15 – Phytochemical and biological research of Panax medicinal resources

[1]  Shanfa Lu,et al.  Identification of mRNA-like non-coding RNAs and validation of a mighty one named MAR in Panax ginseng. , 2015, Journal of integrative plant biology.

[2]  Xiao-juan Ma,et al.  Effects of Panax Quinquefolium Saponin on phosphatidylinositol 3-kinase/serine threonine kinase pathway of neonatal rat myocardial cells subjected to hypoxia , 2015, Chinese Journal of Integrative Medicine.

[3]  Y. Kim,et al.  Ginsenoside Rh1 induces mouse osteoblast growth and differentiation through the bone morphogenetic protein 2/runt‐related gene 2 signalling pathway , 2014, The Journal of pharmacy and pharmacology.

[4]  Wenkui Yu,et al.  Anti-inflammatory effect of ginsenoside Rb1 contributes to the recovery of gastrointestinal motility in the rat model of postoperative ileus. , 2014, Biological & pharmaceutical bulletin.

[5]  J. Kovacs,et al.  Influence of Panax ginseng on the Steady State Pharmacokinetic Profile of Lopinavir‐Ritonavir in Healthy Volunteers , 2014, Pharmacotherapy.

[6]  Wan-ying Wu,et al.  Saponins in the genus Panax L. (Araliaceae): a systematic review of their chemical diversity. , 2014, Phytochemistry.

[7]  P. Xu,et al.  Association of GLP-1 secretion with anti-hyperlipidemic effect of ginsenosides in high-fat diet fed rats. , 2014, Metabolism: clinical and experimental.

[8]  Chong-Zhi Wang,et al.  Adulteration and cultivation region identification of American ginseng using HPLC coupled with multivariate analysis. , 2014, Journal of pharmaceutical and biomedical analysis.

[9]  K. Shimizu,et al.  20(S)-Ginsenoside Rh2 as aldose reductase inhibitor from Panax ginseng. , 2014, Bioorganic & medicinal chemistry letters.

[10]  R. Keep,et al.  Antioxidative effects of Panax notoginseng saponins in brain cells. , 2014, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[11]  R. Qiang,et al.  Treatment with ginseng total saponins improves the neurorestoration of rat after traumatic brain injury. , 2014, Journal of ethnopharmacology.

[12]  Mina Kim,et al.  Ginseng treatment reverses obesity and related disorders by inhibiting angiogenesis in female db/db mice. , 2014, Journal of ethnopharmacology.

[13]  Eunhye Kim,et al.  Triterpene glycosides from red ginseng marc and their anti-inflammatory activities. , 2014, Bioorganic & medicinal chemistry letters.

[14]  R. Pi,et al.  Ginsenoside Rd ameliorates experimental autoimmune encephalomyelitis in C57BL/6 mice , 2014, Journal of neuroscience research.

[15]  Guibo Sun,et al.  Notoginsenoside R1 attenuates amyloid-β-induced damage in neurons by inhibiting reactive oxygen species and modulating MAPK activation. , 2014, International immunopharmacology.

[16]  He Zhu,et al.  Discrimination of leaves of Panax ginseng and P. quinquefolius by ultra high performance liquid chromatography quadrupole/time-of-flight mass spectrometry based metabolomics approach. , 2014, Journal of pharmaceutical and biomedical analysis.

[17]  Zhiyong Zhou,et al.  Protective effect of saponins extract from Panax japonicus on myocardial infarction: involvement of NF‐κB, Sirt1 and mitogen‐activated protein kinase signalling pathways and inhibition of inflammation , 2014, The Journal of pharmacy and pharmacology.

[18]  Guibo Sun,et al.  Attenuation of Aβ25-35-induced parallel autophagic and apoptotic cell death by gypenoside XVII through the estrogen receptor-dependent activation of Nrf2/ARE pathways. , 2014, Toxicology and applied pharmacology.

[19]  Lei Wu,et al.  Panax ginseng therapy for chronic obstructive pulmonary disease: a clinical trial protocol and pilot study , 2014, Chinese Medicine.

[20]  Liang Liu,et al.  Quantitative Comparison and Metabolite Profiling of Saponins in Different Parts of the Root of Panax notoginseng , 2014, Journal of agricultural and food chemistry.

