Psoriasis Onset with Tocilizumab Treatment for Rheumatoid Arthritis

To the Editor: Tocilizumab (TCZ) is a humanized monoclonal antibody directed against the interleukin 6 (IL-6) receptor, approved in the treatment of rheumatoid arthritis (RA), with potential use in other inflammatory diseases1. We describe a case of psoriasis onset during TCZ treatment in a patient with RA. A white woman, born in 1955, for 20 years had erosive RA, negative for anticitrullinated protein antibodies. Her condition did not respond to several disease-modifying … Address correspondence to Prof. D. Wendling, University Hospital J. Minjoz – Rheumatology, Boulevard Fleming, Besancon 25030, France. E-mail: dwendling{at}chu-besancon.fr

[1]  A. Ogata,et al.  Psoriatic arthritis in two patients with an inadequate response to treatment with tocilizumab. , 2012, Joint, bone, spine : revue du rhumatisme.

[2]  C. Roux,et al.  Reactivation of cutaneous psoriasis during abatacept therapy for spondyloarthropathy. , 2010, Joint, bone, spine : revue du rhumatisme.

[3]  M. Breban,et al.  Onset of psoriasis following treatment with tocilizumab , 2010, The British journal of dermatology.

[4]  C. Gabay,et al.  Tocilizumab in a patient with ankylosing spondylitis and Crohn's disease refractory to TNF antagonists. , 2010, Joint, bone, spine : revue du rhumatisme.

[5]  X. Mariette,et al.  Tocilizumab: therapy and safety management. , 2010, Joint, bone, spine : revue du rhumatisme.

[6]  P. Voulgari,et al.  Induction of psoriatic skin lesions in a patient with rheumatoid arthritis treated with rituximab. , 2009, Clinical and experimental rheumatology.

[7]  F. Aubin,et al.  Onset or exacerbation of cutaneous psoriasis during TNFalpha antagonist therapy. , 2008, Joint, bone, spine : revue du rhumatisme.

[8]  A. Zalewska,et al.  Interleukin 6 and 8 Levels in Plasma and Fibroblast Cultures in Psoriasis , 2006, Mediators of inflammation.

[9]  D. P. Murphy,et al.  Interleukin 6 is expressed in high levels in psoriatic skin and stimulates proliferation of cultured human keratinocytes. , 1989, Proceedings of the National Academy of Sciences of the United States of America.