Adiponectin, Leptin, and Fatty Acids in the Maintenance of Metabolic Homeostasis through Adipose Tissue Crosstalk.

[1]  André Rodrigues,et al.  Mellitus , 2018, Proceedings of the 17th International Conference on Mobile and Ubiquitous Multimedia.

[2]  A. Tonnel,et al.  Endothelial cells , 1991 .

[3]  Ana I. Domingos,et al.  Sympathetic Neuro-adipose Connections Mediate Leptin-Driven Lipolysis , 2015, Cell.

[4]  P. Scherer,et al.  Selective enhancement of insulin sensitivity in the mature adipocyte is sufficient for systemic metabolic improvements , 2015, Nature Communications.

[5]  A. Hertig,et al.  Alteration of Fatty Acid Oxidation in Tubular Epithelial Cells: From Acute Kidney Injury to Renal Fibrogenesis , 2015, Front. Med..

[6]  J. McDonald,et al.  Targeted Induction of Ceramide Degradation Leads to Improved Systemic Metabolism and Reduced Hepatic Steatosis. , 2015, Cell metabolism.

[7]  G. Rutter,et al.  Limited impact on glucose homeostasis of leptin receptor deletion from insulin- or proglucagon-expressing cells , 2015, Molecular metabolism.

[8]  S. Yokoyama,et al.  Crystal structures of the human adiponectin receptors , 2015, Nature.

[9]  M. Roth,et al.  Glucagon receptor antibody completely suppresses type 1 diabetes phenotype without insulin by disrupting a novel diabetogenic pathway , 2015, Proceedings of the National Academy of Sciences.

[10]  Kumar Sharma,et al.  Defective fatty acid oxidation in renal tubular epithelial cells has a key role in kidney fibrosis development , 2014, Nature Medicine.

[11]  P. Scherer,et al.  Adiponectin is essential for lipid homeostasis and survival under insulin deficiency and promotes β-cell regeneration , 2014, eLife.

[12]  Alan Saghatelian,et al.  Discovery of a Class of Endogenous Mammalian Lipids with Anti-Diabetic and Anti-inflammatory Effects , 2014, Cell.

[13]  N. Curthoys,et al.  Proximal tubule function and response to acidosis. , 2014, Clinical journal of the American Society of Nephrology : CJASN.

[14]  Y. Lotan,et al.  Triglycerides in the Human Kidney Cortex: Relationship with Body Size , 2014, PloS one.

[15]  D. Kiortsis,et al.  The role of adiponectin in renal physiology and development of albuminuria. , 2014, The Journal of endocrinology.

[16]  I. Pernicova,et al.  Metformin—mode of action and clinical implications for diabetes and cancer , 2014, Nature Reviews Endocrinology.

[17]  Bingxuan Wang,et al.  Leptin- and Leptin Receptor-Deficient Rodent Models: Relevance for Human Type 2 Diabetes , 2014, Current diabetes reviews.

[18]  P. Scherer,et al.  Differential transendothelial transport of adiponectin complexes , 2014, Cardiovascular Diabetology.

[19]  J. Romijn,et al.  Sympathetic nervous system control of triglyceride metabolism: novel concepts derived from recent studies , 2014, Journal of Lipid Research.

[20]  K. Sharma,et al.  Adiponectin effects on the kidney. , 2014, Best practice & research. Clinical endocrinology & metabolism.

[21]  A. McAinch,et al.  Adipokines as a link between obesity and chronic kidney disease. , 2013, American journal of physiology. Renal physiology.

[22]  K. Matsuda,et al.  A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity , 2013, Nature.

[23]  Benjamin A. Neely,et al.  Blood-Based Indicators of Insulin Resistance and Metabolic Syndrome in Bottlenose Dolphins (Tursiops truncatus) , 2013, Front. Endocrinol..

