Sustained-release multiple-component cellulose acetate nanofibers fabricated using a modified coaxial electrospinning process

Two drawbacks of the traditional electrospinning process when used for producing nanofibers for drug release are that clogging of the spinneret is often experienced, and the fibers produced often exhibit a tailing-off of drug release over sustained periods. The present study investigates the preparation of ferulic acid (FA) sustained-release cellulose acetate (CA) nanofibers, in which a third component, polyvinylpyrrolidone (PVP), was included into the nanocomposites for an improved sustained drug release profile. A modified coaxial electrospinning process, in which only organic solvent N,N-dimethylacetamide was used as a sheath fluid, was exploited for a smooth and continuous fabrication of multiple-component nanofibers. Under an applied voltage of 16 kV and an optimized sheath-to-core flow rate ratio of 0.11, three types of FA/PVP/CA composite nanofibers (with varied of PVP content) were generated. These nanofibers had higher quality in terms of size and distribution of nanofiber diameter, as indicated by FESEM images. Analysis of double- and triple-component nanofibers by XRD, DSC, and ATR-FTIR confirmed the compatibility of components producing homogenous fibers in both cases, but the triple-component nanofibers exhibited better release profiles over sustained periods than the double-component nanofibers in terms of release completeness, reduced tailing-off, and adjustable release rates. The modified coaxial process and the resulting multiple-component nanocomposites should provide a new way for developing novel drug sustained materials and drug delivery systems.

[1]  A. Xiang,et al.  Quantifying sustained release kinetics from a polymer matrix including burst effects , 2011 .

[2]  P. Supaphol,et al.  Effect of cross-linking on properties and release characteristics of sodium salicylate-loaded electrospun poly(vinyl alcohol) fibre mats , 2007 .

[3]  Doan Van Hong Thien,et al.  Electrospun chitosan/hydroxyapatite nanofibers for bone tissue engineering , 2013, Journal of Materials Science.

[4]  James Friend,et al.  Electrospinning carbon nanotube polymer composite nanofibers , 2006 .

[5]  Ge Mingqiao,et al.  Preparation of ultrafine fast‐dissolving cholecalciferol‐loaded poly(vinyl pyrrolidone) fiber mats via electrospinning , 2013 .

[6]  Cherng-ju Kim,et al.  Compressed Donut-Shaped Tablets with Zero-Order Release Kinetics , 1995, Pharmaceutical Research.

[7]  P. Zahedi,et al.  In vitro and in vivo evaluations of phenytoin sodium-loaded electrospun PVA, PCL, and their hybrid nanofibrous mats for use as active wound dressings , 2013, Journal of Materials Science.

[8]  C. Branford-White,et al.  Ester prodrug-loaded electrospun cellulose acetate fiber mats as transdermal drug delivery systems , 2010, Journal of materials science. Materials in medicine.

[9]  S. Ramakrishna,et al.  Expression of cardiac proteins in neonatal cardiomyocytes on PGS/fibrinogen core/shell substrate for Cardiac tissue engineering. , 2013, International journal of cardiology.

[10]  Jiashen Li,et al.  5-Fluorouracil-loaded poly-l-lactide fibrous membrane for the prevention of intestinal stent restenosis , 2013, Journal of Materials Science.

[11]  Deng-Guang Yu,et al.  Smoothening electrospinning and obtaining high-quality cellulose acetate nanofibers using a modified coaxial process , 2012, Journal of Materials Science.

[12]  I. Shakir,et al.  Electrospun fibers for tissue engineering, drug delivery, and wound dressing , 2013, Journal of Materials Science.

[13]  C. Branford-White,et al.  Electrospinning of Concentrated Polymer Solutions , 2010 .

[14]  A. C. Pandey,et al.  Small angle X-ray scattering and photoluminescence study of ZnO nanoparticles synthesized by hydrothermal process , 2007 .

[15]  John Layman,et al.  Release of tetracycline hydrochloride from electrospun poly(ethylene-co-vinylacetate), poly(lactic acid), and a blend. , 2002, Journal of controlled release : official journal of the Controlled Release Society.

