The mixed‐lineage kinase 1–3 signalling pathway regulates stress response in cardiac myocytes via GATA‐4 and AP‐1 transcription factors

Background and purpose:  The mixed‐lineage kinases (MLKs) act upstream of mitogen‐activated protein kinases, but their role in cardiac biology and pathology is largely unknown.

[1]  J. Molkentin,et al.  The Transcription Factor GATA4 Is Activated by Extracellular Signal-Regulated Kinase 1- and 2-Mediated Phosphorylation of Serine 105 in Cardiomyocytes , 2001, Molecular and Cellular Biology.

[2]  Eugene M. Johnson,et al.  Mixed-lineage kinases: a target for the prevention of neurodegeneration. , 2004, Annual review of pharmacology and toxicology.

[3]  S. Katz,et al.  Expression of mitogen‐activated protein kinase pathways during postnatal development of rat heart , 1998, Journal of cellular biochemistry.

[4]  S. Pikkarainen,et al.  Mechanical load-induced alterations in B-type natriuretic peptide gene expression. , 2001, Canadian journal of physiology and pharmacology.

[5]  A. Clerk,et al.  Cellular mechanisms of cardiac hypertrophy , 1998, Journal of Molecular Medicine.

[6]  R. Treisman,et al.  The p38 and ERK MAP kinase pathways cooperate to activate Ternary Complex Factors and c‐fos transcription in response to UV light. , 1996, The EMBO journal.

[7]  M. Karin,et al.  The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation. , 1991, Biochimica et biophysica acta.

[8]  R. Burke,et al.  CEP11004, a novel inhibitor of the mixed lineage kinases, suppresses apoptotic death in dopamine neurons of the substantia nigra induced by 6‐hydroxydopamine , 2003, Journal of neurochemistry.

[9]  A. Sharrocks,et al.  Integration of MAP kinase signal transduction pathways at the serum response element. , 1995, Science.

[10]  Yu‐hui Yang,et al.  Amphetamine activates connexin43 gene expression in cultured neonatal rat cardiomyocytes through JNK and AP-1 pathway. , 2004, Cardiovascular research.

[11]  F. Charron,et al.  GATA-4 Is a Nuclear Mediator of Mechanical Stretch-activated Hypertrophic Program* , 2003, Journal of Biological Chemistry.

[12]  E. Wagner,et al.  AP-1: a double-edged sword in tumorigenesis , 2003, Nature Reviews Cancer.

[13]  Shokei Kim,et al.  Dominant Negative Mutant of c-Jun Inhibits Cardiomyocyte Hypertrophy Induced by Endothelin 1 and Phenylephrine , 2002, Hypertension.

[14]  S. Pikkarainen,et al.  Endothelin-1-specific Activation of B-type Natriuretic Peptide Gene via p38 Mitogen-activated Protein Kinase and Nuclear ETS Factors* , 2003, The Journal of Biological Chemistry.

[15]  H. Ruskoaho.  Atrial natriuretic peptide: synthesis, release, and metabolism. , 1992, Pharmacological reviews.

[16]  S. Sasayama,et al.  Phosphorylation of GATA-4 Is Involved in α1-Adrenergic Agonist-responsive Transcription of the Endothelin-1 Gene in Cardiac Myocytes* , 2000, The Journal of Biological Chemistry.

[17]  Dazhong Xu,et al.  Mixed-lineage kinase 3 regulates B-Raf through maintenance of the B-Raf/Raf-1 complex and inhibition by the NF2 tumor suppressor protein. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[18]  D. Thuerauf,et al.  Differential Effects of Protein Kinase C, Ras, and Raf-1 Kinase on the Induction of the Cardiac B-type Natriuretic Peptide Gene through a Critical Promoter-proximal M-CAT Element* , 1997, The Journal of Biological Chemistry.

[19]  J A Peters,et al.  Guide to Receptors and Channels (GRAC), 3rd edition , 2008, British journal of pharmacology.

[20]  J. Avruch,et al.  Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. , 2001, Physiological reviews.

