Frontotemporal dementia as a neural system disease

Some brain structures atrophic in frontotemporal dementia (FTD) belong to the rostral limbic system (RLS), that regulates context-dependent behaviors after evaluation of the motivational content of stimuli. The clinical manifestations of FTD are consistent with its impairment. Aim of this study was to assess whole brain morphology in FTD using magnetic resonance imaging (MRI) and voxel-based morphometry with statistic parametric mapping (SPM99) to test the hypothesis that the RLS might be specifically targeted by FTD. Nine FTD patients and 26 healthy controls underwent high resolution 3D MRI. SPM99 performed (a) spatial normalization to a customized template, (b) segmentation, (c) smoothing, (d) voxel-by-voxel comparison of gray matter between cases and controls. P was set at 0.05 corrected for multiple comparisons. All but one regions of the RLS (the periaqueductal gray) were atrophic in FTD. At P<0.001 uncorrected also the periaqueductal gray was atrophic. Atrophy outside the RLS was confined to a few voxels in the frontal and temporal gyri. FTD might be a neural-system disease where the RLS is predominantly damaged.

[1]  C. Filley,et al.  Non-Alzheimer fronto-temporal degenerative dementia. A neurobehavioral and pathologic study. , 1994, Clinical neuropathology.

[2]  B L Miller,et al.  Patterns of brain atrophy in frontotemporal dementia and semantic dementia , 2002, Neurology.

[3]  G. Salamon,et al.  Mutism and auditory agnosia due to bilateral insular damage—Role of the insula in human communication , 1995, Neuropsychologia.

[4]  Karl J. Friston,et al.  Incorporating Prior Knowledge into Image Registration , 1997, NeuroImage.

[5]  J. Shuren,et al.  Insula and aphasia , 2004, Journal of Neurology.

[6]  B. Sahakian,et al.  Temporal lobe rating scale: application to Alzheimer's disease and frontotemporal dementia , 2001, Journal of neurology, neurosurgery, and psychiatry.

[7]  C. Olson,et al.  Functional heterogeneity in cingulate cortex: the anterior executive and posterior evaluative regions. , 1992, Cerebral cortex.

[8]  G. Frisoni,et al.  Brain atrophy in frontotemporal dementia. , 1996, Journal of neurology, neurosurgery, and psychiatry.

[9]  A. Damasio,et al.  Emotion in the perspective of an integrated nervous system 1 Published on the World Wide Web on 27 January 1998. 1 , 1998, Brain Research Reviews.

[10]  A. Damasio.  Descartes' error: emotion, reason, and the human brain. avon books , 1994 .

[11]  M. Botvinick,et al.  Conflict monitoring and cognitive control. , 2001, Psychological review.

[12]  M. Freedman,et al.  Frontotemporal lobar degeneration , 1998, Neurology.

[13]  Sasha Bozeat,et al.  Which neuropsychiatric and behavioural features distinguish frontal and temporal variants of frontotemporal dementia from Alzheimer's disease? , 2000, Journal of neurology, neurosurgery, and psychiatry.

[14]  John Patrick Aggleton,et al.  The Amygdala : a functional analysis , 2000 .

[15]  C. Rorden,et al.  Stereotaxic display of brain lesions. , 2000, Behavioural neurology.

[16]  G. Schoenbaum,et al.  Changes in Functional Connectivity in Orbitofrontal Cortex and Basolateral Amygdala during Learning and Reversal Training , 2000, The Journal of Neuroscience.

[17]  M. Laakso,et al.  Amygdaloid atrophy in frontotemporal dementia and Alzheimer's disease , 2002, Neuroscience Letters.

[18]  R. Adolphs.  Neural systems for recognizing emotion , 2002, Current Opinion in Neurobiology.

[19]  G. Frisoni,et al.  Dementia of the frontal type: neuropsychological and [99Tc]-HM-PAO SPET features. , 1995, Journal of geriatric psychiatry and neurology.

[20]  E. Rolls.  The orbitofrontal cortex and reward. , 2000, Cerebral cortex.

[21]  R. Adolphs.  The neurobiology of social cognition , 2001, Current Opinion in Neurobiology.

[22]  A. Young,et al.  Neuropsychology of fear and loathing , 2001 .

[23]  B. Everitt,et al.  Emotion and motivation: the role of the amygdala, ventral striatum, and prefrontal cortex , 2002, Neuroscience & Biobehavioral Reviews.

[24]  C. Frith,et al.  DESCARTES ERROR - EMOTION, REASON AND THE HUMAN BRAIN - DAMASIO,AR , 1995 .

[25]  L. Gustafson,et al.  Frontal lobe degeneration of non-Alzheimer type. II. Clinical picture and differential diagnosis. , 1987, Archives of gerontology and geriatrics.

[26]  M. Gallagher,et al.  The amygdala complex: multiple roles in associative learning and attention. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[27]  A. Brun,et al.  Frontal lobe degeneration of non‐Alzheimer type , 1992, Bailliere's clinical neurology.

[28]  A. Damasio.  The somatic marker hypothesis and the possible functions of the prefrontal cortex. , 1996, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[29]  T. Robbins,et al.  Impulsive Choice Induced in Rats by Lesions of the Nucleus Accumbens Core , 2001, Science.

[30]  S. Baron-Cohen,et al.  Theory of mind in patients with frontal variant frontotemporal dementia and Alzheimer's disease: theoretical and practical implications. , 2002, Brain : a journal of neurology.

[31]  R. Misslin,et al.  The defense system of fear: behavior and neurocircuitry , 2003, Neurophysiologie Clinique/Clinical Neurophysiology.

[32]  Andrew Calder,et al.  Acquired theory of mind impairments in individuals with bilateral amygdala lesions , 2003, Neuropsychologia.

[33]  M. Persinger,et al.  Shifting Gustatory Thresholds and Food Cravings during Pregnancy as Expanding Uterine-Induced Steady Potential Shifts within the Insula: An Hypothesis , 2001, Perceptual and motor skills.

[34]  Karl J. Friston,et al.  Voxel-Based Morphometry—The Methods , 2000, NeuroImage.

[35]  C. P. Hughes,et al.  A New Clinical Scale for the Staging of Dementia , 1982, British Journal of Psychiatry.

[36]  G. Bydder,et al.  Magnetic Resonance Scanning and Epilepsy , 1994, NATO ASI Series.

[37]  J. Girvin,et al.  Cardiovascular effects of human insular cortex stimulation , 1992, Neurology.

[38]  G. Schoenbaum,et al.  Neural Encoding in Ventral Striatum during Olfactory Discrimination Learning , 2003, Neuron.

[39]  B. Vogt,et al.  Contributions of anterior cingulate cortex to behaviour. , 1995, Brain : a journal of neurology.

[40]  R. Levy,et al.  Neuropathological Correlates of Behavioural Disturbance in Confirmed Alzheimer's Disease , 1993, British Journal of Psychiatry.

[41]  C. DeCarli,et al.  The role of neuroimaging in dementia. , 2001, Clinics in geriatric medicine.

[42]  G. A. Clark,et al.  Emotional Learning: Fear and loathing in the amygdala , 1995, Current Biology.

[43]  J. Baron,et al.  In Vivo Mapping of Gray Matter Loss with Voxel-Based Morphometry in Mild Alzheimer's Disease , 2001, NeuroImage.

[44]  Alan C. Evans,et al.  An MRI-Based Probabilistic Atlas of Neuroanatomy , 1994 .