Bone morphogenetic protein signaling is impaired in an HFE knockout mouse model of hemochromatosis.
暂无分享,去创建一个
B. Andriopoulos | Herbert Y. Lin | Jodie L Babitt | A. Pietrangelo | P. Ventura | E. Corradini | C. Garuti | G. Montosi
[1] H. Tsukamoto,et al. Interaction of the hereditary hemochromatosis protein HFE with transferrin receptor 2 is required for transferrin-induced hepcidin expression. , 2009, Cell metabolism.
[2] M. Roth,et al. Lack of the bone morphogenetic protein BMP6 induces massive iron overload , 2009, Nature Genetics.
[3] Yin Xia,et al. BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism , 2009, Nature Genetics.
[4] Jean Mosser,et al. Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver. , 2008, Blood.
[5] R. Chung,et al. Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin. , 2008, Blood.
[6] Matthias W. Hentze,et al. A bone morphogenetic protein (BMP)-responsive element in the hepcidin promoter controls HFE2-mediated hepatic hepcidin expression and its response to IL-6 in cultured cells , 2008, Journal of Molecular Medicine.
[7] N. Andrews,et al. The transferrin receptor modulates Hfe-dependent regulation of hepcidin expression. , 2008, Cell metabolism.
[8] C. Enns,et al. HFE Modulates Transferrin Receptor 2 Levels in Hepatoma Cells via Interactions That Differ from Transferrin Receptor 1-HFE Interactions* , 2007, Journal of Biological Chemistry.
[9] D. Girelli,et al. Blunted hepcidin response to oral iron challenge in HFE-related hemochromatosis. , 2007, Blood.
[10] M. Hentze,et al. Hfe acts in hepatocytes to prevent hemochromatosis. , 2007, Cell metabolism.
[11] E. Beutler,et al. Different regulatory elements are required for response of hepcidin to interleukin‐6 and bone morphogenetic proteins 4 and 9 , 2007, British journal of haematology.
[12] Yin Xia,et al. Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance. , 2007, The Journal of clinical investigation.
[13] N. Andrews,et al. Hereditary Hemochromatosis Protein, HFE, Interaction with Transferrin Receptor 2 Suggests a Molecular Mechanism for Mammalian Iron Sensing* , 2006, Journal of Biological Chemistry.
[14] E. Beutler,et al. Bone morphogenetic proteins 2, 4, and 9 stimulate murine hepcidin 1 expression independently of Hfe, transferrin receptor 2 (Tfr2), and IL-6 , 2006, Proceedings of the National Academy of Sciences.
[15] Raymond T Chung,et al. Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression , 2006, Nature Genetics.
[16] C. Deng,et al. A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression. , 2005, Cell metabolism.
[17] W. Stremmel,et al. Iron Stores Modulate Hepatic Hepcidin Expression by an HFE-Independent Pathway , 2005, Digestion.
[18] S. Arber,et al. Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload. , 2005, The Journal of clinical investigation.
[19] G. Pinkus,et al. A mouse model of juvenile hemochromatosis. , 2005, The Journal of clinical investigation.
[20] F. Ferrara,et al. Kupffer cells and macrophages are not required for hepatic hepcidin activation during iron overload , 2005, Hepatology.
[21] Jerry Kaplan,et al. Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization , 2004, Science.
[22] A. M. Giannetti,et al. HFE and Transferrin Directly Compete for Transferrin Receptor in Solution and at the Cell Surface* , 2004, Journal of Biological Chemistry.
[23] A. Pietrangelo. Hereditary hemochromatosis--a new look at an old disease. , 2004, The New England journal of medicine.
[24] J. Massagué,et al. Mechanisms of TGF-β Signaling from Cell Membrane to the Nucleus , 2003, Cell.
[25] M. Hentze,et al. Regulatory defects in liver and intestine implicate abnormal hepcidin and Cybrd1 expression in mouse hemochromatosis , 2003, Nature Genetics.
[26] N. Andrews,et al. Constitutive hepcidin expression prevents iron overload in a mouse model of hemochromatosis , 2003, Nature Genetics.
[27] D. Purdie,et al. Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis , 2003, The Lancet.
[28] W. Sly,et al. Decreased liver hepcidin expression in the Hfe knockout mouse. , 2002, Blood cells, molecules & diseases.
[29] K. Miyazono,et al. Id: A Target of BMP Signaling , 2002, Science's STKE.
[30] P. ten Dijke,et al. Identification and Functional Characterization of Distinct Critically Important Bone Morphogenetic Protein-specific Response Elements in the Id1 Promoter* , 2002, The Journal of Biological Chemistry.
[31] L. Weiner,et al. Mutational analysis of the transferrin receptor reveals overlapping HFE and transferrin binding sites. , 2001, Journal of molecular biology.
[32] Christina H. Park,et al. Hepcidin, a Urinary Antimicrobial Peptide Synthesized in the Liver* , 2001, The Journal of Biological Chemistry.
[33] Bruno Turlin,et al. A New Mouse Liver-specific Gene, Encoding a Protein Homologous to Human Antimicrobial Peptide Hepcidin, Is Overexpressed during Iron Overload* , 2001, The Journal of Biological Chemistry.
[34] Peter Schulz-Knappe,et al. LEAP‐1, a novel highly disulfide‐bonded human peptide, exhibits antimicrobial activity , 2000, FEBS letters.
[35] P. Bjorkman,et al. Crystal structure of the hereditary haemochromatosis protein HFE complexed with transferrin receptor , 2000, Nature.
[36] A. West,et al. The hemochromatosis protein HFE competes with transferrin for binding to the transferrin receptor. , 1999, Journal of molecular biology.
[37] S. Bahram,et al. Experimental hemochromatosis due to MHC class I HFE deficiency: immune status and iron metabolism. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[38] Dena E. Cohen,et al. The C282Y mutation causing hereditary hemochromatosis does not produce a null allele. , 1999, Blood.
[39] W. Sly,et al. Association of HFE protein with transferrin receptor in crypt enterocytes of human duodenum. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[40] W. Sly,et al. HFE gene knockout produces mouse model of hereditary hemochromatosis. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[41] D. M. Penny,et al. The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[42] W. Sly,et al. Association of the transferrin receptor in human placenta with HFE, the protein defective in hereditary hemochromatosis. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[43] W. Sly,et al. Hereditary hemochromatosis: effects of C282Y and H63D mutations on association with beta2-microglobulin, intracellular processing, and cell surface expression of the HFE protein in COS-7 cells. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[44] R. Wolff,et al. The Hemochromatosis Founder Mutation in HLA-H Disrupts β2-Microglobulin Interaction and Cell Surface Expression* , 1997, The Journal of Biological Chemistry.
[45] Jennifer J. Pointon,et al. Global prevalence of putative haemochromatosis mutations. , 1997, Journal of medical genetics.
[46] M. C. Ellis,et al. A novel MHC class I–like gene is mutated in patients with hereditary haemochromatosis , 1996, Nature Genetics.
[47] I. Cavill,et al. Synopsis of Pathology , 1981 .
[48] Charles C Hong,et al. Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism. , 2008, Nature chemical biology.
[49] Marie-Pierre Dubé,et al. Mutations in HFE2 cause iron overload in chromosome 1q–linked juvenile hemochromatosis , 2004, Nature Genetics.
[50] J. Torrance. Tissue iron stores , 1980 .