Reconfigurable Swarms of Ferromagnetic Colloids for Enhanced Local Hyperthermia

Ferromagnetic particles (FMPs) have attracted a large amount of attention for tumor treatment in recent decades in the form of magnetic hyperthermia and thermoablation therapies. Previous research has commonly focused on the improvement of the specific loss power and the increase in the particle concentration to enhance the heating temperature during hyperthermia. Instead of magnetic hyperthermia with passive particles, here a feasible approach of using reconfigurable swarms of ferromagnetic colloidal particles is reported to realize enhanced local hyperthermia. The concentration of the particle swarm can be tuned up to 500% of the original particle concentration via reversible pattern transformation, i.e., shrinking and swelling. The FMP swarms with a controllable pattern size show their potential for directed energy delivery and offer a new strategy for realizing a highly localized heating effect using a low dose of the active FMPs.

[1]  J. Overgaard,et al.  A century with hyperthermic oncology in Scandinavia. , 1995, Acta oncologica.

[2]  C. Chien,et al.  Controllable high-speed rotation of nanowires , 2005, cond-mat/0503162.

[3]  Lixin Dong,et al.  Artificial bacterial flagella: Fabrication and magnetic control , 2009 .

[4]  Thomas E Mallouk,et al.  Schooling behavior of light-powered autonomous micromotors in water. , 2009, Angewandte Chemie.

[5]  P. Fischer,et al.  Controlled propulsion of artificial magnetic nanostructured propellers. , 2009, Nano letters.

[6]  Christos Bergeles,et al.  Characterizing the swimming properties of artificial bacterial flagella. , 2009, Nano letters.

[7]  Jake J. Abbott,et al.  How Should Microrobots Swim? , 2009 .

[8]  Ayusman Sen,et al.  Light‐Driven Titanium‐Dioxide‐Based Reversible Microfireworks and Micromotor/Micropump Systems , 2010 .

[9]  J. Fraser Stoddart,et al.  Noninvasive remote-controlled release of drug molecules in vitro using magnetic actuation of mechanized nanoparticles. , 2010, Journal of the American Chemical Society.

[10]  Andre Levchenko,et al.  Sub-Cellular Resolution Delivery of a Cytokine via Precisely Manipulated Nanowires , 2010, Nature nanotechnology.

[11]  Li Zhang,et al.  Artificial bacterial flagella for micromanipulation. , 2010, Lab on a chip.

[12]  Ioannis K. Kaliakatsos,et al.  Microrobots for minimally invasive medicine. , 2010, Annual review of biomedical engineering.

[13]  S. Vasudevan,et al.  Form, Content, and Magnetism in Iron Oxide Nanocrystals , 2011 .

[14]  Jinwoo Cheon,et al.  Exchange-coupled magnetic nanoparticles for efficient heat induction. , 2011, Nature nanotechnology.

[15]  Sadik Esener,et al.  Acoustic droplet vaporization and propulsion of perfluorocarbon-loaded microbullets for targeted tissue penetration and deformation. , 2012, Angewandte Chemie.

[16]  Wei Wang,et al.  Autonomous motion of metallic microrods propelled by ultrasound. , 2012, ACS nano.

[17]  Krzysztof K. Krawczyk,et al.  Magnetic Helical Micromachines: Fabrication, Controlled Swimming, and Cargo Transport , 2012, Advanced materials.

[18]  Eugene Shi Guang Choo,et al.  Optimization of surface coating on Fe3O4 nanoparticles for high performance magnetic hyperthermia agents , 2012 .

[19]  Marco P Monopoli,et al.  Biomolecular coronas provide the biological identity of nanosized materials. , 2012, Nature nanotechnology.

[20]  Li Zhang,et al.  Bio-inspired magnetic swimming microrobots for biomedical applications. , 2013, Nanoscale.

[21]  Soichiro Tottori,et al.  Magnetic helical micromachines. , 2013, Chemistry.

[22]  Lei Jiang,et al.  Programmable Fractal Nanostructured Interfaces for Specific Recognition and Electrochemical Release of Cancer Cells , 2013, Advanced materials.

[23]  Roberto A. Maldonado,et al.  Polymeric synthetic nanoparticles for the induction of antigen-specific immunological tolerance , 2014, Proceedings of the National Academy of Sciences.

[24]  Wei Wang,et al.  Acoustic propulsion of nanorod motors inside living cells. , 2014, Angewandte Chemie.

[25]  Wei Gao,et al.  Turning erythrocytes into functional micromotors. , 2014, ACS nano.

