Normal brain and brain tumor: multicomponent apparent diffusion coefficient line scan imaging.

Magnetic resonance line scan diffusion imaging of the brain, with diffusion weighting between 5 and 5,000 sec/mm(2), was performed in healthy subjects and patients with a 1.5-T machine. For each voxel, biexponential signal decay fits produced two apparent diffusion constants and respective signal amplitudes. Images based on these parameters show potential for use in the differentiation of gray and white matter, edema, and tumor.

[1]  R. Damadian.  Tumor Detection by Nuclear Magnetic Resonance , 1971, Science.

[2]  W. T. Dixon,et al.  Separation of diffusion and perfusion in intravoxel incoherent motion MR imaging: a modest proposal with tremendous potential. , 1988, Radiology.

[3]  J. Pekar,et al.  Echo-planar imaging of intravoxel incoherent motion. , 1990, Radiology.

[4]  C T Moonen,et al.  Complete separation of intracellular and extracellular information in NMR spectra of perfused cells by diffusion-weighted spectroscopy. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[5]  M. Neeman,et al.  Self-diffusion of water in multicellular spheroids measured by magnetic resonance microimaging. , 1991, Cancer research.

[6]  D. Bihan,et al.  4809701 Method to measure the molecular diffusion and/or perfusion parameters of live tissue , 1991 .

[7]  D. LeBihan,et al.  Molecular diffusion nuclear magnetic resonance imaging. , 1991 .

[8]  D. Le Bihan.  Molecular diffusion nuclear magnetic resonance imaging. , 1991, Magnetic resonance quarterly.

[9]  J. Tsuruda,et al.  Diffusion‐weighted MR imaging of extraaxial tumors , 1991, Magnetic resonance in medicine.

[10]  J V Hajnal,et al.  MR imaging of anisotropically restricted diffusion of water in the nervous system: technical, anatomic, and pathologic considerations. , 1991, Journal of computer assisted tomography.

[11]  Wei Li,et al.  Fast magnetic resonance diffusion‐weighted imaging of acute human stroke , 1992, Neurology.

[12]  J. Tsuruda,et al.  Cytotoxic brain edema: assessment with diffusion-weighted MR imaging. , 1992, Radiology.

[13]  Robert Turner,et al.  Diffusion and perfusion magnetic resonance imaging in brain tumors , 1993, Topics in magnetic resonance imaging : TMRI.

[14]  M Hoehn-Berlage,et al.  Quantitative diffusion MR imaging of cerebral tumor and edema. , 1994, Acta neurochirurgica. Supplementum.

[15]  M. Edwards-Brown.  Supratentorial brain tumors. , 1994, Neuroimaging clinics of North America.

[16]  R D Tien,et al.  MR imaging of high-grade cerebral gliomas: value of diffusion-weighted echoplanar pulse sequences. , 1994, AJR. American journal of roentgenology.

[17]  A. Matsumura,et al.  Clinical application of diffusion-weighted magnetic resonance imaging to intracranial disorders. , 1995, Neurologia medico-chirurgica.

[18]  J G Pipe,et al.  In vivo MR determination of water diffusion coefficients and diffusion anisotropy: correlation with structural alteration in gliomas of the cerebral hemispheres. , 1995, AJNR. American journal of neuroradiology.

[19]  T E Conturo,et al.  Diffusion MRI: Precision, accuracy and flow effects , 1995, NMR in biomedicine.

[20]  S. Maier,et al.  Line scan diffusion imaging , 1996, Magnetic resonance in medicine.

[21]  D. Norris,et al.  Biexponential diffusion attenuation in various states of brain tissue: Implications for diffusion‐weighted imaging , 1996, Magnetic resonance in medicine.

[22]  James R. Moore,et al.  Correction for distortion of echo‐planar images used to calculate the apparent diffusion coefficient , 1996, Magnetic resonance in medicine.

[23]  K. Krabbe,et al.  MR diffusion imaging of human intracranial tumours , 1997, Neuroradiology.

[24]  D Artemov,et al.  Intracellular volume and apparent diffusion constants of perfused cancer cell cultures, as measured by NMR , 1997, Magnetic resonance in medicine.

[25]  P. Batchelor,et al.  International Society for Magnetic Resonance in Medicine , 1997 .

[26]  S. Maier,et al.  Line scan diffusion imaging: characterization in healthy subjects and stroke patients. , 1998, AJR. American journal of roentgenology.

[27]  P. Basser,et al.  A simplified method to measure the diffusion tensor from seven MR images , 1998, Magnetic resonance in medicine.

[28]  R V Mulkern,et al.  MR line scan diffusion imaging of the brain in children. , 1999, AJNR. American journal of neuroradiology.

[29]  C. Westin,et al.  Multi‐component apparent diffusion coefficients in human brain † , 1999, NMR in biomedicine.

[30]  K. Zou,et al.  Multi‐component apparent diffusion coefficients in human brain: Relationship to spin‐lattice relaxation , 2000, Magnetic resonance in medicine.