[21]  B. Jeon,et al.  Stereospecific effects of ginsenoside 20-Rg3 inhibits TGF-β1-induced epithelial-mesenchymal transition and suppresses lung cancer migration, invasion and anoikis resistance. , 2014, Toxicology.

[22]  I. Mucalo,et al.  Effect of Rg3-enriched Korean red ginseng (Panax ginseng) on arterial stiffness and blood pressure in healthy individuals: a randomized controlled trial. , 2014, Journal of the American Society of Hypertension : JASH.

[23]  D. Rahelić,et al.  Modulation of endothelial function by Korean red ginseng (Panax ginseng C.A. Meyer) and its components in healthy individuals: a randomized controlled trial. , 2014, Cardiovascular therapeutics.

[24]  S. Subramaniyam,et al.  Transcript expression profiling for adventitious roots of Panax ginseng Meyer. , 2014, Gene.

[25]  P. Xiao,et al.  Network Pharmacology: A Rosetta Stone for Traditional Chinese Medicine , 2014, Drug development research.

[26]  W. Xu,et al.  Ginsenoside Rb3 Protects Cardiomyocytes against Ischemia-Reperfusion Injury via the Inhibition of JNK-Mediated NF-κB Pathway: A Mouse Cardiomyocyte Model , 2014, PloS one.

[27]  Yaoyan Dun,et al.  Chikusetsu Saponin V Attenuates MPP+-Induced Neurotoxicity in SH-SY5Y Cells via Regulation of Sirt1/Mn-SOD and GRP78/Caspase-12 Pathways , 2014, International journal of molecular sciences.

[28]  Mihi Yang,et al.  Effects of Korean red ginseng (Panax Ginseng Meyer) on bisphenol A exposure and gynecologic complaints: single blind, randomized clinical trial of efficacy and safety , 2014, BMC Complementary and Alternative Medicine.

[29]  Jie Wang,et al.  Protective Effects of Panax Notoginseng Saponins on Cardiovascular Diseases: A Comprehensive Overview of Experimental Studies , 2014, Evidence-based complementary and alternative medicine : eCAM.

[30]  Kyung-Su Park,et al.  Red Ginseng Extract Ameliorates Autoimmune Arthritis via Regulation of STAT3 Pathway, Th17/Treg Balance, and Osteoclastogenesis in Mice and Human , 2014, Mediators of inflammation.

[31]  Hailian Shi,et al.  p38 MAPK and ERK1/2 pathways are involved in the pro-apoptotic effect of notoginsenoside Ft1 on human neuroblastoma SH-SY5Y cells. , 2014, Life sciences.

[32]  Chuanzheng Sun,et al.  Protective Mechanism of Panax notoginseng Saponins on Rat Hemorrhagic Shock Model in Recovery Stage , 2014, Cell Biochemistry and Biophysics.

[33]  Yixiao Xu,et al.  Notoginsenoside R1 attenuates hypoxia and hypercapnia-induced vasoconstriction in isolated rat pulmonary arterial rings by reducing the expression of ERK. , 2014, The American journal of Chinese medicine.

[34]  Qinbo Yang,et al.  Panax notoginseng saponins (PNS) inhibits breast cancer metastasis. , 2014, Journal of ethnopharmacology.

[35]  Ye Li,et al.  The haematopoietic effect of Panax japonicus on blood deficiency model mice. , 2014, Journal of ethnopharmacology.

[36]  V. Vuksan,et al.  Effects of Korean White Ginseng (Panax Ginseng C.A. Meyer) on Vascular and Glycemic Health in Type 2 Diabetes: Results of a Randomized, Double Blind, Placebo-controlled, Multiple-crossover, Acute Dose Escalation Trial , 2014, Clinical nutrition research.

[37]  Jianguo Dai,et al.  The Antidepressant Effects of Ginseng Total Saponins in Male C57BL/6 N Mice by Enhancing Hippocampal Inhibitory Phosphorylation of GSK‐3β , 2014, Phytotherapy research : PTR.

[38]  Xinyi Mu,et al.  Ginsenoside Rg1 Prevents Cognitive Impairment and Hippocampus Senescence in a Rat Model of D-Galactose-Induced Aging , 2014, PloS one.

[39]  W. Oh,et al.  Dammarane triterpenes as potential SIRT1 activators from the leaves of Panax ginseng. , 2014, Journal of natural products.

