SYNTHESIS , CHARACTERIZATION AND STUDY BIOLOGICAL ACTIVITY SOME NEW DERIVATIVES AMIDE AND PYRAZOLE –PYRAZOLINE OF STEROID ANALOGS .

ABSTRACT       The number of steroids and their derivatives possess divers pharmacological activities as drugs for the treatment of a large number of diseases so in this work was suggested prepared  two series amides and pyrazoles of steroid analogs ( methyl((5-pregnant-3β,17-diol-15-yl) thio) propanoate) .   Amides derivatives ( 6 - 9 ) prepared directionally after treated the steroid analogs with primary amine substituted in basic medium  .      Carbo hydrazide steroid derivative (10 ) was obtained by treated steroid analogs with hydrazine hydrate , this compound use as intermediate for synthesis Pyrazolin (13 )  as well as  Pyrazole (14) . All the newly synthesized compounds have been identified by IR, 1H NMR, 13CNMR, 2D-NMR     ( HMBC , HSQC )  and C.H.N Analysis