hERG potassium channels and cardiac arrhythmia

[1]  Jamie I Vandenberg,et al.  Tryptophan scanning mutagenesis of the HERG K+ channel: the S4 domain is loosely packed and likely to be lipid exposed , 2005, The Journal of physiology.

[2]  Roderick MacKinnon,et al.  Calibrated Measurement of Gating-Charge Arginine Displacement in the KvAP Voltage-Dependent K+ Channel , 2005, Cell.

[3]  Krista I Kinard,et al.  Molecular mapping of a site for Cd2+‐induced modification of human ether‐à‐go‐go‐related gene (hERG) channel activation , 2005, The Journal of physiology.

[4]  F. Bezanilla,et al.  Small vertical movement of a K+ channel voltage sensor measured with luminescence energy transfer , 2005, Nature.

[5]  E. Campbell,et al.  Voltage Sensor of Kv1.2: Structural Basis of Electromechanical Coupling , 2005, Science.

[6]  E. Campbell,et al.  Crystal Structure of a Mammalian Voltage-Dependent Shaker Family K+ Channel , 2005, Science.

[7]  A. Shrier,et al.  Identification of the cyclic-nucleotide-binding domain as a conserved determinant of ion-channel cell-surface localization , 2005, Journal of Cell Science.

[8]  F. Österberg,et al.  Exploring blocker binding to a homology model of the open hERG K+ channel using docking and molecular dynamics methods , 2005, FEBS letters.

[9]  Qiuming Gong,et al.  Degradation of Trafficking-defective Long QT Syndrome Type II Mutant Channels by the Ubiquitin-Proteasome Pathway* , 2005, Journal of Biological Chemistry.

[10]  S. Priori,et al.  A Novel Form of Short QT Syndrome (SQT3) Is Caused by a Mutation in the KCNJ2 Gene , 2005, Circulation research.

[11]  J. Li,et al.  A two-state homology model of the hERG K+ channel: application to ligand binding. , 2005, Bioorganic & medicinal chemistry letters.

[12]  Michael C Sanguinetti,et al.  Predicting drug-hERG channel interactions that cause acquired long QT syndrome. , 2005, Trends in pharmacological sciences.

[13]  Fabrizio De Ponti,et al.  QT prolongation through hERG K+ channel blockade: Current knowledge and strategies for the early prediction during drug development , 2005, Medicinal research reviews.

[14]  Jiesheng Kang,et al.  Discovery of a Small Molecule Activator of the Human Ether-a-go-go-Related Gene (HERG) Cardiac K+ Channel , 2005, Molecular Pharmacology.

[15]  A. Hoes,et al.  Anti-HERG activity and the risk of drug-induced arrhythmias and sudden death. , 2005, European heart journal.

[16]  A. Dubin,et al.  Identifying Modulators of hERG Channel Activity Using the PatchXpress® Planar Patch Clamp , 2005, Journal of biomolecular screening.

[17]  Michael C Sanguinetti,et al.  Regional Specificity of Human ether-a'-go-go-related Gene Channel Activation and Inactivation Gating* , 2005, Journal of Biological Chemistry.

[18]  Carlos G Vanoye,et al.  Expression of multiple KCNE genes in human heart may enable variable modulation of I(Ks). , 2005, Journal of molecular and cellular cardiology.

[19]  Y. Kuryshev,et al.  Pentamidine-Induced Long QT Syndrome and Block of hERG Trafficking , 2005, Journal of Pharmacology and Experimental Therapeutics.

[20]  Gea-Ny Tseng,et al.  Gating Charges in the Activation and Inactivation Processes of the hERG Channel , 2004, The Journal of general physiology.

[21]  S. Priori,et al.  CaV1.2 Calcium Channel Dysfunction Causes a Multisystem Disorder Including Arrhythmia and Autism , 2004, Cell.

[22]  C. January,et al.  Biology of cardiac arrhythmias: ion channel protein trafficking. , 2004, Circulation research.

[23]  B. Roux,et al.  Critical assessment of a proposed model of Shaker , 2004, FEBS letters.

[24]  G. Yellen,et al.  Intracellular gate opening in Shaker K+ channels defined by high-affinity metal bridges , 2004, Nature.

[25]  Gregory W. Kauffman,et al.  Physicochemical Features of the hERG Channel Drug Binding Site* , 2004, Journal of Biological Chemistry.

[26]  L. Messerini,et al.  herg1 Gene and HERG1 Protein Are Overexpressed in Colorectal Cancers and Regulate Cell Invasion of Tumor Cells , 2004, Cancer Research.

[27]  J. Brugada,et al.  Sudden Death Associated With Short-QT Syndrome Linked to Mutations in HERG , 2003, Circulation.