[40]  G. Gessa,et al.  Protective effect of Panax ginseng in cisplatin-induced cachexia in rats. , 2014, Future oncology.

[41]  Shuying Liu,et al.  Antioxidant activities of the oligosaccharides from the roots, flowers and leaves of Panax ginseng C.A. Meyer. , 2014, Carbohydrate polymers.

[42]  M. Chang,et al.  Panax ginseng induces the expression of CatSper genes and sperm hyperactivation , 2014, Asian journal of andrology.

[43]  Songhua Hu,et al.  Rapeseed Oil and Ginseng Saponins Work Synergistically To Enhance Th1 and Th2 Immune Responses Induced by the Foot-and-Mouth Disease Vaccine , 2014, Clinical and Vaccine Immunology.

[44]  Qinbo Yang,et al.  Bidirectional regulation of angiogenesis and miR-18a expression by PNS in the mouse model of tumor complicated by myocardial ischemia , 2014, BMC Complementary and Alternative Medicine.

[45]  Hubiao Chen,et al.  The Melanogenesis-Inhibitory Effect and the Percutaneous Formulation of Ginsenoside Rb1 , 2014, AAPS PharmSciTech.

[46]  X. Fang,et al.  Ginsenoside Rd Attenuates Mitochondrial Permeability Transition and Cytochrome c Release in Isolated Spinal Cord Mitochondria: Involvement of Kinase-Mediated Pathways , 2014, International journal of molecular sciences.

[47]  B. Cho,et al.  Blood pressure lowering effect of Korea ginseng derived ginseol K-g1. , 2014, The American journal of Chinese medicine.

[48]  S. Kwon,et al.  20(S)-Ginsenoside Rg3 is a novel inhibitor of autophagy and sensitizes hepatocellular carcinoma to doxorubicin , 2014, Oncotarget.

[49]  S. Kang,et al.  Panax red ginseng extract regulates energy expenditures by modulating PKA dependent lipid mobilization in adipose tissue. , 2014, Biochemical and biophysical research communications.

[50]  Chunjie Wu,et al.  Panaxatriol Saponins Attenuated Oxygen-Glucose Deprivation Injury in PC12 Cells via Activation of PI3K/Akt and Nrf2 Signaling Pathway , 2014, Oxidative medicine and cellular longevity.

[51]  I. Mucalo,et al.  American Ginseng Extract (Panax quinquefolius L.) Is Safe in Long-Term Use in Type 2 Diabetic Patients , 2014, Evidence-based complementary and alternative medicine : eCAM.

[52]  L. Xiong,et al.  Ginsenoside Rd Attenuates Tau Protein Phosphorylation Via the PI3K/AKT/GSK-3β Pathway After Transient Forebrain Ischemia , 2014, Neurochemical Research.

[53]  J. Lee,et al.  Ginsenoside Rg3 enhances islet cell function and attenuates apoptosis in mouse islets. , 2014, Transplantation proceedings.

[54]  N. Lin,et al.  Treatment with Panax Ginseng Antagonizes the Estrogen Decline in Ovariectomized Mice , 2014, International journal of molecular sciences.

[55]  Liang Yang,et al.  Effects of radix ginseng on microbial infections: a narrative review. , 2014, Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.

[56]  Lingqun Zhu,et al.  Panax notoginseng saponins promotes stroke recovery by influencing expression of Nogo-A, NgR and p75NGF, in vitro and in vivo. , 2014, Biological & pharmaceutical bulletin.

[57]  Shuying Liu,et al.  Anti-tumour and immunomodulatory activities of oligosaccharides isolated from Panax ginseng C.A. Meyer. , 2014, International journal of biological macromolecules.

[58]  William Z. Xu,et al.  Isolation and Immunosuppressive Effects of 6″-O-Acetylginsenoside Rb1 Extracted from North American Ginseng , 2014, Planta Medica.

[59]  J. Xia,et al.  Ginsenoside Rg1 induces apoptosis through inhibition of the EpoR-mediated JAK2/STAT5 signalling pathway in the TF-1/ Epo human leukemia cell line. , 2014, Asian Pacific journal of cancer prevention : APJCP.

