Crohn's disease is characterized by chronic inflammation of the digestive tract which may be localized at any level. Nonetheless, esophageal disease is infrequent. Two cases of esophageal involvement in this disease in 2 young women with a history of previous involvement at an intestinal level are presented. Esophageal involvement by Crohn's disease should be suspected in any patient previously diagnosed with this disease who presents symptoms suggestive of esophagitis, using endoscopy with multiples biopsies of the affected areas and other of normal endoscopic appearance for diagnosis.