Origem da hipercolesterolemia na síndrome nefrótica experimental

Foi efetuado o balanco continuo de esteroides (15 a 20 dias) em 16 ratos nefroticos (N) e 8 controles (C). Em toda a experiencia (duracao de aproximadamente 2 meses), os animais ingeriram quantidades rigorosamente iguais de uma dieta balanceada e isenta de esteroides e, foi medida regularmente sua proteinuria para avaliacao do grau de nefrose. Tambem foram medidos o colesterol e albumina no plasma. Apos o periodo experimental, os ratos foram exsanguinados. Figado, carcassa (excluidos o intestino e o sistema nervoso central) e fezes foram analisadas por cronatografia gas-liquido de esteroides apos hidrolise alcalina, extracao e cromatografia camada fina das amostras. As perdas de material foram corrigidas pela edicao de colesterol e acido eolico radioativos as amostras no inicio do processamento metodologico. Os resultados mostram que a excrecao feudal em N permanecer igual a de C mas que houve um real acrescimo no conteudo em colesterol de sangue, figado e carcassa indicando ter havido uma sintese aumentada em N. A possivel relacao entre o metabolismo proteico e sintese hepatica de colesterol na sindrome nefrotica e discutida.

[1]  J. Dich,et al.  Effect of albumin concentration and colloid osmotic pressure on albumin synthesis in the perfused rat liver. , 1973, Acta physiologica Scandinavica.

[2]  A. Huberman.  The in vitro effect of colloid osmotic pressure on albumin biosynthesis in normal rat liver. , 1973, Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion.

[3]  E. Shafrir,et al.  Hepatic metabolic pathways and hormonal status in experimental nephrotic syndrome. , 1972, Israel journal of medical sciences.

[4]  T. Miettinen.  Detection of changes in human cholesterol metabolism. , 1970, Annals of clinical research.

[5]  Matsuda Ichiro,et al.  Lipoprotein lipase in clinical and experimental nephrosis. , 1970 .

[6]  P. Wong,et al.  Plasma lipoprotein lipase in children with idiopathic nephrotic syndrome. , 1969, Pediatrics.

[7]  J. Holloszy,et al.  Effects of weight changes produced by exercise, food restriction, or overeating on body composition. , 1969, The Journal of clinical investigation.

[8]  P. Nestel,et al.  Studies on the turnover of triglyceride and esterified cholesterol in subjects with the nephrotic syndrome. , 1968, The Journal of clinical investigation.

[9]  J. Katz,et al.  Albumin synthesis in perfused liver of normal and nephrotic rats. , 1967, The American journal of physiology.

[10]  S. Grundy,et al.  QUANTITATIVE ISOLATION AND GAS--LIQUID CHROMATOGRAPHIC ANALYSIS OF TOTAL FECAL BILE ACIDS. , 1965, Journal of lipid research.

[11]  S. Grundy,et al.  QUANTITATIVE ISOLATION AND GAS--LIQUID CHROMATOGRAPHIC ANALYSIS OF TOTAL DIETARY AND FECAL NEUTRAL STEROIDS. , 1965, Journal of lipid research.

[12]  D. Drabkin,et al.  Amino acid mobilization in plasma protein biosynthesis in experimental nephrosis. , 1962, Metabolism: clinical and experimental.

[13]  H. Goodman,et al.  Amendment history : Correction ( May 1961 ) EFFECTS OF INFUSIONS OF SERUM ALBUMIN ON SERUM LIPIDS AND LIPOPROTEINS IN NEPHROSIS , 2018 .

[14]  U. Dubach,et al.  Negative Feedback Mechanism of Cholesterol Synthesis in Experimental Nephrosis.∗ , 1961, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[15]  R. Searcy,et al.  Rapid ultramicro estimation of serum total cholesterol. , 1960, Journal of lipid research.

[16]  R. Havel,et al.  Serum lipid and lipoprotein alterations in nephrosis. , 1960, The Journal of clinical investigation.

[17]  N. Kalant,et al.  Thyroid function in experimental nephrotic syndrome. , 1959, Endocrinology.

[18]  R. Rosenman,et al.  Effects of Altered Thyroid Function on Plasma Lipids of Experimentally Nephrotic Rats.∗ , 1958, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[19]  D. Drabkin,et al.  Metabolic channeling in experimental nephrosis. V. Lipide metabolism in the early stages of the disease. , 1958, The Journal of biological chemistry.

[20]  M. Friedman,et al.  Lipid and cholesterol content of hepatic lymph in experimental nephrosis. , 1957, The American journal of physiology.

[21]  M. Friedman,et al.  In vivo studies of the role of albumin in endogenous and heparin-activated lipemia-clearing in nephrotic rats. , 1957, The Journal of clinical investigation.

[22]  D. Hackel,et al.  Hepatic and extrahepatic depot lipids in rats with experimental nephrotic hyperlipemia. , 1957, Metabolism: clinical and experimental.

[23]  W. Heymann,et al.  Effect of Ethionine on Blood and Depot Lipids in Experimental Nephrotic Hyperlipemia.∗ , 1956, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[24]  M. Friedman,et al.  The distribution of cholesterol and total lipids in the nephrotic rat. , 1955, The Journal of clinical investigation.

[25]  D. Drabkin,et al.  Metabolic channeling in experimental nephrosis. II. Lipide metabolism. , 1955, The Journal of biological chemistry.

[26]  M. Friedman,et al.  Intestinal Absorption of Cholesterol by the Nephrotic Rat , 1954, Circulation research.

[27]  D. S. Riggs,et al.  Thyroid function in nephrosis. , 1952, The Journal of clinical investigation.

[28]  D. Fredrickson,et al.  LIPOLYTIC ACTIVITY OF POST-HEPARIN PLASMA IN HYPERGLYCERIDEMIA. , 1963, Journal of lipid research.

[29]  C. Malmendier.  Tissue distribution of C-14 after the intravenous injection of labeled free fatty acids and chylomicrons in nephrotic rats. , 1962, The Journal of clinical investigation.