[60]  Yitao Wang,et al.  Saponins of Panax notoginseng: chemistry, cellular targets and therapeutic opportunities in cardiovascular diseases , 2014, Expert opinion on investigational drugs.

[61]  Ping Chen,et al.  Polysaccharides from Panax japonicus C.A. Meyer and their antioxidant activities. , 2014, Carbohydrate polymers.

[62]  Yu-Na Lee,et al.  Immunomodulatory Activity of Red Ginseng against Influenza A Virus Infection , 2014, Nutrients.

[63]  Hong-Il Choi,et al.  Evidence of genome duplication revealed by sequence analysis of multi-loci expressed sequence tag–simple sequence repeat bands in Panax ginseng Meyer , 2014, Journal of ginseng research.

[64]  Thi Hong Van Le,et al.  Processed Vietnamese ginseng: Preliminary results in chemistry and biological activity , 2013, Journal of ginseng research.

[65]  Tae-Jin Yang,et al.  Practical application of DNA markers for high-throughput authentication of Panax ginseng and Panax quinquefolius from commercial ginseng products , 2013, Journal of ginseng research.

[66]  Dawei Li,et al.  New dammarane-type triterpenoids from the leaves of Panax notoginseng and their protein tyrosine phosphatase 1B inhibitory activity , 2013, Journal of ginseng research.

[67]  Gyo In,et al.  Metabolomic approach for discrimination of processed ginseng genus (Panax ginseng and Panax quinquefolius) using UPLC-QTOF MS , 2013, Journal of ginseng research.

[68]  W. Oh,et al.  Dammarane triterpenes from the leaves of Panax ginseng enhance cellular immunity. , 2014, Bioorganic & medicinal chemistry.

[69]  Ming Li,et al.  A Simple Strategy for Development of Single Nucleotide Polymorphisms from Non-Model Species and Its Application in Panax , 2013, International journal of molecular sciences.

[70]  P. Marriott,et al.  Gas chromatography/mass spectrometry-based metabolic profiling and differentiation of ginseng roots according to cultivation age using variable selection. , 2013, Journal of AOAC International.

[71]  Shilin Chen,et al.  A fast SNP identification and analysis of intraspecific variation in the medicinal Panax species based on DNA barcoding. , 2013, Gene.

[72]  J. Wen,et al.  Complete Sequencing of Five Araliaceae Chloroplast Genomes and the Phylogenetic Implications , 2013, PloS one.

[73]  S. Nah,et al.  Yin and Yang of ginseng pharmacology: ginsenosides vs gintonin , 2013, Acta Pharmacologica Sinica.

[74]  A. Schetter,et al.  A Key Role of microRNA-29b for the Suppression of Colon Cancer Cell Migration by American Ginseng , 2013, PloS one.

[75]  Huiting Xue,et al.  The Inhibitory Effects of a Rhamnogalacturonan Ι (RG-I) Domain from Ginseng Pectin on Galectin-3 and Its Structure-Activity Relationship* , 2013, The Journal of Biological Chemistry.

[76]  Lan-Sook Lee,et al.  Hypolipidemic and Antioxidant Properties of Phenolic Compound-Rich Extracts from White Ginseng (Panax ginseng) in Cholesterol-Fed Rabbits , 2013, Molecules.

[77]  D. Lu,et al.  Two novel dammarane-type compounds from the leaves and stems of Panax quinquefolium L. , 2013, Journal of Asian natural products research.

[78]  Changsun Choi,et al.  Reduction of hepatitis A virus on FRhK-4 cells treated with Korean red ginseng extract and ginsenosides. , 2013, Journal of food science.

[79]  A. Shashkov,et al.  Malonyl-ginsenoside content of a cell-suspension culture of Panax japonicus var. repens. , 2013, Phytochemistry.

[80]  Ryan S. Austin,et al.  The root transcriptome for North American ginseng assembled and profiled across seasonal development , 2013, BMC Genomics.

[81]  J. Cho,et al.  20S-dihydroprotopanaxatriol modulates functional activation of monocytes and macrophages , 2013, Journal of ginseng research.

[82]  Y. Li,et al.  Transcriptome analysis reveals ginsenosides biosynthetic genes, microRNAs and simple sequence repeats in Panax ginsengC. A. Meyer , 2013, BMC Genomics.

[83]  Jeong Ah Kim,et al.  Sterols isolated from seeds of Panax ginseng and their antiinflammatory activities , 2013, Pharmacognosy magazine.

