Infection with GB virus C (GBV‐C) in patients with chronic liver disease or on maintenance hemodialysis in Indonesia

RNA of a non‐A to E hepatitis virus identified recently and designated provisionally GB virus C (GBV‐C), was sought in patients in Indonesia by reverse‐transcription polymerase chain reaction with nested primers deduced from a helicase‐like region. GBV‐C RNA was detected in 32 (55%) of 58 patients on maintenance hemodialysis at a frequency significantly higher (P < 0.001) than that in seven (5%) of 149 patients with chronic liver disease. Co‐infection with hepatitis C virus was observed in 26 (81%) of the 32 patients on hemodialysis and in five (71%) of the seven patients with liver disease who were infected with GBV‐C. Complete identity was observed in a sequence of 100 base pairs in the helicase‐like region for GBV‐C cDNA clones from some patients on maintenance hemodialysis. These results indicate that the patients on hemodialysis would be at high risk for GBV‐C infection, which would be transmitted by transfusion and patient‐to‐patient routes. © 1996 Wiley‐Liss, Inc.

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