[24]  Pei-Chun Chen,et al.  Leptin Regulates KATP Channel Trafficking in Pancreatic β-Cells by a Signaling Mechanism Involving AMP-activated Protein Kinase (AMPK) and cAMP-dependent Protein Kinase (PKA)* ♦ , 2013, The Journal of Biological Chemistry.

[25]  H. Münzberg,et al.  Integration of sensory information via central thermoregulatory leptin targets , 2013, Physiology & Behavior.

[26]  Vishal R. Patel,et al.  Leptin engages a hypothalamic neurocircuitry to permit survival in the absence of insulin. , 2013, Cell metabolism.

[27]  Lijun Li,et al.  Deletion of the insulin receptor in the proximal tubule promotes hyperglycemia. , 2013, Journal of the American Society of Nephrology : JASN.

[28]  J. Jeon,et al.  Leptin promotes KATP channel trafficking by AMPK signaling in pancreatic β-cells , 2013, Proceedings of the National Academy of Sciences.

[29]  P. Scherer,et al.  An FGF21-adiponectin-ceramide axis controls energy expenditure and insulin action in mice. , 2013, Cell metabolism.

[30]  Ying Wang,et al.  A role for hepatic leptin signaling in lipid metabolism via altered very low density lipoprotein composition and liver lipase activity in mice , 2013, Hepatology.

[31]  R. Gimeno,et al.  The breadth of FGF21's metabolic actions are governed by FGFR1 in adipose tissue. , 2013, Molecular metabolism.

[32]  D. McClain,et al.  MitoNEET-driven alterations in adipocyte mitochondrial activity reveal a crucial adaptive process that preserves insulin sensitivity in obesity , 2012, Nature Medicine.

[33]  T. Kusakabe,et al.  Leptin Activates Hepatic 5′-AMP-activated Protein Kinase through Sympathetic Nervous System and α1-Adrenergic Receptor , 2012, The Journal of Biological Chemistry.

[34]  C. Hoppel,et al.  Oxidation of Fatty Acids Is the Source of Increased Mitochondrial Reactive Oxygen Species Production in Kidney Cortical Tubules in Early Diabetes , 2012, Diabetes.

[35]  P. Scherer,et al.  Adiponectin: mechanistic insights and clinical implications , 2012, Diabetologia.

[36]  R. Cone,et al.  Melanocortin-3 receptor regulates the normal fasting response , 2012, Proceedings of the National Academy of Sciences.

[37]  J. Shapiro,et al.  Reactive Oxygen Species Modulation of Na/K-ATPase Regulates Fibrosis and Renal Proximal Tubular Sodium Handling , 2012, International journal of nephrology.

[38]  S. Hartwig,et al.  Adipokines: A treasure trove for the discovery of biomarkers for metabolic disorders , 2012, Proteomics. Clinical applications.

[39]  V. Paradis,et al.  Pathology of the liver in obese and diabetic ob/ob and db/db mice fed a standard or high‐calorie diet , 2011, International journal of experimental pathology.

[40]  S. Summers,et al.  Ceramides as modulators of cellular and whole-body metabolism. , 2011, The Journal of clinical investigation.

[41]  K. Sharma,et al.  AMPK mediates the initiation of kidney disease induced by a high-fat diet. , 2011, Journal of the American Society of Nephrology : JASN.

[42]  D. Lamers,et al.  Identification and Validation of Novel Adipokines Released from Primary Human Adipocytes* , 2011, Molecular & Cellular Proteomics.

[43]  D. S. Kim,et al.  Long‐Term Central Infusion of Adiponectin Improves Energy and Glucose Homeostasis by Decreasing Fat Storage and Suppressing Hepatic Gluconeogenesis without Changing Food Intake , 2011, Journal of neuroendocrinology.

[44]  Jonathan C. Cohen,et al.  Human Fatty Liver Disease: Old Questions and New Insights , 2011, Science.

[45]  K. Kaestner,et al.  Adiponectin suppresses gluconeogenic gene expression in mouse hepatocytes independent of LKB1-AMPK signaling. , 2011, The Journal of clinical investigation.