[21]  A. Lin,et al.  Dynamic Positive Feedback Phosphorylation of Mixed Lineage Kinase 3 by JNK Reversibly Regulates Its Distribution to Triton-soluble Domains* , 2006, Journal of Biological Chemistry.

[22]  P. Sugden.  Ras, Akt, and Mechanotransduction in the Cardiac Myocyte , 2003, Circulation research.

[23]  M. Yacoub,et al.  Hypertrophic agonists induce the binding of c-Fos to an AP-1 site in cardiac myocytes: implications for the expression of GLUT1. , 2003, Cardiovascular research.

[24]  Irene C. Blat,et al.  MLK3 limits activated Galphaq signaling to Rho by binding to p63RhoGEF. , 2008, Molecular cell.

[25]  R. Beavis,et al.  Tissue distribution and functional expression of a cDNA encoding a novel mixed lineage kinase. , 2001, Journal of molecular and cellular cardiology.

[26]  G. Johnson,et al.  Signalling: Mixed-lineage kinase control of JNK and p38 MAPK pathways , 2002, Nature Reviews Molecular Cell Biology.

[27]  P. Sugden.  An overview of endothelin signaling in the cardiac myocyte. , 2003, Journal of molecular and cellular cardiology.

[28]  John C. Lee,et al.  Extracellular Signal-regulated Kinase Plays an Essential Role in Hypertrophic Agonists, Endothelin-1 and Phenylephrine-induced Cardiomyocyte Hypertrophy* , 2000, The Journal of Biological Chemistry.

[29]  D. Barford,et al.  Mechanism of Activation of the RAF-ERK Signaling Pathway by Oncogenic Mutations of B-RAF , 2004, Cell.

[30]  J. Kyriakis,et al.  MLK3 is required for mitogen activation of B-Raf, ERK and cell proliferation , 2004, Nature Cell Biology.

[31]  P. Iversen,et al.  Transgenic mice with cardiac-specific over-expression of MLK7 have increased mortality when exposed to chronic beta-adrenergic stimulation. , 2004, Journal of molecular and cellular cardiology.

[32]  R. Flavell,et al.  Role of MLK3 in the Regulation of Mitogen-Activated Protein Kinase Signaling Cascades , 2005, Molecular and Cellular Biology.

[33]  D. Bozyczko‐Coyne,et al.  CEP-11004, an inhibitor of the SAPK/JNK pathway, reduces TNF-alpha release from lipopolysaccharide-treated cells and mice. , 2005, European journal of pharmacology.

[34]  Jeffrey Robbins,et al.  A Calcineurin-Dependent Transcriptional Pathway for Cardiac Hypertrophy , 1998, Cell.

[35]  J. Molkentin,et al.  Regulation of cardiac hypertrophy by intracellular signalling pathways , 2006, Nature Reviews Molecular Cell Biology.

[36]  D. Bozyczko‐Coyne,et al.  Mixed lineage kinase activity of indolocarbazole analogues. , 2002, Bioorganic & medicinal chemistry letters.

[37]  J. Woodgett,et al.  Glycogen Synthase Kinase-3β Induces Neuronal Cell Death via Direct Phosphorylation of Mixed Lineage Kinase 3* , 2007, Journal of Biological Chemistry.

[38]  W. Pu,et al.  Morphogenesis of the right ventricle requires myocardial expression of Gata4. , 2005, The Journal of clinical investigation.

[39]  J. Kyriakis,et al.  A Novel Role for Mixed Lineage Kinase 3 (MLK3) in B-Raf Activation and Cell proliferation , 2004, Cell cycle.

[40]  R. Lefkowitz,et al.  Targeting the receptor-Gq interface to inhibit in vivo pressure overload myocardial hypertrophy. , 1998, Science.

[41]  H. Ruskoaho,et al.  Mitogen-activated Protein Kinases p38 and ERK 1/2 Mediate the Wall Stress-induced Activation of GATA-4 Binding in Adult Heart* , 2004, Journal of Biological Chemistry.

[42]  S. Pikkarainen,et al.  Distinct Roles of Mitogen-activated Protein Kinase Pathways in GATA-4 Transcription Factor-mediated Regulation of B-type Natriuretic Peptide Gene* , 2002, The Journal of Biological Chemistry.