[28]  Michael C Sanguinetti,et al.  Gating currents associated with intramembrane charge displacement in HERG potassium channels , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[29]  S. Nattel,et al.  Canine Ventricular KCNE2 Expression Resides Predominantly in Purkinje Fibers , 2003, Circulation research.

[30]  A. Farrelly,et al.  Expression and function of KCNH2 (HERG) in the human jejunum. , 2003, American journal of physiology. Gastrointestinal and liver physiology.

[31]  M. Jiang,et al.  Negative Charges in the Transmembrane Domains of the HERG K Channel Are Involved in the Activation- and Deactivation-gating Processes , 2003, The Journal of general physiology.

[32]  Roy J. Vaz,et al.  Characterization of HERG potassium channel inhibition using CoMSiA 3D QSAR and homology modeling approaches. , 2003, Bioorganic & medicinal chemistry letters.

[33]  Youxing Jiang,et al.  The principle of gating charge movement in a voltage-dependent K+ channel , 2003, Nature.

[34]  M. Cadene,et al.  X-ray structure of a voltage-dependent K+ channel , 2003, Nature.

[35]  Robert Pearlstein,et al.  Understanding the structure-activity relationship of the human ether-a-go-go-related gene cardiac K+ channel. A model for bad behavior. , 2003, Journal of medicinal chemistry.

[36]  Benoît Roux,et al.  Structural basis of two-stage voltage-dependent activation in K+ channels , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[37]  Zhe Lu,et al.  Coupling between Voltage Sensors and Activation Gate in Voltage-gated K+ Channels , 2002, The Journal of general physiology.

[38]  A. Cavalli,et al.  Toward a pharmacophore for drugs inducing the long QT syndrome: insights from a CoMFA study of HERG K(+) channel blockers. , 2002, Journal of medicinal chemistry.

[39]  Youxing Jiang,et al.  Crystal structure and mechanism of a calcium-gated potassium channel , 2002, Nature.

[40]  Youxing Jiang,et al.  The open pore conformation of potassium channels , 2002, Nature.

[41]  E. Newell,et al.  Functional Up-regulation of HERG K+ Channels in Neoplastic Hematopoietic Cells* , 2002, The Journal of Biological Chemistry.

[42]  M. Sanguinetti,et al.  Interactions between S4-S5 Linker and S6 Transmembrane Domain Modulate Gating of HERG K+ Channels* , 2002, The Journal of Biological Chemistry.

[43]  W. Crumb,et al.  Three-dimensional quantitative structure-activity relationship for inhibition of human ether-a-go-go-related gene potassium channel. , 2002, The Journal of pharmacology and experimental therapeutics.

[44]  Stanley Nattel,et al.  A comparison of currents carried by HERG, with and without coexpression of MiRP1, and the native rapid delayed rectifier current. Is MiRP1 the missing link? , 2002, The Journal of physiology.

[45]  Gary Yellen,et al.  Fast and Slow Voltage Sensor Movements in HERG Potassium Channels , 2002, The Journal of general physiology.

[46]  R. MacKinnon,et al.  Chemistry of ion coordination and hydration revealed by a K+ channel–Fab complex at 2.0 Å resolution , 2001, Nature.

[47]  S. Subramony,et al.  Mutations in Kir2.1 Cause the Developmental and Episodic Electrical Phenotypes of Andersen's Syndrome , 2001, Cell.

[48]  S. Priori,et al.  Mutations in the Cardiac Ryanodine Receptor Gene (hRyR2) Underlie Catecholaminergic Polymorphic Ventricular Tachycardia , 2001, Circulation.

[49]  Jun Chen,et al.  A structural basis for drug-induced long QT syndrome. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[50]  D M Roden,et al.  A common polymorphism associated with antibiotic-induced cardiac arrhythmia. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[51]  C Antzelevitch,et al.  The potential for QT prolongation and proarrhythmia by non-antiarrhythmic drugs: clinical and regulatory implications. Report on a policy conference of the European Society of Cardiology. , 2000, European heart journal.

[52]  Glenn I. Fishman,et al.  Cyclic AMP regulates the HERG K+ channel by dual pathways , 2000, Current Biology.

[53]  G. Fishman,et al.  The Dominant Negative LQT2 Mutation A561V Reduces Wild-type HERG Expression* , 2000, The Journal of Biological Chemistry.

[54]  J. Schwarz,et al.  Erg1, erg2 and erg3 K channel subunits are able to form heteromultimers , 2000, Pflügers Archiv.

[55]  A. Wilde,et al.  Cardiac conduction defects associate with mutations in SCN5A , 1999, Nature Genetics.

[56]  M. Jiang,et al.  Effects of outer mouth mutations on hERG channel function: a comparison with similar mutations in the Shaker channel. , 1999, Biophysical journal.

