The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

[1]  Anne J. Ridley,et al.  The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors , 1992, Cell.

[2]  S. Grinstein,et al.  Phorbol ester-induced actin assembly in neutrophils: role of protein kinase C , 1992, The Journal of cell biology.

[3]  K. Kaibuchi,et al.  Both stimulatory and inhibitory GDP/GTP exchange proteins, smg GDS and rho GDI, are active on multiple small GTP-binding proteins. , 1992, Biochemical and biophysical research communications.

[4]  G. Bokoch,et al.  Regulation of phagocyte oxygen radical production by the GTP-binding protein Rac 2. , 1991, Science.

[5]  M. Roudebush,et al.  Dominant inhibitory Ras mutants demonstrate the requirement for Ras activity in the action of tyrosine kinase oncogenes. , 1991, Oncogene.

[6]  J. L. Bos,et al.  Two dominant inhibitory mutants of p21ras interfere with insulin-induced gene expression , 1991, Molecular and cellular biology.

[7]  F. Morel,et al.  The superoxide-generating oxidase of phagocytic cells , 1991 .

[8]  D. Lauffenburger,et al.  Kinetic analysis of F-actin depolymerization in polymorphonuclear leukocyte lysates indicates that chemoattractant stimulation increases actin filament number without altering the filament length distribution , 1991, The Journal of cell biology.

[9]  A. Abo,et al.  Activation of the NADPH oxidase involves the small GTP-binding protein p21rac1 , 1991, Nature.

[10]  L. Feig,et al.  Dominant inhibitory mutations in the Mg(2+)-binding site of RasH prevent its activation by GTP , 1991, Molecular and cellular biology.

[11]  J B Gibbs,et al.  Dominant inhibitory Ras mutants selectively inhibit the activity of either cellular or oncogenic Ras , 1991, Molecular and cellular biology.

[12]  C. Hall,et al.  Bcr encodes a GTPase-activating protein for p21rac , 1991, Nature.

[13]  J. Moll,et al.  The murine rac1 gene: cDNA cloning, tissue distribution and regulated expression of rac1 mRNA by disassembly of actin microfilaments. , 1991, Oncogene.

[14]  Michael Cross,et al.  Growth factors in development, transformation, and tumorigenesis , 1991, Cell.

[15]  R. Feldman,et al.  Molecular cloning of the bombesin/gastrin-releasing peptide receptor from Swiss 3T3 cells. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[16]  Frank McCormick,et al.  The GTPase superfamily: conserved structure and molecular mechanism , 1991, Nature.

[17]  J Downward,et al.  The ras superfamily of small GTP-binding proteins. , 1990, Trends in biochemical sciences.

[18]  H. Keller Diacylglycerols and PMA are particularly effective stimulators of fluid pinocytosis in human neutrophils , 1990, Journal of cellular physiology.

[19]  G. Cooper,et al.  Effect of a dominant inhibitory Ha-ras mutation on mitogenic signal transduction in NIH 3T3 cells , 1990, Molecular and cellular biology.

[20]  A. Hall,et al.  Microinjection of recombinant p21rho induces rapid changes in cell morphology , 1990, The Journal of cell biology.

[21]  P. Warne,et al.  Stimulation of p21ras upon T-cell activation , 1990, Nature.

[22]  A. Hall,et al.  The cellular functions of small GTP-binding proteins. , 1990, Science.

[23]  J. Pringle,et al.  CDC42 and CDC43, two additional genes involved in budding and the establishment of cell polarity in the yeast Saccharomyces cerevisiae , 1990, The Journal of cell biology.

[24]  J. Pringle,et al.  Molecular characterization of CDC42, a Saccharomyces cerevisiae gene involved in the development of cell polarity , 1990, The Journal of cell biology.

[25]  R. Portmann,et al.  The protein kinase C inhibitor H-7 activates human neutrophils: effect on shape, actin polymerization, fluid pinocytosis and locomotion. , 1990, Journal of cell science.

[26]  R. Pignolo,et al.  A member of the ras gene superfamily is expressed specifically in T, B and myeloid hemopoietic cells. , 1990, Oncogene.

[27]  Kees Jalink,et al.  Lysophosphatidate-induced cell proliferation: Identification and dissection of signaling pathways mediated by G proteins , 1989, Cell.

[28]  G M Bokoch,et al.  rac, a novel ras-related family of proteins that are botulinum toxin substrates. , 1989, The Journal of biological chemistry.

[29]  S. Narumiya,et al.  Asparagine residue in the rho gene product is the modification site for botulinum ADP-ribosyltransferase. , 1989, The Journal of biological chemistry.

[30]  P. Boquet,et al.  The mammalian G protein rhoC is ADP‐ribosylated by Clostridium botulinum exoenzyme C3 and affects actin microfilaments in Vero cells. , 1989, The EMBO journal.

[31]  A. Hall,et al.  p21H‐ras‐induced morphological transformation and increases in c‐myc expression are independent of functional protein kinase C. , 1989, The EMBO journal.

[32]  G. Cooper,et al.  Inhibition of NIH 3T3 cell proliferation by a mutant ras protein with preferential affinity for GDP , 1988, Molecular and cellular biology.

[33]  D. Smith,et al.  Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase. , 1988, Gene.

[34]  D. Stacey,et al.  Cellular ras activity and phospholipid metabolism , 1988, Cell.

[35]  S. Zigmond,et al.  An actin-nucleating activity in polymorphonuclear leukocytes is modulated by chemotactic peptides , 1986, The Journal of cell biology.

[36]  R. Germain,et al.  Efficient cell surface expression of class II MHC molecules in the absence of associated invariant chain , 1986, The Journal of experimental medicine.

[37]  D. Bar-Sagi,et al.  Induction of membrane ruffling and fluid-phase pinocytosis in quiescent fibroblasts by ras proteins. , 1986, Science.

[38]  A. Hall,et al.  The effect of Mg2+ on the guanine nucleotide exchange rate of p21N-ras. , 1986, The Journal of biological chemistry.

[39]  G K Lewis,et al.  Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product , 1985, Molecular and cellular biology.

[40]  Mark R. Smith,et al.  Requirement for ras proto-oncogene function during serum-stimulated growth of NIH 3T3 cells , 1985, Nature.

[41]  E. Scolnick,et al.  Monoclonal antibodies to the p21 products of the transforming gene of Harvey murine sarcoma virus and of the cellular ras gene family , 1982, Journal of virology.

[42]  E. Rozengurt Signal transduction pathways in mitogenesis. , 1989, British medical bulletin.

[43]  Y. Fujio,et al.  Tumor promoter induces reorganization of actin filaments and calspectin (fodrin or nonerythroid spectrin) in 3T3 cells. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[44]  D. Bar-Sagi,et al.  Inhibition of cell surface ruffling and fluid‐phase pinocytosis by microinjection of anti‐ras antibodies into living cells , 1987, Journal of cellular physiology. Supplement.

[45]  G. Bokoch,et al.  Signal transduction and cytoskeletal activation in the neutrophil. , 1987, Physiological reviews.