Four new coumarin glucosides from the roots of Heracleum rapula

Four new coumarin glucosides, 7-O-[β-D-glucopyranosyl-(1R 2) -β-D-glucopyranosyl]demethylsuberosin (1), 8-O-[β-D-apiofuranosyl-(1R 6) -β-D-glucopyranosyl]-8-hydroxybergapten (2), 8-O-[β-D-apiofuranosyl-(1R 6) -β-D-glucopyranosyl]xanthotoxol (3), and 5-O-[β-D-glucopyranosyl-(1R 6) -β-D-glucopyranosyl]-8-hydroxybergaptol (4), were isolated from the roots of Heracleum rapula. The structures of these compounds were determined on the basis of their 1D NMR, 2D NMR and HRMS spectral data. Their inhibitory effects on rabbit platelet aggregation respectively induced by PAF, AA and APD were tested. Weak to moderate inhibitory activities for each compound were observed.