MicroRNA‐575 targets BLID to promote growth and invasion of non‐small cell lung cancer cells

This study was designed to detect miR‐575 expression and function in non‐small cell lung cancer (NSCLC). A higher expression of miR‐575 in NSCLC tissues was observed compared with adjacent non‐neoplastic tissues. Furthermore, re‐introduction of miR‐575 significantly promoted cell proliferation, migration, and invasion in the NSCLC line. Moreover, we showed that BLID is negatively regulated by miR‐575 at the posttranscriptional level, via a specific target site within the 3′UTR. Overexpression of BLID counteracted miR‐575‐induced proliferation and invasion in NSCLC cells. The expression of BLID is frequently downregulated in NSCLC tumors and cell lines and inversely correlates with miR‐575 expression. The findings of this study contribute to the current understanding of the functions of miR‐575 in NSCLC.

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