goldfish (Carassius auratus)

Where does the species originate from? Nope, not the pet store. Goldfish are native to eastern and central Asia, and were originally bred from Prussian carp (Carassius auratus gibelio) more than a thousand years ago. Centuries of selective breeding has created all of the wacky color and body shapes that can be found in fish bowls around the globe. How are they introduced and spread? Goldfish have been farmed for live bait, intentionally stocked as forage fish, and sold worldwide for display in outdoor ponds, water gardens, and aquariums. Goldfish are often purchased as pets then released into the wild or flushed down a toilet when owners can no longer care for them. Goldfish are very greedy, opportunistic eaters. In the wild, goldfish consume everything from plants to aquatic insects, small snails and crustaceans. The rooting and foraging behavior of goldfish can increase water turbidity and reduce the abundance of aquatic vegetation. Goldfish may displace or outcompete native species for common food resources, introduce disease to native fish populations (goldfish ulcer disease), and can successfully hybridize with common carp – another problematic fish species. A group of goldfish is known as a " troubling ". Goldfish can tan in the sun just like humans. Goldfish have a memory-span of at least three months and can differentiate shapes, colors and sounds. Those beautiful bright colors that goldfish are so famous for make them very conspicuous and more susceptible to predation in the wild – not a very fond farewell for your fishy friend!

[1]  T. Plant,et al.  Repetitive activation of hypothalamic G protein-coupled receptor 54 with intravenous pulses of kisspeptin in the juvenile monkey (Macaca mulatta) elicits a sustained train of gonadotropin-releasing hormone discharges. , 2006, Endocrinology.

[2]  J. Thompson,et al.  CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. , 1994, Nucleic acids research.

[3]  A. Martínez-Fuentes,et al.  Direct Pituitary Effects of Kisspeptin: Activation of Gonadotrophs and Somatotrophs and Stimulation of Luteinising Hormone and Growth Hormone Secretion , 2007, Journal of neuroendocrinology.

[4]  R. Steiner,et al.  Kisspeptin Activation of Gonadotropin Releasing Hormone Neurons and Regulation of KiSS-1 mRNA in the Male Rat , 2005, Neuroendocrinology.

[5]  F. Monsma,et al.  The KiSS-1 receptor GPR54 is essential for the development of the murine reproductive system. , 2003, Biochemical and biophysical research communications.

[6]  S. Bloom,et al.  Central and Peripheral Administration of Kisspeptin‐10 Stimulates the Hypothalamic‐Pituitary‐Gonadal Axis , 2004, Journal of neuroendocrinology.

[7]  M. Tena-Sempere,et al.  Evidence for two distinct KiSS genes in non-placental vertebrates that encode kisspeptins with different gonadotropin-releasing activities in fish and mammals , 2009, Molecular and Cellular Endocrinology.

[8]  E. Génin,et al.  Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54 , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[9]  R. Steiner,et al.  Emerging ideas about kisspeptin– GPR54 signaling in the neuroendocrine regulation of reproduction , 2007, Trends in Neurosciences.

[10]  H. Vaudry,et al.  Molecular evolution of neuropeptide receptors with regard to maintaining high affinity to their authentic ligands. , 2007, General and comparative endocrinology.

[11]  O. Nishimura,et al.  Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor , 2001, Nature.

[12]  D. Ma,et al.  Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[13]  S. Brunak,et al.  Improved prediction of signal peptides: SignalP 3.0. , 2004, Journal of molecular biology.

[14]  S. Ben-Dor,et al.  Molecular Identification and Functional Characterization of the Kisspeptin/Kisspeptin Receptor System in Lower Vertebrates1 , 2008, Biology of reproduction.

[15]  C. Martyniuk,et al.  The goldfish (Carassius auratus) as a model for neuroendocrine signaling , 2008, Molecular and Cellular Endocrinology.

[16]  H. Matsumoto,et al.  Peripheral administration of metastin induces marked gonadotropin release and ovulation in the rat. , 2004, Biochemical and biophysical research communications.

[17]  Sudhir Kumar,et al.  MEGA3: Integrated software for Molecular Evolutionary Genetics Analysis and sequence alignment , 2004, Briefings Bioinform..

