ascites cells. , 1958, Cancer research.
[86] E. C. Moore,et al. The metabolism of 6-thioguanine in normal and neoplastic tissues. , 1958, Cancer research.
[87] E. Trams,et al. Studies on the N-dealkylation of nitrogen mustard and triethylenemelamine by liver homogenates. , 1956, Cancer research.
[88] E. Trams,et al. Distribution of radiocarbon in liver chlorine, creatine, and methionine after the injection of methyl-C14-bis (beta-chloroethyl) amine. , 1955, Cancer research.
[89] A. Gellhorn,et al. Laboratory and clinical studies on 8‐azaguanine , 1953, Cancer.
[90] J. Kream,et al. Enzymatic deamination of 8-azaguanine in normal and neoplastic tissues. , 1952, Cancer research.
[91] W. Kreis. Metabolism of an antineoplastic methylhydrazine derivative in a P815 mouse neoplasm. , 1970, Cancer research.
[92] G. Lepage. Alterations in enzyme activity in tumors and the implications for chemotherapy. , 1970, Advances in enzyme regulation.
[93] M. Burch,et al. Studies on the uptake of tubeidin (7-deazaadenosine) by blood cells and its distribution in whole animals. , 1970, Cancer research.
[94] G. Bryan,et al. N-demethylation the antineoplastic agent4(5)-(3,3-dimethyl-1-triazeno)imidazole-5(4)-carboxamide by rats and man. , 1970, Cancer research.
[95] G. Lepage,et al. METABOLISM OF PURINE NUCLEOSIDE ANALOGS. , 1965, Cancer research.
[96] C. Heidelberger,et al. Studies on Fluorinated Pyrimidines XVI. Metabolism of 5-Fluorouracil-2-C14 and 5-Fluoro-2′-deoxyuridine-2-C14 in Cancer Patients , 1963 .
[97] R. W. Brockman,et al. MECHANISMS OF RESISTANCE TO ANTICANCER AGENTS. , 1963, Advances in cancer research.
[98] C. Heidelberger,et al. Studies on Fluorinated Pyrimidines XVII. Tissue Distribution of 5-Fluorouracil-2-C14 and 5-Fluoro-2′-deoxyuridine in Cancer Patients , 1963 .
[99] N. Morris,et al. Studies concerning the inhibition of cellular reproduction by deoxyribonucleosides: I. Inhibition of the synthesis of deoxycytidine by a phosphorylated derivative of thymidine , 1963 .
[100] R. Handschumacher,et al. Alterations in pyrimidine metabolism in L5178Y leukemia cells resistant to 6-azauridine. , 1961, Cancer research.
[101] R. W. Brockman,et al. Metabolism of uracil and 5-fluorouracil by drug-sensitive and by drug-resistant bacteria. , 1960, Biochimica et biophysica acta.