[16]  G. Beretta,et al.  Non-covalent inclusion of ferulic acid with alpha-cyclodextrin improves photo-stability and delivery: NMR and modeling studies. , 2008, Journal of pharmaceutical and biomedical analysis.

[17]  Ioannis S Chronakis,et al.  Electrospun polyvinyl-alcohol nanofibers as oral fast-dissolving delivery system of caffeine and riboflavin. , 2013, Colloids and surfaces. B, Biointerfaces.

[18]  Tong Lin,et al.  Fiber generators in needleless electrospinning , 2012 .

[19]  P. Gatenholm,et al.  Electrospinning cellulosic nanofibers for biomedical applications: structure and in vitro biocompatibility , 2012, Cellulose.

[20]  Y. Liao,et al.  Linear drug release membrane prepared by a modified coaxial electrospinning process , 2013 .

[21]  The Compatibility of Acyclovir with Polyacrylonitrile in the Electrospun Drug-Loaded Nanofibers , 2010 .

[22]  Y. Li,et al.  Zero-order drug release cellulose acetate nanofibers prepared using coaxial electrospinning , 2013, Cellulose.

[23]  R. Gorga,et al.  Effect of Solution Parameters on Spontaneous Jet Formation and Throughput in Edge Electrospinning from a Fluid-Filled Bowl , 2012 .

[24]  P. Supaphol,et al.  Release characteristics of four model drugs from drug-loaded electrospun cellulose acetate fiber mats , 2007 .

[25]  Xianli Liu,et al.  Drug-Loaded Zein Nanofibers Prepared Using a Modified Coaxial Electrospinning Process , 2013, AAPS PharmSciTech.

[26]  T. Nguyen,et al.  Characteristics of curcumin-loaded poly (lactic acid) nanofibers for wound healing , 2013, Journal of Materials Science.

[27]  Horst A von Recum,et al.  Electrospinning: applications in drug delivery and tissue engineering. , 2008, Biomaterials.

[28]  K. Kanjanapongkul,et al.  Prediction of clogging time during electrospinning of zein solution: Scaling analysis and experimental verification , 2010 .

[29]  L. Zhai,et al.  Fabrication of ultrathin polyelectrolyte fibers and their controlled release properties. , 2007, Colloids and surfaces. B, Biointerfaces.

[30]  Younan Xia,et al.  Electrospinning of Nanofibers: Reinventing the Wheel? , 2004 .

[31]  Yanxiang Li,et al.  Electrospun membrane of cellulose acetate for heavy metal ion adsorption in water treatment , 2011 .

[32]  Deng-Guang Yu,et al.  Oral fast-dissolving drug delivery membranes prepared from electrospun polyvinylpyrrolidone ultrafine fibers , 2009, Nanotechnology.

[33]  Younan Xia,et al.  Electrospun Nanofibers for Regenerative Medicine , 2012, Advanced healthcare materials.

[34]  C. Branford-White,et al.  Preparation of core-shell PAN nanofibers encapsulated α-tocopherol acetate and ascorbic acid 2-phosphate for photoprotection. , 2011, Colloids and surfaces. B, Biointerfaces.

[35]  C J Kim,et al.  Release kinetics of coated, donut-shaped tablets for water soluble drugs. , 1999, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[36]  Y. Tseng,et al.  Sustainable release of carmustine from biodegradable poly[(d,l)-lactide-co-glycolide] nanofibrous membranes in the cerebral cavity: in vitro and in vivo studies , 2013, Expert opinion on drug delivery.

[37]  M. Prabhakaran,et al.  Emulsion electrospun vascular endothelial growth factor encapsulated poly(l-lactic acid-co-ε-caprolactone) nanofibers for sustained release in cardiac tissue engineering , 2012, Journal of Materials Science.

[38]  Y. Li,et al.  Electrospun biphasic drug release polyvinylpyrrolidone/ethyl cellulose core/sheath nanofibers. , 2013, Acta biomaterialia.

[39]  C. Branford-White,et al.  Improving polymer nanofiber quality using a modified co-axial electrospinning process. , 2011, Macromolecular rapid communications.

[40]  K. Kanjanapongkul,et al.  Investigation and Prevention of Clogging During Electrospinning of Zein Solution , 2010 .