Tissue Engineering in Plastic Surgery: An Up-to-Date Review of the Current Literature

Tissue engineering is an interdisciplinary field that applies the principles of engineering and life sciences toward the development of biological substitutes that restore, maintain, or improve tissue function. This field has enjoyed tremendous growth in the past 10 years fuelled by its potential role in regenerating new tissues and naturally healing injured or diseased organs. Stem cells due to their pluripotentiality and unlimited capacity for self-renewal, may allow significant advances for distinct reconstructive and cosmetic procedures. This review aims at outlining the principles of tissue engineering, focusing on the use of adult-derived stem cells as applied to the research and practice of plastic surgery. Review categories have been divided into tissue engineering of the skin and connective tissue, bone marrow, cartilage, adipose tissue, and breast tissue. An analytical review of the current literature on stem cell technology on the above mentioned areas is presented. There have been reports of side effects and unsuccessful treatments. The key to the progress of tissue engineering is an understanding between basic scientists, biochemical engineers, clinicians, and industry. Although there has been an ongoing research pointing to the enormous potential of using stem cells in cosmetic and reconstructive surgery, at this stage, stem cell therapy is still a hope that has not been fully studied and approved. More long-term studies are needed and many questions remain to be answered.

[1]  F. Guilak,et al.  Effects of Transforming Growth Factor β1 and Dexamethasone on the Growth and Chondrogenic Differentiation of Adipose-Derived Stromal Cells , 2003 .

[2]  F. Guilak,et al.  Effects of transforming growth factor beta1 and dexamethasone on the growth and chondrogenic differentiation of adipose-derived stromal cells. , 2003, Tissue engineering.

[3]  C. Patrick,et al.  Long-term implantation of preadipocyte-seeded PLGA scaffolds. , 2002, Tissue engineering.

[4]  Catherine M. Verfaillie,et al.  Pluripotency of mesenchymal stem cells derived from adult marrow , 2007, Nature.

[5]  Y. Tabata,et al.  Time course of de novo adipogenesis in matrigel by gelatin microspheres incorporating basic fibroblast growth factor. , 2002, Tissue engineering.

[6]  D. Supp,et al.  Engineered skin substitutes: practices and potentials. , 2005, Clinics in dermatology.

[7]  L. Currie,et al.  The use of fibrin glue in skin grafts and tissue-engineered skin replacements: a review. , 2001, Plastic and reconstructive surgery.

[8]  Goberdhan P Dimri,et al.  Mammary epithelial cell transformation: insights from cell culture and mouse models , 2005, Breast Cancer Research.

[9]  C. Verfaillie,et al.  Origin of endothelial progenitors in human postnatal bone marrow. , 2002, The Journal of clinical investigation.

[10]  J. Visvader,et al.  Mammary stem cells and mammopoiesis. , 2006, Cancer research.

[11]  K. Ting,et al.  Scarless Fetal Wounds Are Associated with an Increased Matrix Metalloproteinase–to–Tissue-Derived Inhibitor of Metalloproteinase Ratio , 2003, Plastic and reconstructive surgery.

[12]  L. Hong,et al.  Adipose Tissue Engineering by Human Adipose-Derived Stromal Cells , 2006, Cells Tissues Organs.

[13]  M. Fussenegger,et al.  Stabilized Autologous Fibrin-Chondrocyte Constructs for Cartilage Repair in Vivo , 2003, Annals of plastic surgery.

[14]  G Cossu,et al.  Muscle regeneration by bone marrow-derived myogenic progenitors. , 1998, Science.

[15]  D. Hutmacher,et al.  In vivo mesenchymal cell recruitment by a scaffold loaded with transforming growth factor beta1 and the potential for in situ chondrogenesis. , 2002, Tissue engineering.

[16]  H. Hauner,et al.  Tissue engineering of white adipose tissue using hyaluronic acid-based scaffolds. I: in vitro differentiation of human adipocyte precursor cells on scaffolds. , 2003, Biomaterials.

[17]  B. Lim,et al.  Identification of Common Pathways Mediating Differentiation of Bone Marrow‐ and Adipose Tissue‐Derived Human Mesenchymal Stem Cells into Three Mesenchymal Lineages , 2007, Stem cells.

[18]  J. Mao,et al.  Adipose Tissue Engineering from Human Adult Stem Cells: Clinical Implications in Plastic and Reconstructive Surgery , 2007, Plastic and reconstructive surgery.

[19]  J. Gimble,et al.  Surface protein characterization of human adipose tissue‐derived stromal cells , 2001, Journal of cellular physiology.

[20]  F. Guilak,et al.  Clonal analysis of the differentiation potential of human adipose‐derived adult stem cells , 2006, Journal of cellular physiology.

[21]  W. Boecker,et al.  Evidence of progenitor cells of glandular and myoepithelial cell lineages in the human adult female breast epithelium: a new progenitor (adult stem) cell concept , 2003, Cell proliferation.

[22]  D. Orgill,et al.  Simultaneous in vivo regeneration of neodermis, epidermis, and basement membrane. , 2005, Advances in biochemical engineering/biotechnology.

[23]  K. Chua,et al.  Pediatric auricular chondrocytes gene expression analysis in monolayer culture and engineered elastic cartilage. , 2007, International journal of pediatric otorhinolaryngology.

[24]  G. Sukhikh,et al.  Mesenchymal Stem Cells , 2002, Bulletin of Experimental Biology and Medicine.

[25]  T. Matsuda,et al.  Novel strategy for soft tissue augmentation based on transplantation of fragmented omentum and preadipocytes. , 2004, Tissue engineering.

[26]  F. Guilak,et al.  Adipose-derived adult stem cells: isolation, characterization, and differentiation potential. , 2003, Cytotherapy.

