The mTOR inhibitor, everolimus (RAD001), overcomes resistance to imatinib in quiescent Ph-positive acute lymphoblastic leukemia cells
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T. Naoe | H. Kiyoi | F. Hayakawa | D. Goff | K. Sugimoto | A. Abe | Y. Kuwatsuka | Y. Minami | Y. Miyata | K. Sugimoto | M. Minami
[1] B. Leber,et al. The human stem cell hierarchy is defined by a functional dependence on Mcl-1 for self-renewal capacity. , 2010, Blood.
[2] J. Tamburini,et al. Perspectives on inhibiting mTOR as a future treatment strategy for hematological malignancies , 2010, Leukemia.
[3] T. Naoe,et al. Irrespective of CD34 expression, lineage‐committed cell fraction reconstitutes and re‐establishes transformed Philadelphia chromosome‐positive leukemia in NOD / SCID / IL‐2Rγc−/− mice , 2010, Cancer science.
[4] Jing Chen,et al. Effective and selective targeting of leukemia cells using a TORC1/2 kinase inhibitor , 2010, Nature Medicine.
[5] T. Clackson,et al. AP24534, a pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits the T315I mutant and overcomes mutation-based resistance. , 2009, Cancer cell.
[6] H. Kantarjian,et al. Imatinib and beyond—exploring the full potential of targeted therapy for CML , 2009, Nature Reviews Clinical Oncology.
[7] P. Majumder,et al. Targeting the Notch1 and mTOR pathways in a mouse T-ALL model. , 2009, Blood.
[8] Funda Meric-Bernstam,et al. Targeting the mTOR signaling network for cancer therapy. , 2009, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[9] M. Dyer,et al. Targeting autophagy potentiates tyrosine kinase inhibitor-induced cell death in Philadelphia chromosome-positive cells, including primary CML stem cells. , 2009, The Journal of clinical investigation.
[10] P. Kearns,et al. Expression of CD133 on leukemia-initiating cells in childhood ALL. , 2009, Blood.
[11] R. Crazzolara,et al. Potentiating effects of RAD001 (Everolimus) on vincristine therapy in childhood acute lymphoblastic leukemia. , 2009, Blood.
[12] T. Naoe,et al. BCR-ABL-transformed GMP as myeloid leukemic stem cells , 2008, Proceedings of the National Academy of Sciences.
[13] David E. Housman,et al. mTORC1 promotes survival through translational control of Mcl-1 , 2008, Proceedings of the National Academy of Sciences.
[14] J. Okamura,et al. CD34+CD38+CD19+ as well as CD34+CD38−CD19+ cells are leukemia-initiating cells with self-renewal capacity in human B-precursor ALL , 2008, Leukemia.
[15] T. Enver,et al. Initiating and Cancer-Propagating Cells in TEL-AML1-Associated Childhood Leukemia , 2008, Science.
[16] R. V. van Etten,et al. Right on target: eradicating leukemic stem cells. , 2007, Trends in molecular medicine.
[17] Satoshi Tanaka,et al. Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region , 2007, Nature Biotechnology.
[18] Y. Pan,et al. Increased phosphorylation of p70 S6 kinase is associated with HPV16 infection in cervical cancer and esophageal cancer , 2007, British Journal of Cancer.
[19] C. Jordan. The leukemic stem cell. , 2007, Best practice & research. Clinical haematology.
[20] T. Naoe,et al. Establishment of a Stroma-Dependent Human Acute Myelomonocytic Leukemia Cell Line, NAMO-2, with FLT3 Tandem Duplication , 2006, International journal of hematology.
[21] Ingo Roeder,et al. Dynamic modeling of imatinib-treated chronic myeloid leukemia: functional insights and clinical implications , 2006, Nature Medicine.
[22] M. Konopleva,et al. Phase I/II Study of the Mammalian Target of Rapamycin Inhibitor Everolimus (RAD001) in Patients with Relapsed or Refractory Hematologic Malignancies , 2006, Clinical Cancer Research.
[23] G. Lenz,et al. Alternating versus concurrent schedules of imatinib and chemotherapy as front-line therapy for Philadelphia-positive acute lymphoblastic leukemia (Ph^+ALL) , 2006 .
[24] S. Morrison,et al. Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells , 2006, Nature.
[25] M. Hall,et al. TOR Signaling in Growth and Metabolism , 2006, Cell.
[26] B. Druker,et al. Targeted CML therapy: controlling drug resistance, seeking cure. , 2006, Current opinion in genetics & development.
[27] M. Carroll,et al. mTOR regulates cell survival after etoposide treatment in primary AML cells. , 2005, Blood.
[28] P. Codogno,et al. Autophagy and signaling: their role in cell survival and cell death , 2005, Cell Death and Differentiation.
[29] Martin A. Nowak,et al. Dynamics of chronic myeloid leukaemia , 2005, Nature.
[30] S. Forman,et al. Nonproliferating CML CD34+ progenitors are resistant to apoptosis induced by a wide range of proapoptotic stimuli , 2005, Leukemia.
[31] D. Guertin,et al. Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex , 2005, Science.
[32] D. Neuberg,et al. Combination of rapamycin and protein tyrosine kinase (PTK) inhibitors for the treatment of leukemias caused by oncogenic PTKs. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[33] T. Naoe,et al. Different antiapoptotic pathways between wild-type and mutated FLT3: insights into therapeutic targets in leukemia. , 2003, Blood.
[34] H. Saito,et al. Selective apoptosis of tandemly duplicated FLT3-transformed leukemia cells by Hsp90 inhibitors , 2002, Leukemia.
[35] C. Eaves,et al. Isolation of a highly quiescent subpopulation of primitive leukemic cells in chronic myeloid leukemia. , 1999, Blood.
[36] J. Dick,et al. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell , 1997, Nature Medicine.
[37] F. E. Bertrand,et al. Targeting the leukemic stem cell: the Holy Grail of leukemia therapy , 2009, Leukemia.
[38] T. Naoe,et al. Homing, proliferation and survival sites of human leukemia cells in vivo in immunodeficient mice , 2007, Leukemia.