An overview of inhibitors of Na(+)/H(+) exchanger.

[1]  N. Ohashi,et al.  SM-20220, a Na+/H+ exchanger inhibitor: effects on ischemic brain damage through edema and neutrophil accumulation in a rat middle cerebral artery occlusion model , 2002, Brain Research.

[2]  B. Masereel,et al.  Synthesis and biological evaluation of aroylguanidines related to amiloride as inhibitors of the human platelet Na(+)/H(+) exchanger. , 2002, Bioorganic & medicinal chemistry.

[3]  K. Kusumoto,et al.  Novel, non-acylguanidine-type Na(+)/H(+) exchanger inhibitors: synthesis and pharmacology of 5-tetrahydroquinolinylidene aminoguanidine derivatives. , 2002, Journal of medicinal chemistry.

[4]  K. Kusumoto,et al.  In vitro and in vivo pharmacology of a structurally novel Na+‐H+ exchange inhibitor, T‐162559 , 2002, British journal of pharmacology.

[5]  M. Marber,et al.  Na(+)/H(+) exchange inhibitors for cardioprotective therapy: progress, problems and prospects. , 2002, Journal of the American College of Cardiology.

[6]  K. H. Langer,et al.  S3226, a novel NHE3 inhibitor, attenuates ischemia-induced acute renal failure in rats. , 2001, Kidney international.

[7]  H. Suryapranata,et al.  The Na(+)/H(+) exchange inhibitor eniporide as an adjunct to early reperfusion therapy for acute myocardial infarction. Results of the evaluation of the safety and cardioprotective effects of eniporide in acute myocardial infarction (ESCAMI) trial. , 2001, Journal of the American College of Cardiology.

[8]  G. Koliakos,et al.  The Effect of Insulin on Na+-H+ Antiport Activity of Obese and Normal Subjects Erythrocytes , 2001, Cellular Physiology and Biochemistry.

[9]  J. Pilitsis,et al.  Inhibition of Na+/H+ exchange by SM-20220 attenuates free fatty acid efflux in rat cerebral cortex during ischemia–reperfusion injury , 2001, Brain Research.

[10]  K. J. Yost,et al.  Arylcyclopropanecarboxyl guanidines as novel, potent, and selective inhibitors of the sodium hydrogen exchanger isoform-1. , 2001, Journal of medicinal chemistry.

[11]  M. Numata,et al.  Molecular Cloning and Characterization of a Novel (Na+,K+)/H+ Exchanger Localized to the trans-Golgi Network* , 2001, The Journal of Biological Chemistry.

[12]  K. Aihara,et al.  TY-12533, a novel Na(+)/H(+) exchange inhibitor, prevents myocardial stunning in dogs. , 2001, European journal of pharmacology.

[13]  R. J. Hill,et al.  A novel sodium-hydrogen exchanger isoform-1 inhibitor, zoniporide, reduces ischemic myocardial injury in vitro and in vivo. , 2001, The Journal of pharmacology and experimental therapeutics.

[14]  R. J. Hill,et al.  Discovery of zoniporide: a potent and selective sodium-hydrogen exchanger type 1 (NHE-1) inhibitor with high aqueous solubility. , 2001, Bioorganic & medicinal chemistry letters.

[15]  H. White,et al.  Inhibition of the Sodium-Hydrogen Exchanger With Cariporide to Prevent Myocardial Infarction in High-Risk Ischemic Situations: Main Results of the GUARDIAN Trial , 2000, Circulation.

[16]  J. Phillis,et al.  Inhibition of Na+/H+ exchange by 5-(N-ethyl-N-isopropyl)-amiloride reduces free fatty acid efflux from the ischemic reperfused rat cerebral cortex , 2000, Brain Research.

[17]  C. Hoornaert,et al.  Pharmacological profile of SL 59.1227, a novel inhibitor of the sodium/hydrogen exchanger , 2000, British journal of pharmacology.

[18]  S. Yamamoto,et al.  Effect of SMP-300, a new Na+/H+ exchange inhibitor, on myocardial ischemia and experimental angina models in rats. , 2000, Japanese journal of pharmacology.

[19]  K. Aihara,et al.  Cardioprotective effect of TY-12533, a novel Na(+)/H(+) exchange inhibitor, on ischemia/reperfusion injury. , 2000, European journal of pharmacology.

[20]  S. Yamamoto,et al.  Reduction of myocardial infarct size by SM-20550, a novel Na(+)/H(+) exchange inhibitor, in rabbits. , 2000, European journal of pharmacology.

[21]  F. Sheehan,et al.  Cardioprotective effects of the Na(+)/H(+) exchange inhibitor cariporide in patients with acute anterior myocardial infarction undergoing direct PTCA. , 2000, Circulation.

[22]  G. Gross,et al.  Inhibition of the Na(+)/H(+) exchanger attenuates phase 1b ischemic arrhythmias and reperfusion-induced ventricular fibrillation. , 2000, European journal of pharmacology.

[23]  N. Ohashi,et al.  SM‐20220, a Potent Na+/H+ Exchange Inhibitor, Improves Consciousness Recovery and Neurological Outcome Following Transient Cerebral Ischaemia in Gerbils , 2000, The Journal of pharmacy and pharmacology.

[24]  M. Numata,et al.  Kinetic and Pharmacological Properties of Human Brain Na+/H+ Exchanger Isoform 5 Stably Expressed in Chinese Hamster Ovary Cells* , 2000, The Journal of Biological Chemistry.

[25]  G. Gross,et al.  Inhibition of the Na(+)/H(+) exchanger confers greater cardioprotection against 90 minutes of myocardial ischemia than ischemic preconditioning in dogs. , 1999, Circulation.