[27]  A. Reddi,et al.  Stimulation of Proteoglycan Synthesis in Explants of Porcine Articular Cartilage by Recombinant Osteogenic Protein-1 (Bone Morphogenetic Protein-7)* , 1997, The Journal of bone and joint surgery. American volume.

[28]  S. Harper,et al.  VEGF and Angiopoietin‐1 Stimulate Different Angiogenic Phenotypes That Combine to Enhance Functional Neovascularization in Adult Tissue , 2006, Microcirculation.

[29]  P. Yaswen,et al.  TGFβ induction of extracellular matrix associated proteins in normal and transformed human mammary epithelial cells in culture is independent of growth effects , 1993 .

[30]  R. Bucala,et al.  Peripheral Blood Fibrocytes: Differentiation Pathway and Migration to Wound Sites1 , 2001, The Journal of Immunology.

[31]  Fulin Chen,et al.  Autologous injectable tissue-engineered cartilage by using platelet-rich plasma: experimental study in a rabbit model. , 2007, Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons.

[32]  Min Zhu,et al.  Comparison of Multi-Lineage Cells from Human Adipose Tissue and Bone Marrow , 2003, Cells Tissues Organs.

[33]  Haiyan I. Li,et al.  Purification and unique properties of mammary epithelial stem cells , 2006, Nature.

[34]  C. Patrick,et al.  Breast tissue engineering. , 2004, Annual review of biomedical engineering.

[35]  F. Stockdale,et al.  Cell-cell interactions promote mammary epithelial cell differentiation , 1985, The Journal of cell biology.

[36]  J. Visvader,et al.  The Emerging Picture of the Mouse Mammary Stem Cell , 2007, Stem Cell Reviews.

[37]  J. K. Bubien,et al.  Differentiation of adult bone marrow stem cells into neuroprogenitor cells in vitro , 2002, Neuroreport.

[38]  D L Butler,et al.  Autologous mesenchymal stem cell-mediated repair of tendon. , 1999, Tissue engineering.

[39]  E. Nicodemou-Lena,et al.  De novo adipogenesis in mice at the site of injection of basement membrane and basic fibroblast growth factor. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[40]  F. Watt,et al.  The cell-surface marker MTS24 identifies a novel population of follicular keratinocytes with characteristics of progenitor cells , 2006, Development.

[41]  F. Barry,et al.  Mesenchymal stem cells: clinical applications and biological characterization. , 2004, The international journal of biochemistry & cell biology.

[42]  Marc Hedrick,et al.  Healing of critically sized femoral defects, using genetically modified mesenchymal stem cells from human adipose tissue. , 2005, Tissue engineering.

[43]  P. Grimaldi,et al.  Cellular and molecular aspects of adipose tissue development. , 1992, Annual review of nutrition.

[44]  Linzhao Cheng,et al.  Human mesenchymal stem cells promote human osteoclast differentiation from CD34+ bone marrow hematopoietic progenitors. , 1999, Endocrinology.

[45]  François Vaillant,et al.  Generation of a functional mammary gland from a single stem cell , 2006, Nature.

[46]  Yaping Liu,et al.  Capturing and profiling adult hair follicle stem cells , 2004, Nature Biotechnology.

[47]  Stephen S. Park,et al.  Injectable tissue-engineered cartilage using a fibrin sealant. , 2007, Archives of facial plastic surgery.

[48]  M. Kassem,et al.  Human mesenchymal stem cells: from basic biology to clinical applications , 2008, Gene Therapy.

[49]  N. Scolding,et al.  Adult stem cells—reprogramming neurological repair? , 2004, The Lancet.

[50]  Ying Zheng,et al.  Organogenesis from dissociated cells: generation of mature cycling hair follicles from skin-derived cells. , 2005, The Journal of investigative dermatology.

[51]  S. O'Kane,et al.  Scar-free healing: from embryonic mechanisms to adult therapeutic intervention. , 2004, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[52]  Changyou Gao,et al.  Gelatin/chitosan/hyaluronan ternary complex scaffold containing basic fibroblast growth factor for cartilage tissue engineering , 2007, Journal of materials science. Materials in medicine.

[53]  B. Atiyeh,et al.  Cultured epithelial autograft (CEA) in burn treatment: three decades later. , 2007, Burns : journal of the International Society for Burn Injuries.

[54]  A. Hachiya,et al.  An in vivo mouse model of human skin substitute containing spontaneously sorted melanocytes demonstrates physiological changes after UVB irradiation. , 2005, The Journal of investigative dermatology.

[55]  B. Zhong,et al.  Hair follicle reformation induced by dermal papilla cells from human scalp skin , 2006, Archives of Dermatological Research.

[56]  M. Sefton,et al.  Tissue engineering. , 1998, Journal of cutaneous medicine and surgery.

[57]  A. Thambyah,et al.  Cell-based therapy in the repair of osteochondral defects: a novel use for adipose tissue. , 2003, Tissue engineering.

[58]  Lucie Germain,et al.  Inosculation of Tissue‐Engineered Capillaries with the Host's Vasculature in a Reconstructed Skin Transplanted on Mice , 2005, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[59]  Min Zhu,et al.  Human adipose tissue is a source of multipotent stem cells. , 2002, Molecular biology of the cell.

[60]  Anna Gutowska,et al.  Thermogelling biodegradable copolymer aqueous solutions for injectable protein delivery and tissue engineering. , 2002, Biomacromolecules.

[61]  I. Sekiya,et al.  Adipogenic Differentiation of Human Adult Stem Cells From Bone Marrow Stroma (MSCs) , 2003, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[62]  W W Minuth,et al.  Tissue engineering and autologous transplant formation: practical approaches with resorbable biomaterials and new cell culture techniques. , 1996, Biomaterials.