No Association of a Functional Polymorphism in the Serotonin Transporter Gene Promoter and Anxiety-Related Personality Traits

Serotonergic neurotransmission, which is involved in many psychiatric disorders, is mediated by the serotonin transporter protein. Gene coding for the serotonin transporter protein is designated SLC6A4, which has been differentially associated with anxiety-related behavioral traits and neuroticism in healthy subjects. To confirm the association between the serotonin transporter (5-HTT) gene-linked polymorphic region (5-HTTLPR) and anxiety-related personality traits, we examined 228 healthy unrelated participants (age 38.6 ± 12.8 years; 115 male, 113 female) of German origin, who were carefully examined with respect to psychiatric health. The self-ratable State-Trait Anxiety Inventory (STAI) and the NEO Five Factor Inventory (NEO-FFI) were performed. No significant association was observed between the 5-HTTLPR genotype and STAI 1 (state, χ2 = 0.82, p < 0.66, d.f. = 2), STAI 2 (trait, χ2 = 2.7, p < 0.25, d.f. = 2) and NEO-FFI scores of any of the 5 major axes, including neuroticism (χ2 = 3.35, p < 0.18, d.f. = 2) in all subjects. Given the small effect of this 5-HTT polymorphism on behaviour in previous studies, a lack of significant genotype differences in these tests could be due to considerable individual variability in these measures.

[1]  Francesco Fera,et al.  The Amygdala Response to Emotional Stimuli: A Comparison of Faces and Scenes , 2002, NeuroImage.

[2]  Daniel Senkowski,et al.  Allelic Variants of the Functional Promoter Polymorphism of the Human Serotonin Transporter Gene is Associated with Auditory Cortical Stimulus Processing , 2003, Neuropsychopharmacology.

[3]  Henry Kranzler,et al.  Serotonin transporter protein (SLC6A4) allele and haplotype frequencies and linkage disequilibria in African- and European-American and Japanese populations and in alcohol-dependent subjects , 1997, Human Genetics.

[4]  C. McDougle,et al.  Evidence for linkage disequilibrium between serotonin transporter protein gene (SLC6A4) and obsessive compulsive disorder , 1998, Molecular Psychiatry.

[5]  M Linnoila,et al.  Role of the serotonin transporter promoter polymorphism in anxiety-related traits. , 1998, Archives of general psychiatry.

[6]  K. Lesch,et al.  Association analysis of a regulatory variation of the serotonin transporter gene with severe alcohol dependence. , 1997, Alcoholism, clinical and experimental research.

[7]  K. Kotani,et al.  Anxiety traits associated with a polymorphism in the serotonin transporter gene regulatory region in the Japanese , 1999, Journal of Human Genetics.

[8]  J. Flory,et al.  Neuroticism is not associated with the serotonin transporter (5-HTTLPR) polymorphism , 1999, Molecular Psychiatry.

[9]  P Riederer,et al.  Allelic Variation of Human Serotonin Transporter Gene Expression , 1996, Journal of neurochemistry.

[10]  P. Hrdina,et al.  Gender differences in association between serotonin transporter gene polymorphism and personality traits. , 2000, Psychiatric genetics.

[11]  K. Ohara,et al.  Functional polymorphism in the serotonin transporter promoter at the SLC6A4 locus and mood disorders , 1998, Biological Psychiatry.

[12]  M. Prior,et al.  Association of a functional polymorphism of the serotonin transporter gene with anxiety-related temperament and behavior problems in children: a longitudinal study from infancy to the mid-teens , 2000, Molecular Psychiatry.

[13]  Pt Jr Costa.  Revised NEO Personality Inventory and NEO Five-Factor Inventory , 1992 .

[14]  D. Ball,et al.  The serotonin transporter gene and peer‐rated neuroticism , 1997, Neuroreport.

[15]  Marcia M. Miller,et al.  Genotyping chickens for the B-G subregion of the major histocompatibility complex using restriction fragment length polymorphisms , 2004, Immunogenetics.

[16]  R. Ebstein,et al.  No association between the serotonin transporter gene regulatory region polymorphism and the Tridimensional Personality Questionnaire (TPQ) temperament of harm avoidance , 1997, Molecular Psychiatry.

[17]  N J Cox,et al.  Evidence of linkage between the serotonin transporter and autistic disorder , 1997, Molecular Psychiatry.

[18]  K. Lesch,et al.  Association of Anxiety-Related Traits with a Polymorphism in the Serotonin Transporter Gene Regulatory Region , 1996, Science.

[19]  D. Murphy,et al.  Association between the serotonin transporter promoter polymorphism and personality traits in a primarily female population sample. , 2000, American journal of medical genetics.

[20]  J Melke,et al.  Serotonin transporter gene polymorphisms are associated with anxiety-related personality traits in women. , 2001, American journal of medical genetics.

[21]  D. Sheehan,et al.  The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. , 1998, The Journal of clinical psychiatry.

[22]  L. Siever,et al.  Serotonin transporter protein gene polymorphism and personality measures in African American and European American subjects. , 1998, The American journal of psychiatry.