[26]  N. Ohashi,et al.  Cerebroprotective properties of SM-20220, a potent Na(+)/H(+) exchange inhibitor, in transient cerebral ischemia in rats. , 1999, European journal of pharmacology.

[27]  R. Nagai,et al.  A Na+-H+ exchange inhibitor (SM-20550) protects from microvascular deterioration and myocardial injury after reperfusion. , 1999, European journal of pharmacology.

[28]  H. Yamashita,et al.  Effects of MS-31-038, a Novel Na+-H+ Exchange Inhibitor, on the Myocardial Infarct Size in Rats after Postischemic Administration , 1999, Arzneimittelforschung.

[29]  G. Shull,et al.  Molecular Cloning, Genomic Organization, and Functional Expression of Na+/H+ Exchanger Isoform 5 (NHE5) from Human Brain* , 1999, The Journal of Biological Chemistry.

[30]  G. Burckhardt,et al.  S3226, a novel inhibitor of Na+/H+ exchanger subtype 3 in various cell types , 1998, Pflügers Archiv.

[31]  G. Gross,et al.  A new sodium/hydrogen exchange inhibitor, EMD 85131, limits infarct size in dogs when administered before or after coronary artery occlusion. , 1998, The Journal of pharmacology and experimental therapeutics.

[32]  M. Numata,et al.  Identification of a Mitochondrial Na+/H+Exchanger* , 1998, The Journal of Biological Chemistry.

[33]  S. Grinstein,et al.  Na+/H+ Exchangers of Mammalian Cells* , 1997, The Journal of Biological Chemistry.

[34]  R. Gericke,et al.  (2-Methyl-5-(methylsulfonyl)benzoyl)guanidine Na+/H+ antiporter inhibitors. , 1997, Journal of medicinal chemistry.

[35]  H. M. Piper,et al.  The role of Na+/H+ exchange in ischemia-reperfusion , 1996, Basic Research in Cardiology.

[36]  M. Leppert,et al.  Molecular cloning and physical and genetic mapping of a novel human Na+/H+ exchanger (NHE5/SLC9A5) to chromosome 16q22.1. , 1995, Genomics.

[37]  W. Linz,et al.  Protective effects of HOE642, a selective sodium-hydrogen exchange subtype 1 inhibitor, on cardiac ischaemia and reperfusion. , 1995, Cardiovascular research.

[38]  D. Bar-Sagi,et al.  An SH3 binding region in the epithelial Na+ channel (alpha rENaC) mediates its localization at the apical membrane. , 1994, The EMBO journal.

[39]  J. Pouysségur,et al.  The Na+/H+ exchanger isoform 1 (NHE1) is a novel member of the calmodulin-binding proteins. Identification and characterization of calmodulin-binding sites. , 1994, The Journal of biological chemistry.

[40]  G. Shull,et al.  Functional properties of the rat Na/H exchanger NHE-2 isoform expressed in Na/H exchanger-deficient Chinese hamster ovary cells. , 1993, The Journal of biological chemistry.

[41]  L. Fliegel,et al.  The Na+/H+ exchanger: an update on structure, regulation and cardiac physiology. , 1993, The Biochemical journal.

[42]  L. Fliegel,et al.  Cloning and analysis of the human myocardial Na+/H+ exchanger , 1993, Molecular and Cellular Biochemistry.

[43]  J. Pouysségur,et al.  Cloning and expression of a rabbit cDNA encoding a serum-activated ethylisopropylamiloride-resistant epithelial Na+/H+ exchanger isoform (NHE-2). , 1993, The Journal of biological chemistry.

[44]  G. Shull,et al.  Primary structure and functional expression of a novel gastrointestinal isoform of the rat Na/H exchanger. , 1993, Journal of Biological Chemistry.

[45]  W. Linz,et al.  Hoe 694, a new Na+/H+ exchange inhibitor and its effects in cardiac ischaemia , 1993, British journal of pharmacology.

[46]  D. Rosskopf,et al.  Platelet Na+‐H+ exchanger activity in normotensive and hypertensive subjects: effect of enalapril therapy upon antiport activity , 1992, Journal of hypertension.

[47]  S. Brant,et al.  Cloning and sequencing of a rabbit cDNA encoding an intestinal and kidney-specific Na+/H+ exchanger isoform (NHE-3). , 1992, The Journal of biological chemistry.

[48]  G. Shull,et al.  Molecular cloning of putative members of the Na/H exchanger gene family. cDNA cloning, deduced amino acid sequence, and mRNA tissue expression of the rat Na/H exchanger NHE-1 and two structurally related proteins. , 1992, The Journal of biological chemistry.

[49]  R. Goldszer,et al.  Kinetic Abnormalities of the Red Blood Cell Sodium-Proton Exchange in Hypertensive Patients , 1991, Hypertension.

[50]  G. Radda,et al.  Evidence for abnormal Na+/H+ antiport activity detected by phosphorus nuclear magnetic resonance spectroscopy in exercising skeletal muscle of patients with essential hypertension. , 1990, Clinical science.

[51]  C. Sardet,et al.  Molecular cloning, primary structure, and expression of the human growth factor-activatable Na+ H+ , 1989, Cell.

[52]  J. Pouysségur,et al.  Molecular physiology of vertebrate Na+/H+ exchangers. , 1997, Physiological reviews.

[53]  D. Barber,et al.  Ga12 Differentially Regulates Na-H Exchanger Isoforms* , 1996 .

[54]  P. Aronson.  Kinetic properties of the plasma membrane Na+-H+ exchanger. , 1985, Annual review of physiology.