IMMUNITY LEVEL TO HEPATITIS B VIRUS IN VACCINATED MEDICAL STUDENTS

Hepatitis B is a wide world disease and more than 1/3 of people in the world are HBs Ag positive. HBV causes chronic hepatitis, acute hepatitis, chronic cirrhosis and hepatocellular carcinoma in adults and children. This research was done for evaluation of immunogenicity of HBV vaccine with HBs Ab measurement after vaccination. This descriptive cross-sectional study was done on 135 medical students of Jahrom University of medical science who had been vaccinated three times. The obtained serum was tested by Elisa method to determine for Anti-HBs antibodies. All collected data were entered in statistical software program SPSS (version 16) and were analyzed by descriptive statistics and chi-square and t-test. Out of 135 medical students, 102(75.6%) were women. In this study 13(9.6%) subjects had anti-HBs titer of 10-100(mIu mL-1) and 122(90.4%) subjects had anti-HBs titer of >100 mIu mL-1. There was no correlation between immunity level and age, sex, BMI, time after last vaccination and past record of needle stick at work place. Although immunity to hepatitis B was in protective level among all participants, assessment of immunity in healthcare workers after complete vaccination recommended.

[1]  Mohammad Rahimi-Madiseh,et al.  Immunization following hepatitis B mass vaccination in the 18 years old students in Chaharmahal va Bakhtyari province in Iran , 2011 .

[2]  Sanaullah Khan,et al.  Prevalence of HBV and HBV vaccination coverage in health care workers of tertiary hospitals of Peshawar, Pakistan , 2011, Virology Journal.

[3]  S. Yusnita,et al.  An estimation of the occupational risk of HBV, HCV and HIV infection among Indonesian health-care workers. , 2009, Acta medica Indonesiana.

[4]  H. Ghadimi,et al.  Long term effects of one or two doses of hepatitis B vaccine in adults after five years. , 2008, Pakistan journal of biological sciences : PJBS.

[5]  Matthew E. Falagas,et al.  Factors associated with , 2008 .

[6]  M. A. Zargar,et al.  PREVALENCE OF HEPATITIS B ANTIBODIES IN HEALTH-CARE WORKERS IN YASUJ HOSPITALS , 2007 .

[7]  Joukar Farahnaz,et al.  The Immunologic Response to Anti-Hepatitis B Vaccination Among Medical Students of Guilan University of Medical Sciences, Guilan, Iran , 2006 .

[8]  M. Askarian,et al.  The prevalence of needle stick injuries in medical, dental, nursing and midwifery students at the university teaching hospitals of Shiraz, Iran. , 2006, Indian journal of medical sciences.

[9]  Rifat-uz-Zaman,et al.  Prevalence of Hepatitis B and Hepatitis C Viruses in Human Urban Population of Bahawalpur District, Pakistan , 2006 .

[10]  J. Hou,et al.  Epidemiology and Prevention of Hepatitis B Virus Infection , 2005, International journal of medical sciences.

[11]  S. Umar,et al.  Studies on the Prevalence of Hepatitis B Virus in Relation to Sex, Age, Promotive Factors, Associated Symptoms and Season Among Human Urban , 2004 .

[12]  A. Floreani,et al.  Long-term persistence of anti-HBs after vaccination against HBV: an 18 year experience in health care workers. , 2004, Vaccine.

[13]  S. Teles,et al.  Immunogenicity of a recombinant hepatitis B vaccine (Euvax-B) in haemodialysis patients and staff , 2004, European Journal of Epidemiology.

[14]  M. Alter,et al.  Hepatitis B virus (HBV) and hepatitis C virus (HCV) infections in health care workers (HCWs): guidelines for prevention of transmission of HBV and HCV from HCW to patients. , 2003, Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology.

[15]  F. Keshavarz,et al.  THE IMMUNOGENIC OF HEPATITS B VACCINE IN PERSONNEL OF SINA HOSPITAL OF HAMEDAN (IRAN, 2001) , 2002 .

[16]  H. Margolis,et al.  Childhood hepatitis B virus infections in the United States before hepatitis B immunization. , 2001, Pediatrics.

[17]  K. Nasir,et al.  Hepatitis B vaccination among health care workers and students of a medical college. , 2000, JPMA. The Journal of the Pakistan Medical Association.

[18]  J. Burillo,et al.  Factores asociados a una respuesta inadecuada a la vacunación contra la hepatitis B en personal sanitario , 1998 .

[19]  K. Sepkowitz,et al.  Hepatitis B vaccination program at a New York City hospital: seroprevalence, seroconversion, and declination. , 1998, American journal of infection control.

[20]  K. Rosenman,et al.  Age-related hepatitis B seroconversion rates in health care workers. , 1997, American journal of infection control.

[21]  E. Scolnick,et al.  Overview of clinical studies with hepatitis B vaccine made by recombinant DNA. , 1986, The Journal of infection.

[22]  W Z BILLEWICZ,et al.  Indices of Adiposity , 1962, British journal of preventive & social medicine.