The Role of Oat Nutrients in the Immune System: A Narrative Review

Abstracts Optimal nutrition is the foundation for the development and maintenance of a healthy immune system. An optimal supply of nutrients is required for biosynthesis of immune factors and immune cell proliferation. Nutrient deficiency/inadequacy and hidden hunger, which manifests as depleted nutrients reserves, increase the risk of infectious diseases and aggravate disease severity. Therefore, an adequate and balanced diet containing an abundant diversity of foods, nutrients, and non-nutrient chemicals is paramount for an optimal immune defense against infectious diseases, including cold/flu and non-communicable diseases. Some nutrients and foods play a larger role than others in the support of the immune system. Oats are a nutritious whole grain and contain several immunomodulating nutrients. In this narrative review, we discuss the contribution of oat nutrients, including dietary fiber (β-glucans), copper, iron, selenium, and zinc, polyphenolics (ferulic acid and avenanthramides), and proteins (glutamine) in optimizing the innate and adaptive immune system’s response to infections directly by modulating the innate and adaptive immunity and indirectly by eliciting changes in the gut microbiota and related metabolites.

[1]  N. Xia,et al.  Involvement of Gut Microbiota, Microbial Metabolites and Interaction with Polyphenol in Host Immunometabolism , 2020, Nutrients.

[2]  S. Yusuf,et al.  White Rice Intake and Incident Diabetes: A Study of 132,373 Participants in 21 Countries , 2020, Diabetes Care.

[3]  A. Carr,et al.  Reply to “Overstated Claims of Efficacy and Safety. Comment On: Optimal Nutritional Status for a Well-Functioning Immune System Is an Important Factor to Protect against Viral Infections. Nutrients 2020, 12, 1181” , 2020, Nutrients.

[4]  Bing Zhang,et al.  Intra-Individual Double Burden of Malnutrition among Adults in China: Evidence from the China Health and Nutrition Survey 2015 , 2020, Nutrients.

[5]  A. Alkhatib.  Antiviral Functional Foods and Exercise Lifestyle Prevention of Coronavirus , 2020, Nutrients.

[6]  M. Laus,et al.  Comprehensive overview of the quality of plant‐ And animal‐sourced proteins based on the digestible indispensable amino acid score , 2020, Food science & nutrition.

[7]  H. Kwon,et al.  Nutritional status of patients with coronavirus disease 2019 (COVID-19) , 2020, International Journal of Infectious Diseases.

[8]  H. Polonini,et al.  Postulated Adjuvant Therapeutic Strategies for COVID-19 , 2020, Journal of personalized medicine.

[9]  L. Ji,et al.  Avenanthramide supplementation reduces eccentric exercise-induced inflammation in young men and women , 2020, Journal of the International Society of Sports Nutrition.

[10]  Zoher F. Kapasi,et al.  The immune system , 2020, Anaesthesia & Intensive Care Medicine.

[11]  W. Fávaro,et al.  Vitamin D, Zinc and Glutamine: Synergistic Action with OncoTherad Immunomodulator in Interferon Signaling and COVID-19 , 2020 .

[12]  N. Lowe,et al.  Zinc deficiency in low- and middle-income countries: prevalence and approaches for mitigation. , 2020, Journal of human nutrition and dietetics : the official journal of the British Dietetic Association.

[13]  C. Lindqvist,et al.  Effects of Dietary Fibres on Acute Indomethacin-Induced Intestinal Hyperpermeability in the Elderly: A Randomised Placebo Controlled Parallel Clinical Trial , 2020, Nutrients.

[14]  Nathaniel J. S. Ashby.  Impact of the COVID‐19 Pandemic on Unhealthy Eating in Populations with Obesity , 2020, Obesity.

[15]  H. Kitazawa,et al.  The Modulation of Mucosal Antiviral Immunity by Immunobiotics: Could They Offer Any Benefit in the SARS-CoV-2 Pandemic? , 2020, Frontiers in Physiology.

[16]  E. Uribe-Querol,et al.  Phagocytosis: Our Current Understanding of a Universal Biological Process , 2020, Frontiers in Immunology.