[46]  A. Kharitonenkov,et al.  FGF21 reloaded: challenges of a rapidly growing field , 2011, Trends in Endocrinology & Metabolism.

[47]  M. J. Charron,et al.  Glucagon Receptor Knockout Prevents Insulin-Deficient Type 1 Diabetes in Mice , 2011, Diabetes.

[48]  Karen Gallagher-Dorval,et al.  Body mass index-independent inflammation in omental adipose tissue associated with insulin resistance in morbid obesity. , 2011, Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery.

[49]  M. Birnbaum,et al.  Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin , 2011, Nature Medicine.

[50]  L. Marroqui,et al.  Leptin downregulates expression of the gene encoding glucagon in alphaTC1-9 cells and mouse islets , 2011, Diabetologia.

[51]  M. Fasshauer,et al.  Insulin-sensitive obesity. , 2010, American journal of physiology. Endocrinology and metabolism.

[52]  I. A. Bobulescu.  Renal lipid metabolism and lipotoxicity , 2010, Current opinion in nephrology and hypertension.

[53]  S. Harrison,et al.  Nonalcoholic fatty liver disease and hepatocellular carcinoma: A weighty connection , 2010, Hepatology.

[54]  G. Bedogni,et al.  Epidemiology of Non-Alcoholic Fatty Liver Disease , 2010, Digestive Diseases.

[55]  Y. Hayashi,et al.  Adiponectin and AdipoR1 regulate PGC-1α and mitochondria by Ca2+ and AMPK/SIRT1 , 2010, Nature.

[56]  J. Ix,et al.  Mechanisms linking obesity, chronic kidney disease, and fatty liver disease: the roles of fetuin-A, adiponectin, and AMPK. , 2010, Journal of the American Society of Nephrology : JASN.

[57]  O. Ilkayeva,et al.  Leptin therapy in insulin-deficient type I diabetes , 2010, Proceedings of the National Academy of Sciences.

[58]  G. Sweeney.  Cardiovascular effects of leptin , 2010, Nature Reviews Cardiology.

[59]  C. Mantzoros,et al.  Adiponectin in insulin resistance: lessons from translational research. , 2010, The American journal of clinical nutrition.

[60]  J. Tavaré,et al.  Saturated fatty acids induce insulin resistance in human podocytes: implications for diabetic nephropathy. , 2009, Nephrology, Dialysis and Transplantation.

[61]  O. Moe,et al.  Reduction of renal triglyceride accumulation: effects on proximal tubule Na+/H+ exchange and urinary acidification. , 2009, American journal of physiology. Renal physiology.

[62]  J. Pollard,et al.  Proangiogenic Contribution of Adiponectin toward Mammary Tumor Growth In vivo , 2009, Clinical Cancer Research.

[63]  R. Gomis,et al.  Inhibitory Effects of Leptin on Pancreatic α-Cell Function , 2009, Diabetes.

[64]  N. Bardeesy,et al.  Adiponectin suppresses hepatic SREBP1c expression in an AdipoR1/LKB1/AMPK dependent pathway. , 2009, Biochemical and biophysical research communications.

[65]  M. Koch,et al.  Leptin activates PI-3 kinase in C2C12 myotubes via janus kinase-2 (JAK-2) and insulin receptor substrate-2 (IRS-2) dependent pathways , 1997, Diabetologia.

[66]  D. Moller,et al.  Fibroblast growth factor 21 corrects obesity in mice. , 2008, Endocrinology.

[67]  Byung-Hyun Park,et al.  Making insulin-deficient type 1 diabetic rodents thrive without insulin , 2008, Proceedings of the National Academy of Sciences.

[68]  P. Scherer,et al.  The adipocyte as an endocrine cell. , 2008, Endocrinology and metabolism clinics of North America.

[69]  B. Falkner,et al.  Adiponectin regulates albuminuria and podocyte function in mice. , 2008, The Journal of clinical investigation.