[26]  Gao Yang,et al.  Multifunctional “Smart” Particles Engineered from Live Immunocytes: Toward Capture and Release of Cancer Cells , 2015, Advanced materials.

[27]  A. Decho,et al.  Inorganic nanoparticles engineered to attack bacteria. , 2015, Chemical Society reviews.

[28]  Li Zhang,et al.  Bioinspired Superhydrophobic Fe3O4@Polydopamine@Ag Hybrid Nanoparticles for Liquid Marble and Oil Spill , 2015 .

[29]  Martin Pumera,et al.  Fabrication of Micro/Nanoscale Motors. , 2015, Chemical reviews.

[30]  F. Qiu,et al.  Controlled In Vivo Swimming of a Swarm of Bacteria‐Like Microrobotic Flagella , 2015, Advanced materials.

[31]  Fernando Plazaola,et al.  Fundamentals and advances in magnetic hyperthermia , 2015 .

[32]  Lei Jiang,et al.  Antibody‐Modified Reduced Graphene Oxide Films with Extreme Sensitivity to Circulating Tumor Cells , 2015, Advanced materials.

[33]  Wentao Duan,et al.  From one to many: dynamic assembly and collective behavior of self-propelled colloidal motors. , 2015, Accounts of chemical research.

[34]  Michael R Hamblin,et al.  Smart micro/nanoparticles in stimulus-responsive drug/gene delivery systems. , 2016, Chemical Society reviews.

[35]  Mingjun Xuan,et al.  Near Infrared Light-Powered Janus Mesoporous Silica Nanoparticle Motors. , 2016, Journal of the American Chemical Society.

[36]  C. Hierold,et al.  Degradable Magnetic Composites for Minimally Invasive Interventions: Device Fabrication, Targeted Drug Delivery, and Cytotoxicity Tests , 2016, Advanced materials.

[37]  Hongliang Liu,et al.  Smart Thin Hydrogel Coatings Harnessing Hydrophobicity and Topography to Capture and Release Cancer Cells. , 2016, Small.

[38]  Sumaira Ashraf,et al.  In vivo degeneration and the fate of inorganic nanoparticles. , 2016, Chemical Society reviews.

[39]  Lily Yang,et al.  Magnetic Nanoparticle Facilitated Drug Delivery for Cancer Therapy with Targeted and Image‐Guided Approaches , 2016, Advanced functional materials.

[40]  Mariana Medina-Sánchez,et al.  Medical microbots need better imaging and control , 2017, Nature.

[41]  Joseph B Tracy,et al.  Chained Iron Microparticles for Directionally Controlled Actuation of Soft Robots. , 2017, ACS applied materials & interfaces.

[42]  S Campuzano,et al.  Nano/microvehicles for efficient delivery and (bio)sensing at the cellular level , 2017, Chemical science.

[43]  Yong‐Lai Zhang,et al.  Direct Laser Writing of Superhydrophobic PDMS Elastomers for Controllable Manipulation via Marangoni Effect , 2017 .

[44]  Morteza Mahmoudi,et al.  Nanoparticle Surface Functionality Dictates Cellular and Systemic Toxicity , 2017 .

[45]  Qi Zhou,et al.  Multifunctional biohybrid magnetite microrobots for imaging-guided therapy , 2017, Science Robotics.

[46]  Tiantian Xu,et al.  On-Demand Disassembly of Paramagnetic Nanoparticle Chains for Microrobotic Cargo Delivery , 2017, IEEE Transactions on Robotics.

[47]  Jianguo Guan,et al.  Light-driven micro/nanomotors: from fundamentals to applications. , 2017, Chemical Society reviews.

[48]  A. Leshansky,et al.  Highly Efficient Freestyle Magnetic Nanoswimmer. , 2017, Nano letters.

[49]  Li Zhang,et al.  Mobile paramagnetic nanoparticle-based vortex for targeted cargo delivery in fluid , 2017, 2017 IEEE International Conference on Robotics and Automation (ICRA).

[50]  Helena Massana-Cid,et al.  Assembly and Transport of Microscopic Cargos via Reconfigurable Photoactivated Magnetic Microdockers. , 2017, Small.

[51]  Fei Peng,et al.  Micro/nanomotors towards in vivo application: cell, tissue and biofluid. , 2017, Chemical Society reviews.

[52]  Zhiguang Wu,et al.  Light-Activated Active Colloid Ribbons. , 2017, Angewandte Chemie.