Chemoproteomics as a basis for post-genomic drug discovery.
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[1] L. Goodman,et al. The Pharmacological Basis of Therapeutics , 1941 .
[2] A. Goldstein,et al. Stereospecific and nonspecific interactions of the morphine congener levorphanol in subcellular fractions of mouse brain. , 1971, Proceedings of the National Academy of Sciences of the United States of America.
[3] J. Topliss,et al. Chance factors in studies of quantitative structure-activity relationships. , 1979, Journal of medicinal chemistry.
[4] P. Willett,et al. A Comparison of Some Measures for the Determination of Inter‐Molecular Structural Similarity Measures of Inter‐Molecular Structural Similarity , 1986 .
[5] W. Stigelman,et al. Goodman and Gilman's the Pharmacological Basis of Therapeutics , 1986 .
[6] Marvin Johnson,et al. Concepts and applications of molecular similarity , 1990 .
[7] Yvonne C. Martin,et al. A fast new approach to pharmacophore mapping and its application to dopaminergic and benzodiazepine agonists , 1993, J. Comput. Aided Mol. Des..
[8] P. Skolnick,et al. Synthesis of benzo-fused benzodiazepines employed as probes of the agonist pharmacophore of benzodiazepine receptors. , 1994, Journal of medicinal chemistry.
[9] Hans-Joachim Böhm,et al. The development of a simple empirical scoring function to estimate the binding constant for a protein-ligand complex of known three-dimensional structure , 1994, J. Comput. Aided Mol. Des..
[10] David M. Rocke,et al. Predicting ligand binding to proteins by affinity fingerprinting. , 1995, Chemistry & biology.
[11] D. E. Patterson,et al. Designing Chemical Libraries for Lead Discovery , 1996 .
[12] T. Reisine. Opioid analgesics and antagonists , 1996 .
[13] W. Guida,et al. The art and practice of structure‐based drug design: A molecular modeling perspective , 1996, Medicinal research reviews.
[14] Yvonne C. Martin,et al. Use of Structure-Activity Data To Compare Structure-Based Clustering Methods and Descriptors for Use in Compound Selection , 1996, J. Chem. Inf. Comput. Sci..
[15] Gennady M Verkhivker,et al. Unraveling principles of lead discovery: from unfrustrated energy landscapes to novel molecular anchors. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[16] J. Onuchic,et al. Theory of protein folding: the energy landscape perspective. , 1997, Annual review of physical chemistry.
[17] J M Blaney,et al. Computational approaches for combinatorial library design and molecular diversity analysis. , 1997, Current opinion in chemical biology.
[18] Yvonne C. Martin,et al. The Information Content of 2D and 3D Structural Descriptors Relevant to Ligand-Receptor Binding , 1997, J. Chem. Inf. Comput. Sci..
[19] F. Lombardo,et al. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings , 1997 .
[20] H. Matter,et al. Selecting optimally diverse compounds from structure databases: a validation study of two-dimensional and three-dimensional molecular descriptors. , 1997, Journal of medicinal chemistry.
[21] Ajay,et al. Can we learn to distinguish between "drug-like" and "nondrug-like" molecules? , 1998, Journal of medicinal chemistry.
[22] John H. Van Drie,et al. Approaches to virtual library design , 1998 .
[23] H O Villar,et al. Protein affinity map of chemical space. , 1998, Journal of chromatography. B, Biomedical sciences and applications.
[24] M. Justice,et al. Functional genomics in the post-genome era. , 1998, Mutation research.
[25] H. Kubinyi,et al. A scoring scheme for discriminating between drugs and nondrugs. , 1998, Journal of medicinal chemistry.
[26] Mark A. Murcko,et al. Virtual screening : an overview , 1998 .
[27] Steven L. Dixon,et al. Bioactive Diversity and Screening Library Selection via Affinity Fingerprinting , 1998, J. Chem. Inf. Comput. Sci..
[28] Steven L. Dixon,et al. Investigation of classification methods for the prediction of activity in diverse chemical libraries , 1999, J. Comput. Aided Mol. Des..
[29] Robert S. Pearlman,et al. Metric Validation and the Receptor-Relevant Subspace Concept , 1999, J. Chem. Inf. Comput. Sci..
[30] R. Cramer,et al. Prospective identification of biologically active structures by topomer shape similarity searching. , 1999, Journal of medicinal chemistry.
[31] Yueh-Ching Chou,et al. Binding of dimemorfan to sigma-1 receptor and its anticonvulsant and locomotor effects in mice, compared with dextromethorphan and dextrorphan , 1999, Brain Research.
[32] David C. Spellmeyer,et al. Chapter 28. Recent Developments in Molecular Diversity: Computational Approaches to Combinatorial Chemistry , 1999 .
[33] Lenz,et al. Chemical ligands, genomics and drug discovery. , 2000, Drug discovery today.
[34] R. Cramer,et al. Toward general methods of targeted library design: topomer shape similarity searching with diverse structures as queries. , 2000, Journal of medicinal chemistry.
[35] Suto,et al. Designing chiral libraries for drug discovery. , 2000, Drug discovery today.
[36] P Willett,et al. Chemoinformatics - similarity and diversity in chemical libraries. , 2000, Current opinion in biotechnology.
[37] Drews. Drug discovery today - and tomorrow. , 2000, Drug discovery today.
[38] P. Beroza,et al. A rapid computational method for lead evolution: description and application to alpha(1)-adrenergic antagonists. , 2000, Journal of medicinal chemistry.
[39] Jürgen Bajorath,et al. Selected Concepts and Investigations in Compound Classification, Molecular Descriptor Analysis, and Virtual Screening , 2001, J. Chem. Inf. Comput. Sci..
[40] D. Agrafiotis,et al. Combinatorial informatics in the post-genomics era , 2002, Nature Reviews Drug Discovery.
[41] R. Finnell,et al. Molecular basis of environmentally induced birth defects. , 2003, Annual review of pharmacology and toxicology.
[42] John E Eksterowicz,et al. Evaluation of a novel shape-based computational filter for lead evolution: application to thrombin inhibitors. , 2002, Journal of medicinal chemistry.
[43] L. Cassis,et al. Errors introduced by a tritium label in position 8 of catecholamines , 2004, Naunyn-Schmiedeberg's Archives of Pharmacology.