[70]  B. Kemp,et al.  AMP-Activated Protein Kinase Regulates GLUT4 Transcription by Phosphorylating Histone Deacetylase 5 , 2008, Diabetes.

[71]  T. Kadowaki,et al.  Adiponectin induces insulin secretion in vitro and in vivo at a low glucose concentration , 2008, Diabetologia.

[72]  R. Cardiff,et al.  T-cadherin supports angiogenesis and adiponectin association with the vasculature in a mouse mammary tumor model. , 2008, Cancer research.

[73]  A. Chait,et al.  Leptin deficiency suppresses progression of atherosclerosis in apoE-deficient mice. , 2008, Atherosclerosis.

[74]  Krista Vandenborne,et al.  Transcriptional pathways associated with skeletal muscle disuse atrophy in humans. , 2007, Physiological genomics.

[75]  Hui Li,et al.  Disruption of leptin receptor expression in the pancreas directly affects beta cell growth and function in mice. , 2007, The Journal of clinical investigation.

[76]  G. Shulman,et al.  Obesity-associated improvements in metabolic profile through expansion of adipose tissue. , 2007, The Journal of clinical investigation.

[77]  Yihai Cao.  Angiogenesis modulates adipogenesis and obesity. , 2007, The Journal of clinical investigation.

[78]  L. Orci,et al.  Metabolic mechanisms of failure of intraportally transplanted pancreatic beta-cells in rats: role of lipotoxicity and prevention by leptin. , 2007, Diabetes.

[79]  J. Calbet,et al.  Leptin receptors in human skeletal muscle , 2007, Journal of applied physiology.

[80]  G. Schwartz,et al.  Mitochondria are the major targets in albumin-induced apoptosis in proximal tubule cells. , 2007, Journal of the American Society of Nephrology : JASN.

[81]  K. Hermansen,et al.  Fatty acid‐induced effect on glucagon secretion is mediated via fatty acid oxidation , 2007, Diabetes/metabolism research and reviews.

[82]  P. Froguel,et al.  Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions , 2007, Nature Medicine.

[83]  Scott D Covey,et al.  The pancreatic beta cell is a key site for mediating the effects of leptin on glucose homeostasis. , 2006, Cell metabolism.

[84]  M. J. Yoon,et al.  Adiponectin Increases Fatty Acid Oxidation in Skeletal Muscle Cells by Sequential Activation of AMP-Activated Protein Kinase, p38 Mitogen-Activated Protein Kinase, and Peroxisome Proliferator–Activated Receptor α , 2006, Diabetes.

[85]  E. Ravussin,et al.  Role of adiponectin in human skeletal muscle bioenergetics. , 2006, Cell metabolism.

[86]  P. Scherer.  Adipose Tissue , 2006, Diabetes.

[87]  G. Lopaschuk,et al.  Liver triglyceride secretion and lipid oxidative metabolism are rapidly altered by leptin in vivo. , 2006, Endocrinology.

[88]  R. Bonser,et al.  Human epicardial adipose tissue expresses a pathogenic profile of adipocytokines in patients with cardiovascular disease , 2006, Cardiovascular diabetology.

[89]  M. Schiffer,et al.  Glucose-induced reactive oxygen species cause apoptosis of podocytes and podocyte depletion at the onset of diabetic nephropathy. , 2006, Diabetes.

[90]  X. Niu,et al.  Inhibition of preproinsulin gene expression by leptin induction of suppressor of cytokine signaling 3 in pancreatic beta-cells. , 2005, Diabetes.

[91]  F. Dela,et al.  Effect of intermittent fasting and refeeding on insulin action in healthy men. , 2005, Journal of applied physiology.

[92]  S. Heymsfield,et al.  Low-dose leptin reverses skeletal muscle, autonomic, and neuroendocrine adaptations to maintenance of reduced weight. , 2005, The Journal of clinical investigation.

[93]  E. Chin,et al.  Role of Ca2+/calmodulin-dependent kinases in skeletal muscle plasticity. , 2005, Journal of applied physiology.

