Antitumor Effect of Natural Product Molecules against Lung Cancer

Lung cancer treatment remains difficult because of multidrug resistance and adverse effects, and natural product molecules show powerful activity in lung cancer with few side effects. The molecular targets and efficacy of natural product molecules remain unclear. We described the molecular regulation of natural product molecules with antitumor activities, the antilung cancer activities and the clinical trials for lung cancer treatment of natural product molecules. The results support the updated systemic infor mation on the use of natural product molecules to prevent cancer progression and their constituents for lung cancer treatment. mouse model. When used theaflavins in 0.02 mg/mouse/day and EGCG dose of 0.01 mg/mouse/ day, results show that both of them reduced the obvious carcinoma and dysplasia in situ at 8th, 17th, and 26th weeks. In Swiss albino rats, GTP treatment and black tea polyphenols (BTP) at dosage of 0.1 and 0.2% resulted in low incidence of diethylnitrosamine-induced alveologenic tumors, which resulted in the inhibition of the expression of lung cancer caused by Akt, cyclooxygenase (COX)-2, and nuclear factor kappa-B (NF-κB) The combination of liquid Polyphenon E (0.25 or 0.25%) and atorvastatin-inhibited lung cancer induced by (NNK) in mice. Low-dose combination of Polyphenon E and atorvastatin significantly reduced the lung tumor diversity and enhanced cell apoptosis but inhibited tumor burden at myelogenous leukemia 1 (Mcl-1) level. Results show that lung tumors were effectively inhibited by atorvastatin and Polyphenon E, and in vitro and in vivo , the action between the two agents was synergistic. The inhibition activity of atomized difluoromethylornithine (DFMO) and Polyphenon E (1% wt/wt diet) admin istration was investigated in A/J mice injected with B(a)P. Polyphenon E did not suppress tumor treatment on average diversity but decreased the animal tumor load and significantly reduced the largest carcinoma