[17]  R. Eri,et al.  Microbiota Modulating Nutritional Approaches to Countering the Effects of Viral Respiratory Infections Including SARS-CoV-2 through Promoting Metabolic and Immune Fitness with Probiotics and Plant Bioactives , 2020, Microorganisms.

[18]  L. Barrea,et al.  Eating habits and lifestyle changes during COVID-19 lockdown: an Italian survey , 2020, Journal of Translational Medicine.

[19]  Alex Brito,et al.  Strengthening the Immune System and Reducing Inflammation and Oxidative Stress through Diet and Nutrition: Considerations during the COVID-19 Crisis , 2020, Nutrients.

[20]  R. M. Barrientos,et al.  The impact of nutrition on COVID-19 susceptibility and long-term consequences , 2020, Brain, Behavior, and Immunity.

[21]  Pengfei Jiang,et al.  Oat-Derived β-Glucans Induced Trained Immunity Through Metabolic Reprogramming , 2020, Inflammation.

[22]  V. Telle-Hansen,et al.  Dietary Fiber, Gut Microbiota, and Metabolic Regulation—Current Status in Human Randomized Trials , 2020, Nutrients.

[23]  J. DiNicolantonio,et al.  Nutraceuticals have potential for boosting the type 1 interferon response to RNA viruses including influenza and coronavirus , 2020, Progress in Cardiovascular Diseases.

[24]  Zhisheng Wang,et al.  Glutamine Metabolism and Its Role in Immunity, a Comprehensive Review , 2020, Animals : an open access journal from MDPI.

[25]  M. Bucciantini,et al.  Healthy Effects of Plant Polyphenols: Molecular Mechanisms , 2020, International journal of molecular sciences.

[26]  K. Dodd,et al.  Total Usual Micronutrient Intakes Compared to the Dietary Reference Intakes among U.S. Adults by Food Security Status , 2019, Nutrients.

[27]  B. Gu,et al.  The impact of dietary fiber and probiotics in infectious diseases. , 2019, Microbial pathogenesis.

[28]  M. Weickert,et al.  Obesity Does Not Modulate the Glycometabolic Benefit of Insoluble Cereal Fibre in Subjects with Prediabetes—A Stratified Post Hoc Analysis of the Optimal Fibre Trial (OptiFiT) , 2019, Nutrients.

[29]  E. Riboli,et al.  Plasma polyphenols associated with lower high-sensitivity C-reactive protein concentrations: a cross-sectional study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort , 2019, British Journal of Nutrition.

[30]  P. Shewry,et al.  Composition and content of phenolic acids and avenanthramides in commercial oat products: Are oats an important polyphenol source for consumers? , 2019, Food chemistry: X.

[31]  A. Kurilich,et al.  Oat porridge consumption alleviates markers of inflammation and oxidative stress in hypercholesterolemic adults. , 2019, Asia Pacific journal of clinical nutrition.

[32]  Jing Yang,et al.  Sodium ferulate protects against influenza virus infection by activation of the TLR7/9-MyD88-IRF7 signaling pathway and inhibition of the NF-κB signaling pathway. , 2019, Biochemical and biophysical research communications.

[33]  R. Clark,et al.  Dietary Cellulose Supplementation Modulates the Immune Response in a Murine Endotoxemia Model , 2019, Shock.

[34]  M. Wiese,et al.  Oat bran, but not its isolated bioactive β-glucans or polyphenols, have a bifidogenic effect in an in vitro fermentation model of the gut microbiota. , 2019, The British journal of nutrition.

[35]  Yasukiyo Yoshioka,et al.  Role of Intestinal Microbiota in the Bioavailability and Physiological Functions of Dietary Polyphenols , 2019, Molecules.

[36]  Cheat Sheet.  Selenium , 2018, Reactions Weekly.

[37]  R. Curi,et al.  Glutamine: Metabolism and Immune Function, Supplementation and Clinical Translation , 2018, Nutrients.

[38]  J. Blumberg,et al.  Hidden Hunger: Solutions for America’s Aging Populations , 2018, Nutrients.

[39]  Peter R Hoffmann,et al.  Selenium, Selenoproteins, and Immunity , 2018, Nutrients.