[94]  J. McManaman,et al.  Regulation of renal lipid metabolism, lipid accumulation, and glomerulosclerosis in FVBdb/db mice with type 2 diabetes. , 2005, Diabetes.

[95]  M. Focardi,et al.  Leptin receptors are expressed in coronary arteries, and hyperleptinemia causes significant coronary endothelial dysfunction. , 2005, American journal of physiology. Heart and circulatory physiology.

[96]  W. Garvey,et al.  Adiponectin promotes adipocyte differentiation, insulin sensitivity, and lipid accumulation Published, JLR Papers in Press, April 16, 2005. DOI 10.1194/jlr.M400373-JLR200 , 2005, Journal of Lipid Research.

[97]  P. Iyengar,et al.  Fat apoptosis through targeted activation of caspase 8: a new mouse model of inducible and reversible lipoatrophy , 2005, Nature Medicine.

[98]  J. Gromada,et al.  FGF-21 as a novel metabolic regulator. , 2005, The Journal of clinical investigation.

[99]  D. Kleiner,et al.  Leptin reverses nonalcoholic steatohepatitis in patients with severe lipodystrophy , 2005, Hepatology.

[100]  J. Friedman,et al.  Induction of Leptin Receptor Expression in the Liver by Leptin and Food Deprivation* , 2005, Journal of Biological Chemistry.

[101]  J. Friedman,et al.  Acute leptin deficiency, leptin resistance, and the physiologic response to leptin withdrawal. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[102]  R. R. Bowers,et al.  Brain–adipose tissue cross talk , 2005, The Proceedings of the Nutrition Society.

[103]  K. Nakao,et al.  The FASEB Journal express article 10.1096/fj.04-2183fje. Published online October 20, 2004. ©2004 FASEB , 2022 .

[104]  D. Romsos,et al.  Leptin Acts Peripherally to Limit Meal-Induced Increases in Plasma Insulin Concentrations in Mice: A Brief Communication , 2004, Experimental biology and medicine.

[105]  J. Schölmerich,et al.  Stimulatory short-term effects of free fatty acids on glucagon secretion at low to normal glucose concentrations. , 2004, Metabolism: clinical and experimental.

[106]  P. Rorsman,et al.  Palmitate stimulation of glucagon secretion in mouse pancreatic alpha-cells results from activation of L-type calcium channels and elevation of cytoplasmic calcium. , 2004, Diabetes.

[107]  P. Scherer,et al.  Fat-cell mass, serum leptin and adiponectin changes during weight gain and loss in yellow-bellied marmots (Marmota flaviventris) , 2004, Journal of Comparative Physiology B.

[108]  C. Diéguez,et al.  Dual action of adiponectin on insulin secretion in insulin-resistant mice. , 2004, Biochemical and biophysical research communications.

[109]  Guoxun Chen,et al.  Trace: Tennessee Research and Creative Exchange Nutrition Publications and Other Works Nutrition Central Role for Liver X Receptor in Insulin-mediated Activation of Srebp-1c Transcription and Stimulation of Fatty Acid Synthesis in Liver. Recommended Citation , 2022 .

[110]  M. Reitman,et al.  Genetic background (C57BL/6J versus FVB/N) strongly influences the severity of diabetes and insulin resistance in ob/ob mice. , 2004, Endocrinology.

[111]  R. Ahima,et al.  Adiponectin acts in the brain to decrease body weight , 2004, Nature Medicine.

[112]  NoriyukiOuchi,et al.  Selective Suppression of Endothelial Cell Apoptosis by the High Molecular Weight Form of Adiponectin , 2004 .

[113]  C. Fernández-Galaz,et al.  Leptin impairs insulin signaling in rat adipocytes. , 2004, Diabetes.

[114]  S. Kihara,et al.  Adiponectin Stimulates Angiogenesis by Promoting Cross-talk between AMP-activated Protein Kinase and Akt Signaling in Endothelial Cells* , 2004, Journal of Biological Chemistry.

