Microwave-induced Stereoselectivity in Synthesis of trans-4-Aryl-3-methyl-6-oxo-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-b]pyridine-5-carbonitriles

A facile synthesis of trans isomers of 4-aryl-3-methyl-6-oxo-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-b]pyridine-5-carbonitriles via three-component condensation reaction of an aldehyde, 3-amino-5-methylpyrazole and ethyl cyanoacetate in acetonitrile has been developed under microwave irradiation. This one-pot reaction proceeds without any catalyst in short times and gives the product in high selectivities and high yields.

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