[18]  J. T. Smith,et al.  Kisspeptin is present in ovine hypophysial portal blood but does not increase during the preovulatory luteinizing hormone surge: evidence that gonadotropes are not direct targets of kisspeptin in vivo. , 2008, Endocrinology.

[19]  J. H. Lee,et al.  Suppression of metastasis in human breast carcinoma MDA-MB-435 cells after transfection with the metastasis suppressor gene, KiSS-1. , 1997, Cancer research.

[20]  J. Sánchez-Criado,et al.  Developmental and hormonally regulated messenger ribonucleic acid expression of KiSS-1 and its putative receptor, GPR54, in rat hypothalamus and potent luteinizing hormone-releasing activity of KiSS-1 peptide. , 2004, Endocrinology.

[21]  W. Colledge,et al.  Hypogonadotropic hypogonadism in mice lacking a functional Kiss1 gene , 2007, Proceedings of the National Academy of Sciences.

[22]  P. Emson,et al.  AXOR12, a Novel Human G Protein-coupled Receptor, Activated by the Peptide KiSS-1* , 2001, The Journal of Biological Chemistry.

[23]  S. Ogawa,et al.  Laser-captured single digoxigenin-labeled neurons of gonadotropin-releasing hormone types reveal a novel G protein-coupled receptor (Gpr54) during maturation in cichlid fish. , 2004, Endocrinology.

[24]  S. O’Rahilly,et al.  The GPR54 Gene as a Regulator of Puberty , 2003 .

[25]  S. Schiffmann,et al.  The Metastasis Suppressor Gene KiSS-1 Encodes Kisspeptins, the Natural Ligands of the Orphan G Protein-coupled Receptor GPR54* , 2001, The Journal of Biological Chemistry.

[26]  R. Peter,et al.  Gonadotropin release from the pars distalis of goldfish, Carassius auratus, transplanted beside the brain or into the brain ventricles: additional evidence for gonadotropin-release-inhibitory factor. , 1984, General and comparative endocrinology.

[27]  J. T. Smith,et al.  A Role for Kisspeptins in the Regulation of Gonadotropin Secretion in the Mouse Materials and Methods Animals and Chemicals , 2022 .

[28]  Mingyao Liu,et al.  Identification and characterization of mouse metastasis-suppressor KiSS1 and its G-protein-coupled receptor. , 2002, Cancer research.

[29]  R. Campbell,et al.  Co-evolution of ligand-receptor pairs , 1994, Nature.

[30]  S. Ojeda,et al.  Increased hypothalamic GPR54 signaling: a potential mechanism for initiation of puberty in primates. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[31]  S. Ogawa,et al.  Cloning and expression of kiss2 in the zebrafish and medaka. , 2009, Endocrinology.

[32]  W. Vale,et al.  Effects of [D-Arg6, Trp7, Leu8, Pro9NEt]-luteinizing hormone-releasing hormone (sGnRH-A) and [D-Ala6, Pro9NEt]-luteinizing hormone-releasing hormone (LHRH-A), in combination with pimozide or domperidone, on gonadotropin release and ovulation in the Chinese loach and common carp. , 1988, General and comparative endocrinology.

[33]  J M Trent,et al.  KiSS-1, a novel human malignant melanoma metastasis-suppressor gene. , 1996, Journal of the National Cancer Institute.

[34]  Bruce R. Southey,et al.  NeuroPred: a tool to predict cleavage sites in neuropeptide precursors and provide the masses of the resulting peptides , 2006, Nucleic Acids Res..

[35]  H. Vaudry,et al.  Molecular cloning of the bullfrog kisspeptin receptor GPR54 with high sensitivity to Xenopus kisspeptin , 2009, Peptides.

[36]  T. Schwartz,et al.  Molecular mechanism of 7TM receptor activation--a global toggle switch model. , 2006, Annual review of pharmacology and toxicology.

[37]  S. Suzuki,et al.  Direct kisspeptin-10 stimulation on luteinizing hormone secretion from bovine and porcine anterior pituitary cells. , 2008, Animal reproduction science.