[57]  I. Zhulin,et al.  PAS Domains: Internal Sensors of Oxygen, Redox Potential, and Light , 1999, Microbiology and Molecular Biology Reviews.

[58]  C. January,et al.  Novel mechanism associated with an inherited cardiac arrhythmia: defective protein trafficking by the mutant HERG (G601S) potassium channel. , 1999, Circulation.

[59]  M. Keating,et al.  MiRP1 Forms IKr Potassium Channels with HERG and Is Associated with Cardiac Arrhythmia , 1999, Cell.

[60]  Steven L. Cohen,et al.  DEPARTMENT OF PHYSIOLOGY: 2016/2017 LT/LE ORGANIZATION CHART , 2016 .

[61]  D. Roden,et al.  Cisapride‐Induced Torsades de Pointes , 1998, Journal of cardiovascular electrophysiology.

[62]  R. Nagai,et al.  Novel mechanism of HERG current suppression in LQT2: shift in voltage dependence of HERG inactivation. , 1998, Circulation research.

[63]  D. Beuckelmann,et al.  Simulation study of cellular electric properties in heart failure. , 1998, Circulation research.

[64]  B. Chait,et al.  The structure of the potassium channel: molecular basis of K+ conduction and selectivity. , 1998, Science.

[65]  L. Kiss,et al.  Modulation of C-type inactivation by K+ at the potassium channel selectivity filter. , 1998, Biophysical journal.

[66]  G. Breithardt,et al.  Genetic basis and molecular mechanism for idiopathic ventricular fibrillation , 1998, Nature.

[67]  D. Mckinnon,et al.  Identification of Two Nervous System-Specific Members of theerg Potassium Channel Gene Family , 1997, The Journal of Neuroscience.

[68]  N. Copeland,et al.  Two isoforms of the mouse ether-a-go-go-related gene coassemble to form channels with properties similar to the rapidly activating component of the cardiac delayed rectifier K+ current. , 1997, Circulation research.

[69]  M. Sanguinetti,et al.  Mutations in the hminK gene cause long QT syndrome and suppress lKs function , 1997, Nature Genetics.

[70]  E Wanke,et al.  A Novel Role for HERG K+ Channels: Spike‐Frequency Adaptation , 1997, The Journal of physiology.

[71]  M. Sanguinetti,et al.  Coassembly of KVLQT1 and minK (IsK) proteins to form cardiac IKS potassium channel , 1996, Nature.

[72]  Jacques Barhanin,et al.  KvLQT1 and IsK (minK) proteins associate to form the IKS cardiac potassium current , 1996, Nature.

[73]  M. Sanguinetti,et al.  Fast inactivation causes rectification of the IKr channel , 1996, The Journal of general physiology.

[74]  M. Sanguinetti,et al.  Spectrum of HERG K+-channel dysfunction in an inherited cardiac arrhythmia. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[75]  Gary Yellen,et al.  The inward rectification mechanism of the HERG cardiac potassium channel , 1996, Nature.

[76]  Ehud Y. Isacoff,et al.  Transmembrane Movement of the Shaker K+ Channel S4 , 1996, Neuron.

[77]  G. Landes,et al.  Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias , 1996, Nature Genetics.

[78]  G. Yellen,et al.  Modulation of K+ current by frequency and external [K+]: A tale of two inactivation mechanisms , 1995, Neuron.

[79]  A. George,et al.  Molecular mechanism for an inherited cardiac arrhythmia , 1995, Nature.

[80]  G. Robertson,et al.  HERG, a human inward rectifier in the voltage-gated potassium channel family. , 1995, Science.

[81]  M. Sanguinetti,et al.  A mechanistic link between an inherited and an acquird cardiac arrthytmia: HERG encodes the IKr potassium channel , 1995, Cell.

[82]  Arthur J Moss,et al.  SCN5A mutations associated with an inherited cardiac arrhythmia, long QT syndrome , 1995, Cell.

[83]  E. Green,et al.  A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome , 1995, Cell.

[84]  J. Warmke,et al.  A family of potassium channel genes related to eag in Drosophila and mammals. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[85]  M. Sanguinetti,et al.  Two components of cardiac delayed rectifier K+ current. Differential sensitivity to block by class III antiarrhythmic agents , 1990, The Journal of general physiology.

[86]  A. Shrier,et al.  Repolarization current in embryonic chick atrial heart cells. , 1988, The Journal of physiology.

[87]  T. Shibasaki,et al.  Conductance and kinetics of delayed rectifier potassium channels in nodal cells of the rabbit heart. , 1987, The Journal of physiology.

[88]  D. Noble,et al.  Outward membrane currents activated in the plateau range of potentials in cardiac Purkinje fibres , 1969, The Journal of physiology.