[115]  C. García,et al.  Palmitate dependence of insulin secretion, “de novo” phospholipid synthesis and 45Ca2+-turnover in glucose stimulated rat islets , 1988, Diabetologia.

[116]  R. Somwar,et al.  Globular adiponectin increases GLUT4 translocation and glucose uptake but reduces glycogen synthesis in rat skeletal muscle cells , 2004, Diabetologia.

[117]  Y. Deshaies,et al.  A transgenic mouse with a deletion in the collagenous domain of adiponectin displays elevated circulating adiponectin and improved insulin sensitivity. , 2004, Endocrinology.

[118]  N. Tennagels,et al.  Adiponectin counteracts cytokine- and fatty acid-induced apoptosis in the pancreatic beta-cell line INS-1 , 2004, Diabetologia.

[119]  D. Eizirik,et al.  Expression of adiponectin receptors in pancreatic beta cells. , 2003, Biochemical and biophysical research communications.

[120]  O. Gavrilova,et al.  The clinical uses of leptin. , 2003, Current opinion in pharmacology.

[121]  S. Kihara,et al.  Enhanced carbon tetrachloride-induced liver fibrosis in mice lacking adiponectin. , 2003, Gastroenterology.

[122]  Yu Wang,et al.  The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice. , 2003, The Journal of clinical investigation.

[123]  Philippe Froguel,et al.  Cloning of adiponectin receptors that mediate antidiabetic metabolic effects , 2003, Nature.

[124]  H. Motoshima,et al.  Involvement of AMP-activated protein kinase in glucose uptake stimulated by the globular domain of adiponectin in primary rat adipocytes. , 2003, Diabetes.

[125]  Masataka Harada,et al.  Free fatty acids regulate insulin secretion from pancreatic β cells through GPR40 , 2003, Nature.

[126]  R. Curi,et al.  Leptin controls the fate of fatty acids in isolated rat white adipocytes. , 2002, The Journal of endocrinology.

[127]  H. Lodish,et al.  Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: Acetyl–CoA carboxylase inhibition and AMP-activated protein kinase activation , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[128]  S. Uchida,et al.  Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase , 2002, Nature Medicine.

[129]  C. Kahn,et al.  Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance. , 2002, Developmental cell.

[130]  T. Ortiga-Carvalho,et al.  The role of leptin in the regulation of TSH secretion in the fed state: in vivo and in vitro studies. , 2002, The Journal of endocrinology.

[131]  N. Cano,et al.  Bench-to-bedside review: Glucose production from the kidney , 2002, Critical care.

[132]  H. Shimano,et al.  Absence of Sterol Regulatory Element-binding Protein-1 (SREBP-1) Ameliorates Fatty Livers but Not Obesity or Insulin Resistance inLep ob /Lep ob Mice* , 2002, The Journal of Biological Chemistry.

[133]  S. Heymsfield,et al.  Low dose leptin administration reverses effects of sustained weight-reduction on energy expenditure and circulating concentrations of thyroid hormones. , 2002, The Journal of clinical endocrinology and metabolism.

[134]  S. Bloom,et al.  Acute stimulation of glucose uptake by leptin in l6 muscle cells. , 2002, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

[135]  C. Dina,et al.  Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population. , 2002, Diabetes.

[136]  Young-Bum Kim,et al.  Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase , 2002, Nature.

[137]  M. Stumvoll,et al.  Association of the T-G polymorphism in adiponectin (exon 2) with obesity and insulin sensitivity: interaction with family history of type 2 diabetes. , 2002, Diabetes.

[138]  L. Rossetti,et al.  Endogenous glucose production is inhibited by the adipose-derived protein Acrp30. , 2001, The Journal of clinical investigation.

[139]  S. Perrey,et al.  Severe Hypercholesterolemia, Hypertriglyceridemia, and Atherosclerosis in Mice Lacking Both Leptin and the Low Density Lipoprotein Receptor* , 2001, The Journal of Biological Chemistry.