[40]  R. Horst,et al.  Role of gut microbiota in chronic low‐grade inflammation as potential driver for atherosclerotic cardiovascular disease: a systematic review of human studies , 2018, Obesity reviews : an official journal of the International Association for the Study of Obesity.

[41]  S. Tuntipopipat,et al.  Ferulic Acid Supplementation Improves Lipid Profiles, Oxidative Stress, and Inflammatory Status in Hyperlipidemic Subjects: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial , 2018, Nutrients.

[42]  M. Weickert,et al.  Fibre supplementation for the prevention of type 2 diabetes and improvement of glucose metabolism: the randomised controlled Optimal Fibre Trial (OptiFiT) , 2018, Diabetologia.

[43]  M. Totsuka,et al.  Immunomodulation by food: impact on gut immunity and immune cell function , 2018, Bioscience, biotechnology, and biochemistry.

[44]  J. Slavin,et al.  Health Effects and Sources of Prebiotic Dietary Fiber , 2018, Current developments in nutrition.

[45]  Jui-Ming Liu,et al.  The influence of prebiotic or probiotic supplementation on antibody titers after influenza vaccination: a systematic review and meta-analysis of randomized controlled trials , 2018, Drug design, development and therapy.

[46]  S. Zhang,et al.  Pretreatment of ferulic acid attenuates inflammation and oxidative stress in a rat model of lipopolysaccharide-induced acute respiratory distress syndrome , 2018, International journal of immunopathology and pharmacology.

[47]  J. Breda,et al.  Adult Nutrient Intakes from Current National Dietary Surveys of European Populations , 2017, Nutrients.

[48]  Xiaoping Yu,et al.  Structure Properties and Mechanisms of Action of Naturally Originated Phenolic Acids and Their Derivatives against Human Viral Infections. , 2017, Current medicinal chemistry.

[49]  V. Burley,et al.  Dietary fibre in Europe: current state of knowledge on definitions, sources, recommendations, intakes and relationships to health , 2017, Nutrition Research Reviews.

[50]  M. McRae.  Therapeutic Benefits of Glutamine: An Umbrella Review of Meta‐Analyses , 2017, Biomedical reports.

[51]  H. Rasmussen,et al.  Substituting whole grains for refined grains in a 6-wk randomized trial has a modest effect on gut microbiota and immune and inflammatory markers of healthy adults. , 2017, The American journal of clinical nutrition.

[52]  P. Bermejo-Barrera,et al.  In vivo and in vitro testing for selenium and selenium compounds bioavailability assessment in foodstuff , 2017, Critical reviews in food science and nutrition.

[53]  H. Holscher.  Dietary fiber and prebiotics and the gastrointestinal microbiota , 2017, Gut microbes.

[54]  P. Hugenholtz,et al.  Emerging pathogenic links between microbiota and the gut–lung axis , 2016, Nature Reviews Microbiology.

[55]  S. Rath,et al.  Identification of Suitable Natural Inhibitor against Influenza A (H1N1) Neuraminidase Protein by Molecular Docking , 2016, Genomics & informatics.

[56]  T. Bohn,et al.  Bioactivity of Polyphenols: Preventive and Adjuvant Strategies toward Reducing Inflammatory Bowel Diseases—Promises, Perspectives, and Pitfalls , 2016, Oxidative medicine and cellular longevity.

[57]  J. Berkley,et al.  Immune Dysfunction as a Cause and Consequence of Malnutrition , 2016, Trends in immunology.

[58]  O. Kennedy,et al.  Effects of increased wholegrain consumption on immune and inflammatory markers in healthy low habitual wholegrain consumers , 2016, European Journal of Nutrition.

[59]  P. White.  Selenium accumulation by plants. , 2015, Annals of botany.

[60]  W. Ahmad,et al.  Plant-derived immunomodulators: an insight on their preclinical evaluation and clinical trials , 2015, Front. Plant Sci..

[61]  P. Calder,et al.  Effect of Lactobacillus paracasei subsp. paracasei, L. casei 431 on immune response to influenza vaccination and upper respiratory tract infections in healthy adult volunteers: a randomized, double-blind, placebo-controlled, parallel-group study. , 2015, The American journal of clinical nutrition.

[62]  Nand K. Singh,et al.  Reduction of phytic acid and enhancement of bioavailable micronutrients in food grains , 2015, Journal of Food Science and Technology.

