Synthesis of cell-permeable stapled peptide dual inhibitors of the p53-Mdm2/Mdmx interactions via photoinduced cycloaddition.
暂无分享,去创建一个
Michael M. Madden | Qing Lin | Jiandong Chen | Qing Lin | Zhenyu Li | Avinash Muppidi | Xiaolong Li | Zhenyu Li | Jiandong Chen | Michael M Madden | Avinash Muppidi | Xiaolong Li
[1] P. Furet,et al. Discovery of potent antagonists of the interaction between human double minute 2 and tumor suppressor p53. , 2000, Journal of medicinal chemistry.
[2] A. Levine,et al. The p53-mdm-2 autoregulatory feedback loop. , 1993, Genes & development.
[3] A. Levine. p53, the Cellular Gatekeeper for Growth and Division , 1997, Cell.
[4] G. Verdine,et al. An All-Hydrocarbon Cross-Linking System for Enhancing the Helicity and Metabolic Stability of Peptides , 2000 .
[5] Baoli Hu,et al. Efficient p53 activation and apoptosis by simultaneous disruption of binding to MDM2 and MDMX. , 2007, Cancer research.
[6] Raymond E. Moellering,et al. Direct inhibition of the NOTCH transcription factor complex , 2009, Nature.
[7] D. George,et al. Stabilization of the MDM2 Oncoprotein by Interaction with the Structurally Related MDMX Protein* , 1999, The Journal of Biological Chemistry.
[8] F A Quiocho,et al. Target enzyme recognition by calmodulin: 2.4 A structure of a calmodulin-peptide complex. , 1992, Science.
[9] N. Tjandra,et al. BAX Activation is Initiated at a Novel Interaction Site , 2008, Nature.
[10] F. Bernal,et al. Synthesis and biophysical characterization of stabilized alpha-helices of BCL-2 domains. , 2008, Methods in enzymology.
[11] Clay Bracken,et al. SYNTHESIS AND NUCLEAR MAGNETIC RESONANCE STRUCTURE DETERMINATION OF AN ALPHA -HELICAL, BICYCLIC, LACTAM-BRIDGED HEXAPEPTIDE , 1994 .
[12] Michael M. Madden,et al. Facile synthesis of stapled, structurally reinforced peptide helices via a photoinduced intramolecular 1,3-dipolar cycloaddition reaction. , 2009, Chemical communications.
[13] D. Fairlie,et al. Downsizing human, bacterial, and viral proteins to short water-stable alpha helices that maintain biological potency , 2010, Proceedings of the National Academy of Sciences.
[14] Arjel D. Bautista,et al. Bridged beta(3)-peptide inhibitors of p53-hDM2 complexation: correlation between affinity and cell permeability. , 2010, Journal of the American Chemical Society.
[15] G. Dubin,et al. High affinity interaction of the p53 peptide-analogue with human Mdm2 and Mdmx , 2009, Cell cycle.
[16] A. Schepartz,et al. Minimally cationic cell-permeable miniature proteins via alpha-helical arginine display. , 2008, Journal of the American Chemical Society.
[17] Ernst Schönbrunn,et al. Structure-based Design of High Affinity Peptides Inhibiting the Interaction of p53 with MDM2 and MDMX* , 2009, The Journal of Biological Chemistry.
[18] Helen E Blackwell,et al. Highly Efficient Synthesis of Covalently Cross-Linked Peptide Helices by Ring-Closing Metathesis. , 1998, Angewandte Chemie.
[19] M. Geiser,et al. Crystal Structures of Human MdmX (HdmX) in Complex with p53 Peptide Analogues Reveal Surprising Conformational Changes* , 2009, Journal of Biological Chemistry.
[20] K. Shirouzu,et al. MDM2 interacts with MDMX through their RING finger domains , 1999, FEBS letters.
[21] W. Kabsch,et al. Dictionary of protein secondary structure: Pattern recognition of hydrogen‐bonded and geometrical features , 1983, Biopolymers.
[22] Samuel K Sia,et al. Short constrained peptides that inhibit HIV-1 entry , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[23] R. Meadows,et al. Structure of Bcl-xL-Bak Peptide Complex: Recognition Between Regulators of Apoptosis , 1997, Science.
[24] Robert S. McDowell,et al. A General Method for Constraining Short Peptides to an α-Helical Conformation , 1997 .
[25] S. Korsmeyer,et al. Activation of Apoptosis in Vivo by a Hydrocarbon-Stapled BH3 Helix , 2004, Science.
[26] A. Jochemsen,et al. MDMX: a novel p53‐binding protein with some functional properties of MDM2. , 1996, The EMBO journal.
[27] A. Ciechanover,et al. HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53 , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[28] S. Korsmeyer,et al. Reactivation of the p53 Tumor Suppressor Pathway by a Stapled p53 Peptide , 2007 .
[29] G. Wahl,et al. Regulating the p53 pathway: in vitro hypotheses, in vivo veritas , 2006, Nature Reviews Cancer.
[30] A. Levine,et al. Structure of the MDM2 Oncoprotein Bound to the p53 Tumor Suppressor Transactivation Domain , 1996, Science.
[31] Peter G. Schultz,et al. General approach to the synthesis of short .alpha.-helical peptides , 1991 .