[140]  Y. Terauchi,et al.  The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity , 2001, Nature Medicine.

[141]  P. Scherer,et al.  The adipocyte-secreted protein Acrp30 enhances hepatic insulin action , 2001, Nature Medicine.

[142]  H. Lodish,et al.  Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice. , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[143]  M. Stumvoll,et al.  Renal gluconeogenesis: its importance in human glucose homeostasis. , 2001, Diabetes care.

[144]  J. Flier,et al.  Transcriptional regulation of the thyrotropin-releasing hormone gene by leptin and melanocortin signaling. , 2001, The Journal of clinical investigation.

[145]  P. Rorsman,et al.  Regulation of glucagon release in mouse α‐cells by KATP channels and inactivation of TTX‐sensitive Na+ channels , 2000, The Journal of physiology.

[146]  L. Eliasson,et al.  Tight coupling between electrical activity and exocytosis in mouse glucagon-secreting alpha-cells. , 2000, Diabetes.

[147]  F. Casanueva,et al.  Regulation of in vivo TSH secretion by leptin , 2000, Regulatory Peptides.

[148]  M. Konishi,et al.  Identification of a novel FGF, FGF-21, preferentially expressed in the liver. , 2000, Biochimica et biophysica acta.

[149]  T Nakamura,et al.  Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients. , 2000, Arteriosclerosis, thrombosis, and vascular biology.

[150]  L. Leon,et al.  Torpor in mice is induced by both leptin-dependent and -independent mechanisms. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[151]  R. Hammer,et al.  Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy , 1999, Nature.

[152]  K. Hosoda,et al.  Sympathetic activation of leptin via the ventromedial hypothalamus: leptin-induced increase in catecholamine secretion. , 1999, Diabetes.

[153]  N. Chinookoswong,et al.  Leptin restores euglycemia and normalizes glucose turnover in insulin-deficient diabetes in the rat. , 1999, Diabetes.

[154]  C. Ricordi,et al.  Journal of Clinical Endocrinology and Metabolism Printed in U.S.A. Copyright © 1999 by The Endocrine Society Leptin Suppression of Insulin Secretion and Gene Expression in Human Pancreatic Islets: Implications for the Development of Adipogenic Diabetes Me , 2022 .

[155]  J. Halaas,et al.  Leptin and the regulation of body weight in mammals , 1998, Nature.

[156]  M. Olive,et al.  Life without white fat: a transgenic mouse. , 1998, Genes & development.

[157]  M. Matheny,et al.  Leptin induction of UCP1 gene expression is dependent on sympathetic innervation. , 1998, American journal of physiology. Endocrinology and metabolism.

[158]  I. Schmidt,et al.  Leptin selectively increases energy expenditure of food-restricted lean mice , 1998, International Journal of Obesity.

[159]  R. Bretzel,et al.  Leptin inhibition of insulin secretion from isolated human islets , 1997, Acta Diabetologica.

[160]  V. Barr,et al.  Insulin stimulates both leptin secretion and production by rat white adipose tissue. , 1997, Endocrinology.

[161]  C Meyer,et al.  Human kidney free fatty acid and glucose uptake: evidence for a renal glucose-fatty acid cycle. , 1997, The American journal of physiology.

[162]  J. Friedman,et al.  Physiological response to long-term peripheral and central leptin infusion in lean and obese mice. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[163]  R. Coleman,et al.  Leptin Directly Alters Lipid Partitioning in Skeletal Muscle , 1997, Diabetes.

[164]  V. Emilsson,et al.  Leptin inhibits glycogen synthesis in the isolated soleus muscle of obese (ob/ob) mice , 1997, FEBS letters.

[165]  J. Habener,et al.  Leptin Suppression of Insulin Secretion by the Activation of ATP-Sensitive K+ Channels in Pancreatic β-Cells , 1997, Diabetes.

[166]  G. Müller,et al.  Leptin Impairs Metabolic Actions of Insulin in Isolated Rat Adipocytes* , 1997, The Journal of Biological Chemistry.