[63]  D. Stewart,et al.  Oat agriculture, cultivation and breeding targets: implications for human nutrition and health , 2014, British Journal of Nutrition.

[64]  D. Varley,et al.  Effectiveness of probiotics on the duration of illness in healthy children and adults who develop common acute respiratory infectious conditions: a systematic review and meta-analysis , 2014, British Journal of Nutrition.

[65]  J. Gruenwald,et al.  Immune-modulatory effects of dietary Yeast Beta-1,3/1,6-D-glucan , 2014, Nutrition Journal.

[66]  C. Kang,et al.  Avenanthramide supplementation attenuates exercise-induced inflammation in postmenopausal women , 2014, Nutrition Journal.

[67]  Robert C. Brown,et al.  Nutritional comparison of oats and other commonly consumed whole grains. , 2013 .

[68]  F. Tinahones,et al.  Benefits of polyphenols on gut microbiota and implications in human health. , 2013, The Journal of nutritional biochemistry.

[69]  Rajinder Singh,et al.  Avena sativa (Oat), A Potential Neutraceutical and Therapeutic Agent: An Overview , 2013, Critical reviews in food science and nutrition.

[70]  J. Cavaillon,et al.  Natural Killer (NK) Cells in Antibacterial Innate Immunity: Angels or Devils? , 2012, Molecular medicine.

[71]  M. Neuhouser,et al.  A low-glycemic load diet reduces serum C-reactive protein and modestly increases adiponectin in overweight and obese adults. , 2012, The Journal of nutrition.

[72]  X. Tang,et al.  Ferulic acid induces heme oxygenase-1 via activation of ERK and Nrf2. , 2011, Drug discoveries & therapeutics.

[73]  Yikyung Park,et al.  Dietary fiber intake and mortality in the NIH-AARP diet and health study. , 2011, Archives of internal medicine.

[74]  Lin Yan,et al.  Selenium bioavailability from naturally produced high-selenium peas and oats in selenium-deficient rats. , 2011, Journal of agricultural and food chemistry.

[75]  Leonor Rodríguez,et al.  Malnutrition and Gastrointestinal and Respiratory Infections in Children: A Public Health Problem , 2011, International journal of environmental research and public health.

[76]  S. Willich,et al.  Reduction of common cold symptoms by encapsulated juice powder concentrate of fruits and vegetables: a randomised, double-blind, placebo-controlled trial , 2010, British Journal of Nutrition.

[77]  W. Paul,et al.  Differentiation of effector CD4 T cell populations (*). , 2010, Annual review of immunology.

[78]  J. Jerling,et al.  The effects of dietary fibre on C-reactive protein, an inflammation marker predicting cardiovascular disease , 2009, European Journal of Clinical Nutrition.

[79]  R. Mensink,et al.  Consumption of oat beta-glucan with or without plant stanols did not influence inflammatory markers in hypercholesterolemic subjects. , 2009, Molecular nutrition & food research.

[80]  J. Davis,et al.  Beta-glucan, immune function, and upper respiratory tract infections in athletes. , 2008, Medicine and science in sports and exercise.

[81]  P. Katona,et al.  The interaction between nutrition and infection. , 2008, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[82]  J. Davis,et al.  Benefits of oat beta-glucan on respiratory infection following exercise stress: role of lung macrophages. , 2008, American journal of physiology. Regulatory, integrative and comparative physiology.

[83]  Peter Libby,et al.  Inflammatory mechanisms: the molecular basis of inflammation and disease. , 2007, Nutrition reviews.

[84]  C. Ehrhardt,et al.  CYSTUS052, a polyphenol-rich plant extract, exerts anti-influenza virus activity in mice. , 2007, Antiviral research.

[85]  Silvia Maggini,et al.  Contribution of Selected Vitamins and Trace Elements to Immune Function , 2007, Annals of Nutrition and Metabolism.

[86]  J. González‐Gallego,et al.  Anti-inflammatory properties of dietary flavonoids. , 2007, Nutricion hospitalaria.

[87]  I. Chapman.  Nutritional disorders in the elderly. , 2006, The Medical clinics of North America.