[84]  Hari Prasad Devkota,et al.  Saponins composition of rhizomes, taproots, and lateral roots of Satsuma-ninjin (Panax japonicus). , 2013, Chemical & pharmaceutical bulletin.

[85]  Hari Prasad Devkota,et al.  Four new triterpenoid saponins from the leaves of Panax japonicus grown in southern Miyazaki Prefecture (4). , 2013, Chemical & pharmaceutical bulletin.

[86]  J. Ma,et al.  Oleanane-triterpenoids from Panax stipuleanatus inhibit NF-κB , 2013, Journal of ginseng research.

[87]  Hong-Il Choi,et al.  EST-SSR Marker Sets for Practical Authentication of All Nine Registered Ginseng Cultivars in Korea , 2012, Journal of ginseng research.

[88]  S. Yahara,et al.  New triterpenoid saponins from fruit specimens of Panax japonicus collected in Toyama prefecture and Hokkaido (2). , 2012, Chemical & pharmaceutical bulletin.

[89]  Dong-Hyun Kim.  Chemical Diversity of Panax ginseng, Panax quinquifolium, and Panax notoginseng , 2012, Journal of ginseng research.

[90]  Ying Li,et al.  Analysis of the transcriptome of Panax notoginseng root uncovers putative triterpene saponin-biosynthetic genes and genetic markers , 2011, BMC Genomics.

[91]  M. C. Nguyen,et al.  Oleanolic triterpene saponins from the roots of Panax bipinnatifidus. , 2011, Chemical & pharmaceutical bulletin.

[92]  Shiliang Zhou,et al.  Development and characterization of microsatellite markers for Panax notoginseng (Araliaceae), a Chinese traditional herb. , 2011, American journal of botany.

[93]  Young-Chang Kim,et al.  CAPS markers using mitochondrial consensus primers for molecular identification of Panax species and Korean ginseng cultivars (Panax ginseng C. A. Meyer) , 2011, Molecular Biology Reports.

[94]  Shiliang Zhou,et al.  DNA barcoding of Panax species. , 2011, Planta medica.

[95]  Hee-kyoung Kang,et al.  Oleanane-type triterpenoids from Panax stipuleanatus and their anticancer activities. , 2010, Bioorganic & medicinal chemistry letters.

[96]  Songnian Hu,et al.  Transcript profiles of Panax quinquefolius from flower, leaf and root bring new insights into genes related to ginsenosides biosynthesis and transcriptional regulation. , 2010, Physiologia plantarum.

[97]  Ying Li,et al.  De novo sequencing and analysis of the American ginseng root transcriptome using a GS FLX Titanium platform to discover putative genes involved in ginsenoside biosynthesis , 2010, BMC Genomics.

[98]  Chong-Zhi Wang,et al.  Detection of adulteration of notoginseng root extract with other panax species by quantitative HPLC coupled with PCA. , 2009, Journal of agricultural and food chemistry.

[99]  Kwang-tae Choi,et al.  Botanical characteristics, pharmacological effects and medicinal components of Korean Panax ginseng C A Meyer , 2008, Acta Pharmacologica Sinica.

[100]  Chieh-fu Chen,et al.  Comparison of the pharmacological effects of Panax ginseng and Panax quinquefolium , 2008, Acta Pharmacologica Sinica.

[101]  K. Zou,et al.  Comparative study on triterpene saponins of Ginseng drugs. , 2004, Planta medica.

[102]  J. Wen,et al.  Phylogeny of Panax using chloroplast trnC-trnD intergenic region and the utility of trnC-trnD in interspecific studies of plants. , 2004, Molecular phylogenetics and evolution.

[103]  Shu Zhu,et al.  Phylogenetic relationship in the genus Panax: inferred from chloroplast trnK gene and nuclear 18S rRNA gene sequences. , 2003, Planta medica.

[104]  X. Cui,et al.  Authentication of Panax notoginseng by 5S-rRNA spacer domain and random amplified polymorphic DNA (RAPD) analysis. , 2003, Planta medica.

[105]  Q. K. Tran,et al.  Hepatoprotective Effect of Majonoside R2, the Major Saponin from Vietnamese Ginseng (Panax vietnamensis) , 2002, Planta medica.