论文信息 - Did a Single Amino Acid Change Make Ebola Virus More Virulent?

Did a Single Amino Acid Change Make Ebola Virus More Virulent?

A mutation in the Ebola virus glycoprotein arose early during the 2013-2016 epidemic and dominated the viral population. Two studies by Diehl et al. and Urbanowicz et al. now reveal that this mutation is associated with higher infectivity to human cells, representing the clearest example of Ebola's functional adaptation to human hosts.

Trevor Bedford | T. Bedford | Harmit S. Malik

[1] Rachel S. G. Sealfon,et al. Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak , 2014, Science.

[2] Edward C. Holmes,et al. Human Adaptation of Ebola Virus during the West African Outbreak , 2016, Cell.

[3] G. Gao,et al. Ebola Viral Glycoprotein Bound to Its Endosomal Receptor Niemann-Pick C1 , 2016, Cell.

[4] Guang-Wu Chen,et al. Genomic Signatures of Human versus Avian Influenza A Viruses , 2006, Emerging infectious diseases.

[5] Claire Marie Filone,et al. Small molecule inhibitors reveal Niemann-Pick C1 is essential for ebolavirus infection , 2011, Nature.

[6] K. Chandran,et al. Host-Primed Ebola Virus GP Exposes a Hydrophobic NPC1 Receptor-Binding Pocket, Revealing a Target for Broadly Neutralizing Antibodies , 2016, mBio.

[7] J. Dye,et al. Ebola virus entry requires the cholesterol transporter Niemann-Pick C1 , 2011, Nature.

[8] Pardis C. Sabeti,et al. Ebola Virus Glycoprotein with Increased Infectivity Dominated the 2013–2016 Epidemic , 2016, Cell.

[9] G. Gao,et al. Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol Transfer and Ebola Infection , 2016, Cell.