Application of Biocatalytic Reductive Amination for the Synthesis of a Key Intermediate to a CDK 2/4/6 Inhibitor

[1]  Nga M. Do,et al.  Biocatalytic reductive amination from discovery to commercial manufacturing applied to abrocitinib JAK1 inhibitor , 2021, Nature Catalysis.

[2]  J. Lapek,et al.  Discovery of PF-06873600, a CDK2/4/6 Inhibitor for the Treatment of Cancer. , 2021, Journal of medicinal chemistry.

[3]  Teresa W. Makowski,et al.  A radical chlorodifluoromethylation protocol for late-stage difluoromethylation and its application to an oncology candidate , 2021 .

[4]  B. O’Neill,et al.  Ketoreductase/Transaminase, One-Pot, Multikilogram Biocatalytic Cascade Reaction , 2021 .

[5]  Jason Mustakis,et al.  Developing a Multistep Continuous Manufacturing Process for (1R,2R)-2-Amino-1-methylcyclopentan-1-ol , 2020 .

[6]  U. Bornscheuer,et al.  Biocatalysis: Enzymatic Synthesis for Industrial Applications , 2020, Angewandte Chemie.

[7]  A. Bommarius,et al.  Recent Advances in ω-Transaminase-Mediated Biocatalysis for the Enantioselective Synthesis of Chiral Amines , 2018, Catalysts.

[8]  John M. Woodley,et al.  Role of Biocatalysis in Sustainable Chemistry. , 2017, Chemical reviews.

[9]  N. Turner,et al.  NAD(P)H‐Dependent Dehydrogenases for the Asymmetric Reductive Amination of Ketones: Structure, Mechanism, Evolution and Application , 2017, Advanced synthesis & catalysis.

[10]  Nicholas J Turner,et al.  Imine reductases (IREDs). , 2017, Current opinion in chemical biology.

[11]  M. Dowsett,et al.  Early Adaptation and Acquired Resistance to CDK4/6 Inhibition in Estrogen Receptor-Positive Breast Cancer. , 2016, Cancer research.

[12]  S. Buchwald,et al.  Regioselective 2-Amination of Polychloropyrimidines. , 2016, Organic letters.

[13]  Wolfgang Kroutil,et al.  Biocatalytic Imine Reduction and Reductive Amination of Ketones , 2015 .

[14]  Jan Streuff,et al.  Titanium-catalyzed reductive umpolung reactions with a metal-free terminal reducing agent. , 2015, Chemistry.

[15]  H. Kohls,et al.  Recent achievements in developing the biocatalytic toolbox for chiral amine synthesis. , 2014, Current opinion in chemical biology.

[16]  F. G. Mutti,et al.  Asymmetric Preparation of prim-, sec-, and tert-Amines Employing Selected Biocatalysts , 2013, Organic process research & development.

[17]  Jan Streuff,et al.  Enantioselective titanium(III)-catalyzed reductive cyclization of ketonitriles. , 2012, Angewandte Chemie.

[18]  T. Nugent Chiral amine synthesis : methods, developments and applications , 2010 .

[19]  Toyokazu Yoshida,et al.  Imine Reductases for Chiral Amine Synthesis , 2017 .

[20]  D. Vasić-Rački,et al.  Cofactor regeneration at the lab scale. , 2005, Advances in biochemical engineering/biotechnology.