Epstein‐Barr virus encephalomyelitis diagnosed by polymerase chain reaction

A case of encephalomyelitis with polymerase chain reaction detection of Epstein-Barr virus (EBV) in the CSF, and concurrent serologic changes consistent with acute systemic EBV infection is presented and discussed. We document involvement of the brain, spinal cord, and nerve roots, summarize some unusual imaging findings, and note the evolution of CSF oligoclonal bands.

[1]  J. Morgenlander A syndrome of concurrent central and peripheral nervous system involvement due to Epstein‐Barr virus infection , 1996, Muscle & nerve.

[2]  E. Kieff Epstein-Barr virus and its replication , 1996 .

[3]  M. Kaji,et al.  Detection of Epstein-Barr virus genome in peripheral leucocytes and CSF by the polymerase chain reaction in two patients with Epstein-Barr virus related to aseptic meningitis. , 1995, Journal of neurology, neurosurgery, and psychiatry.

[4]  K. Tyler Polymerase chain reaction and the diagnosis of viral central nervous system diseases , 1994, Annals of neurology.

[5]  M. Landgren,et al.  Diagnosis of Epstein‐Barr virus–induced central nervous system infections by DNA amplification from cerebrospinal fluid , 1994, Annals of neurology.

[6]  M. Cotton,et al.  Acute aqueductal stenosis in a patient with Epstein-Barr virus infectious mononucleosis. , 1994, The Pediatric infectious disease journal.

[7]  E. Lahat,et al.  Alice in Wonderland syndrome, a manifestation of acute Epstein-Barr virus infection. , 1987, The Pediatric infectious disease journal.

[8]  K. Mohanaruban,et al.  A combination of cranial and peripheral nerve palsies in infectious mononucleosis. , 1986, Postgraduate medical journal.

[9]  J. Robinson,et al.  Epstein-Barr virus in cerebrospinal fluid during infectious mononucleosis encephalitis. , 1982, The Yale Journal of Biology and Medicine.

[10]  J. Burks,et al.  An unusual case of encephalomyeloradiculoneuropathy in a young woman. , 1981, Archives of neurology.

[11]  C. Halsted,et al.  Infectious mononucleosis and encephalitis: recovery of EB virus from spinal fluid. , 1979, Pediatrics.

[12]  M. Bertrand,et al.  Epstein-Barr virus antibodies in the cerebrospinal fluid. A case of infectious mononucleosis with encephalitis. , 1974, American journal of diseases of children.

[13]  W. Henle,et al.  Epstein-Barr virus specific diagnostic tests in infectious mononucleosis. , 1974, Human pathology.

[14]  A. Silverstein,et al.  Nervous system involvement in infectious mononucleosis. The heralding and-or major manifestation. , 1972, Archives of neurology.