[167]  V. Emilsson,et al.  Expression of the Functional Leptin Receptor mRNA in Pancreatic Islets and Direct Inhibitory Action of Leptin on Insulin Secretion , 1997, Diabetes.

[168]  M. Mozzoli,et al.  Effect of fasting on serum leptin in normal human subjects. , 1996, The Journal of clinical endocrinology and metabolism.

[169]  C. Mantzoros,et al.  Role of leptin in the neuroendocrine response to fasting , 1996, Nature.

[170]  A. Gurney,et al.  Decreased food intake does not completely account for adiposity reduction after ob protein infusion. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[171]  Philipp E. Scherer,et al.  A Novel Serum Protein Similar to C1q, Produced Exclusively in Adipocytes (*) , 1995, The Journal of Biological Chemistry.

[172]  M. Pelleymounter,et al.  Effects of the obese gene product on body weight regulation in ob/ob mice. , 1995, Science.

[173]  Steven L. Cohen,et al.  Weight-reducing effects of the plasma protein encoded by the obese gene. , 1995, Science.

[174]  M. Maffei,et al.  Positional cloning of the mouse obese gene and its human homologue , 1995, Nature.

[175]  M. Maffei,et al.  Positional cloning of the mouse obese gene and its human homologue , 1994, Nature.

[176]  B. Paigen,et al.  Characterization of plasma lipids in genetically obese mice: the mutants obese, diabetes, fat, tubby, and lethal yellow. , 1994, Metabolism: clinical and experimental.

[177]  P. Gilon,et al.  Mechanisms of the Stimulation of Insulin Release by Saturated Fatty Acids: A Study of Palmitate Effects in Mouse β-cells , 1994, Diabetes.

[178]  V. Hubbard,et al.  Characterization of the insulinotropic potency of polyunsaturated fatty acids. , 1992, Endocrinology.

[179]  G. Bray.  Obesity, a disorder of nutrient partitioning: the MONA LISA hypothesis. , 1991, The Journal of nutrition.

[180]  G. Dimitriadis,et al.  Abnormal Glucose Modulation of Islet A- and B-Cell Responses to Arginine in Non-insulin-dependent Diabetes Mellitus , 1985, Diabetes.

[181]  Z. Varghese,et al.  LIPID NEPHROTOXICITY IN CHRONIC PROGRESSIVE GLOMERULAR AND TUBULO-INTERSTITIAL DISEASE , 1982, The Lancet.

[182]  M. Walsh,et al.  Glucagon and Insulin Secretion by Islets of Lean and Obese (ob/ob) Mice , 1980, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

[183]  C. A. Benzo,et al.  Glucagon and Insulin Relationships in Genetically Diabetic (db/db) and in Streptozotocin-Induced Diabetic Mice* , 1978, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

[184]  W. James,et al.  Thermogenic defect in pre-obese ob/ob mice , 1977, Nature.

[185]  W. A. Müller,et al.  Abnormal alpha-cell function in diabetes. Response to carbohydrate and protein ingestion. , 1970, The New England journal of medicine.

[186]  W. Malaisse,et al.  Stimulation of insulin secretion by noncarbohydrate metabolites. , 1968, The Journal of laboratory and clinical medicine.

[187]  Baig Ar,et al.  Sex-chromatin values in rat epithelium. , 1967 .

[188]  H. Harris,et al.  The Rat , 1958, Nature.

[189]  J. Mayer.  REGULATION OF ENERGY INTAKE AND THE BODY WEIGHT: THE GLUCOSTATIC THEORY AND THE LIPOSTATIC HYPOTHESIS , 1955, Annals of the New York Academy of Sciences.

[190]  G. C. Kennedy,et al.  The role of depot fat in the hypothalamic control of food intake in the rat , 1953, Proceedings of the Royal Society of London. Series B - Biological Sciences.

[191]  M. Kleiber.  Body size and metabolism , 1932 .