Chiral Piperazine‐2,5‐dione Derivatives as Effective α‐Glucosidase Inhibitors. Part 4

The potential to inhibit α‐ and β‐glucosidases of a series of chiral piperazine‐2,5‐dione derivatives was investigated. Three of the seven compounds tested, viz., 1, 5b, and 5c, showed to be non competitive inhibitors of α‐glucosidase, whereas they exhibited very low inhibitory activity towards β‐glucosidase. The most active compound, 5c (KI of α‐glucosidase=5 μm), had a 100‐fold α‐glucosidase/β‐glucosidase inhibitor selectivity.

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