Feasibility and suitability of targeting young gay men for HIV vaccine efficacy trials.

We evaluated factors affecting the feasibility of including young high-risk HIV-negative gay and bisexual men in preventive HIV vaccine trials using data from the U.S. Centers for Disease Control and Prevention Collaborative HIV Seroincidence Study. Of 2189 men enrolled in this study, 17% were <25 years of age. HIV seroincidence was 4.2/100 person-years (95% confidence interval [CI], 2.6-7.0) in young men compared with 2.0/100 person-years (95% CI, 1.4-2.6) for older men. Compared with men 25 and older, young men were more likely to report several high-risk behaviors, to perceive themselves to be at risk for HIV infection, and to report that their risk behavior might be increased by participation in an HIV vaccine trial. The majority of both young men (69%) and older men (74%) expressed willingness in participate in HIV vaccine trials. Young men were less likely to answer questions about vaccine concepts correctly and were more likely to be lost to follow-up. Young gay and bisexual men are important candidates for future HIV vaccine trials, but they may need targeted approaches to recruitment, retention, education about trial concepts prior to enrollment, and behavioral interventions during the trial.

[1]  P. Heagerty,et al.  Readiness of high‐risk populations in the HIV Network for Prevention Trials to participate in HIV vaccine efficacy trials in the United States , 1998, AIDS.

[2]  S. Buchbinder,et al.  Feasibility of human immunodeficiency virus vaccine trials in homosexual men in the United States: risk behavior, seroincidence, and willingness to participate. , 1996, The Journal of infectious diseases.

[3]  B. Koblin,et al.  The feasibility of HIV‐1 vaccine efficacy trials among gay/bisexual men in New York City: Project ACHIEVE , 1996, AIDS.

[4]  G. Woody,et al.  Will preventive HIV vaccine efficacy trials be possible with female injection drug users? , 1995, Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association.

[5]  I. Meyer,et al.  Patterns of sexual behavior and risk taking among young New York City gay men. , 1995, AIDS education and prevention : official publication of the International Society for AIDS Education.

[6]  H. Sheppard,et al.  HIV infection in homosexual and bisexual men 18 to 29 years of age: the San Francisco Young Men's Health Study. , 1994, American journal of public health.

[7]  R. Janssen,et al.  Seroprevalence of HIV and risk behaviors among young homosexual and bisexual men. The San Francisco/Berkeley Young Men's Survey. , 1994, JAMA.

[8]  J. Catania,et al.  A comparison of younger and older gay men's HIV risk-taking behaviors: the Communication Technologies 1989 Cross-Sectional Survey. , 1992, Journal of acquired immune deficiency syndromes.

[9]  C. Boyer,et al.  AIDS risk and prevention among adolescents. , 1991, Social science & medicine.

[10]  R. Hayes,et al.  Epidemiological and public health considerations in the design of HIV vaccine trials. , 1991, AIDS.

[11]  T. Coates,et al.  High HIV risk-taking among young gay men. , 1990, AIDS.

[12]  T. Coates,et al.  Maintenance of safer sexual behaviors and predictors of risky sex: the San Francisco Men's Health Study. , 1990, American journal of public health.

[13]  K Y Liang,et al.  Longitudinal data analysis for discrete and continuous outcomes. , 1986, Biometrics.