[88]  P. Calder,et al.  Markers to measure immunomodulation in human nutrition intervention studies , 2005, British Journal of Nutrition.

[89]  R. Stoltzfus.  Iron Deficiency: Global Prevalence and Consequences , 2003, Food and nutrition bulletin.

[90]  Denis Muller,et al.  Dietary patterns and changes in body mass index and waist circumference in adults. , 2003, The American journal of clinical nutrition.

[91]  J. Cook,et al.  Degradation of phytic acid in cereal porridges improves iron absorption by human subjects. , 2003, The American journal of clinical nutrition.

[92]  P. Calder,et al.  The immune system: a target for functional foods? , 2002, The British journal of nutrition.

[93]  S. Blum,et al.  Selenium deficiency increases the pathology of an influenza virus infection , 2001, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[94]  G. Combs,et al.  Selenium in global food systems , 2001, British Journal of Nutrition.

[95]  A. Grabrucker,et al.  Zinc deficiency , 2000, Archives of disease in childhood.

[96]  S. Romagnani,et al.  T-cell subsets (Th1 versus Th2). , 2000, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

[97]  J. Knight.  Review: Free radicals, antioxidants, and the immune system. , 2000, Annals of clinical and laboratory science.

[98]  H. Payette,et al.  Relationship between the response to influenza vaccination and the nutritional status in institutionalized elderly subjects. , 1999, The journals of gerontology. Series A, Biological sciences and medical sciences.

[99]  P. Trumbo,et al.  Dietary reference intakes: vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc. , 1998, Journal of the American Dietetic Association.

[100]  A. Sandberg,et al.  Improved zinc and iron absorption from breakfast meals containing malted oats with reduced phytate content , 1996, British Journal of Nutrition.

[101]  B. Hannigan.  Diet and immune function. , 1994, British journal of biomedical science.

[102]  S. Bingham,et al.  Dietary fibre (non‐starch polysaccharides) in cereal products , 1989 .

[103]  E. Middleton,et al.  Antiviral effect of flavonoids on human viruses , 1985, Journal of medical virology.

[104]  Defa Li,et al.  Butyrate: A Double-Edged Sword for Health? , 2018, Advances in nutrition.

[105]  M. Ferruzzi,et al.  Oats-From Farm to Fork. , 2016, Advances in food and nutrition research.

[106]  M. Fernández,et al.  Impact of Obesity and Metabolic Syndrome on Immunity. , 2016, Advances in nutrition.

[107]  H. Steinbrenner,et al.  Dietary selenium in adjuvant therapy of viral and bacterial infections. , 2015, Advances in nutrition.

[108]  J. Jones.  Dietary fiber future directions: integrating new definitions and findings to inform nutrition research and communication. , 2013, Advances in nutrition.

[109]  Yvonne Sun,et al.  Regulation of bacterial pathogenesis by intestinal short-chain Fatty acids. , 2013, Advances in applied microbiology.

[110]  R. Welch,et al.  Nutrient composition and nutritional quality of oats and comparisons with other cereals. , 2011 .

[111]  Joseph M. Awika,et al.  Major Cereal Grains Production and Use around the World , 2011 .

[112]  K. P. Murphy,et al.  Janeway's immunobiology , 2007 .

[113]  J. Didziapetriene,et al.  Effects of beta-glucans on the immune system. , 2007, Medicina.

[114]  P. Calder.  Branched-chain amino acids and immunity. , 2006, The Journal of nutrition.

[115]  J. Davis,et al.  Effects of oat beta-glucan on innate immunity and infection after exercise stress. , 2004, Medicine and science in sports and exercise.

[116]  C. Yun,et al.  Beta-glucan, extracted from oat, enhances disease resistance against bacterial and parasitic infections. , 2003, FEMS immunology and medical microbiology.

[117]  Joint Fao,et al.  Human vitamin and mineral requirements , 2002 .

[118]  B. Spellberg,et al.  Type 1/Type 2 immunity in infectious diseases. , 2001, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[119]  R. Chandra,et al.  Obesity, overnutrition and the immune system , 2001 .

[120]  M. Eaman.  Immune system. , 2000, Nursing standard (Royal College of Nursing (Great Britain) : 1987).