Antibody Formation in Myelomatosis

In recent years several workers have submitted evidence suggesting that plasma cells are the site of antibody formation (e.g., Fagraeus, 1948). In the present work antibody production, as indicated by circulating levels of staphylococcal a-antitoxin and antistreptolysin 0, has been studied in patients with myelomatosis, a disease characterized by disordered growth of plasma cells. In addition to cases of myelomatosis, patients with hyperglobulinaemia due to other causes were examined serologically, and both series were compared with a group of normal persons.